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Recombinant human and fish STC2 proteins were generated and found to be N-glycosylated homodimers. STC2 is a functional homodimeric glycoprotein, and thecal cell-derived STC2 could play a paracrine role during follicular development. (Stanniocalcin-2)
Our results demonstrated the contrasting effects of STC1 (zeige STC1 Proteine) and STC2-derived peptides on human macrophage foam cell formation associated with ACAT1 (zeige ACAT1 Proteine) expression and on HASMC migration.
Mus81 (zeige MUS81 Proteine) knockdown suppresses proliferation and survival of HCC (zeige FAM126A Proteine) cells likely by downregulating STC2 expression, implicating Mus81 (zeige MUS81 Proteine) as a therapeutic target for HCC (zeige FAM126A Proteine).
These findings indicated that STC2 may promote osteoblast differentiation and mineralization by regulating ERK (zeige EPHB2 Proteine) activation
STC2 is involved in regulating PAPP-A (zeige PAPPA Proteine) activity during the development of atherosclerosis
Data suggest that stanniocalcin 1 (zeige STC1 Proteine) and 2 (STC1 (zeige STC1 Proteine), STC2) participate in inhibition of proteolytic activity of pregnancy-associated plasma protein-A (PAPP-A (zeige PAPPA Proteine)) during folliculogenesis.
Up-regulation of CDK2 and CDK4 and down-regulation of cell cycle inhibitors p16 and p21 were observed after the delivery of STC2. Furthermore, STC2 transduction activated pAKT and pERK 1/2 signal pathways.
The results showed that the expression of HMGA2 and STC2 was positively correlated. Furthermore, STC2 expression was significantly associated with tumor grade and histotype.
This study utilized ER+ IBC to identify a metagene including ABAT (zeige ABAT Proteine) and STC2 as predictive biomarkers for endocrine therapy resistance.
STC2 may inhibit epithelial-mesenchymal transition at least partially through the PKC (zeige PRRT2 Proteine)/Claudin-1 (zeige CLDN7 Proteine)-mediated signaling in human breast cancer cells.
STC2 has a role in promoting cell proliferation and cisplatin resistance in cervical cancer
results in MTA2 recruitment to the Stc2 promoter, concomitant with agonist-specific epigenetic modifications targeting histone H4 lysine acetylation
Stanniocalcin-2 inhibits proteolytic release of IGF and its ability to cause growth retardation upon transgenic overexpression in mice depends on its proteinase inhibitory function.
The Stc2 promoter contains multiple putative xenobiotic response elements.
These results suggest that the up-regulation of STC2 gene expression resulting from abnormal alpha-klotho (zeige KL Proteine)-Fgf23 (zeige FGF23 Proteine) signaling may contribute to limitation of ectopic calcification.
These results define a novel molecular function for STC2 as a negative modulator of Store-Operated Calcium Entry and provide the first direct evidence for the regulation of Ca2 (zeige CA2 Proteine)+ homeostasis by mammalian STC2.
STC2 is linked to PERK signalling in acinar cells and has a role in limiting damage during pancreatic injury.
induced STC2 expression is an essential feature of survival component of the unfolded-protein response
The murine stanniocalcin 2 gene is a negative regulator of postnatal growth.
This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction, reduced bone and skeletal muscle growth, and organomegaly. Expression of this gene is induced by estrogen and altered in some breast cancers.
, STC-related protein
, stanniocalcin-related protein