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analysis of the interaction mechanism of INSL5 with its receptor RXFP4
High serum INSL5 is associated with obesity in men.
The C-terminus of the B-chain of human INSL5 is critical for cognate RXFP4 receptor activity.
Insl5 is an orexigenic hormone released from colonic L-cells, which promotes appetite during conditions of energy deprivation.
electrostatic interactions between INSL5 and RXFP4
High INSL5 expression is associated with enteroendocrine cells of the neuroendocrine tumors.
INSL5 may be a unique marker of colorectal enteroendocrine cells, and INSL5-RXFP4 signaling might play a role in an autocrine/paracrine fashion in the colorectal epithelium and rectal neuroendocrine tumors.
Insulin-like peptide 5 is an endogenous ligand for GPCR142
The hydrogen-bond network and electrostatic interactions between charged groups in INSL5 by NMR-monitored temperature and pH titrations was characterized.
Insl5 knockout mice displayed impaired male and female fertility that are due to marked reduction in sperm motility and irregular length of the estrous cycle. Also impaired glucose homeostasis due to glucose intolerance.
Insulin-like peptide 5 is expressed in mouse brain and has a role in mobilization of calcium
The protein encoded by this gene contains a classical signature of the insulin superfamily and is highly similar to relaxin 3 (RLN3/INSL7).
insulin-like peptide 5
, insulin-like peptide INSL5
, relaxin/insulin-like factor 2
, relaxin/insulin-like protein