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Human IGF2 Protein expressed in Escherichia coli (E. coli) - ABIN413415
Wang, Rayes, Elahi, Lu, Hancock, Massie, Rowe, Aomari, Hossain, Durocher, Pinard, Tabariès, Siegel, Brodt: The IGF-Trap: Novel Inhibitor of Carcinoma Growth and Metastasis. in Molecular cancer therapeutics 2015
Analysis of patient serum samples showed that concurrent elevation of insulin like growth factor 2 (IGF2) and vascular endothelial growth factor (VEGF) levels may serve as a prognostic biomarker for oesophageal cancer.
Our results revealed that IGF-II promotes cell proliferation and EMT in HCC cells.
Serum preptin levels were significantly higher in women with polycystic ovary syndrome compared with controls.
infants with intrauterine growth restriction had higher serum levels of IGF2 if they had the A/G genotype at the ApaI restriction fragment length polymorphism and higher values of IGF2R if they had the A/A genotype
They retained the main IGF-1R-related properties, but the hormones with His49 in IGF-1 and His48 in IGF-2 showed significantly higher affinities for IR-A and for IR-B, being the strongest IGF-1- and IGF-2-like binders of these receptors ever reported.
Upregulation of IGF-II expression is associated with ovarian cancer.
Data suggest that high IGF2 DMR methylation status would be a phenomenon that is observed with the progression of gastric cancer (GC) toward more aggressive features, supporting their potential utility as a biomarker in GC patients.
Data suggest that expression of CDKN1C and IGF2 is significantly up-regulated in placenta after assisted reproductive technology; DNA methylation was significantly down-regulated in DMR of CDKN1C and up-regulated in DMR of IGF2. (CDKN1C = cyclin-dependent kinase inhibitor-1C; IGF2 = insulin like growth factor 2; DMR = differential methylation regions)
The expression of miR-3941 was significantly down-regulated in acute pneumonia; IGF2 was confirmed as a direct target gene of miR-3941.
Our data reveal that vigilin is essential for maintenance of imprinting of IGF2 gene via functional interaction between KH1-7 domains of vigilin and zinc-finger domains of CTCF.
Low IGF-II serum levels were associated with Pancreatic Cancer.
Rapamycin-independent IGF2 expression in Tsc2-null mouse embryo fibroblasts and human lymphangioleiomyomatosis cells.
IGF2 rs680 polymorphism may have a role in endurance among Israeli athletes
low methylation of the Igf2 gene promoter region may promote the expression of Igf2 and miR4835p; this, in turn, induces the degradation of miR4835p target genes, and leads to the upregulation of oncogenes and the downregulation of tumor suppressors, which promotes the development of ESCC.
autocrine IGF2 constitutively activated IGF1R and Akt phosphorylation, which was inhibited by BI 885578 treatment. BI 885578 significantly delayed the growth of IGF2-high colorectal cancer xenograft tumors in mice, while combination with a VEGF-A antibody increased efficacy and induced tumor regression.
These findings demonstrated that hMSCCMmediated neuroprotection was attributed to IGF1Rmediated signaling, potentiated via the inhibition of IGF2 by IGFBP6. The results of the present study provide insight into the mechanism by which hMSC administration may promote recovery from nerve injury.
Results found IGF2 as a direct target gene of miR615 and restoring its expression reverses the inhibitory effects of miR615 in human esophageal squamous cell carcinoma cell motility.
A common indel variant in the 3'UTR of the IGF2 gene was associated with the risk of impaired renal function in an elderly population.
High molecular weight IGF-2 was associated with hypoglycemia in Recurrent Renal Cell Carcinoma.
Impairment of IGF2 gene expression in prostate cancer is triggered by epigenetic dysregulation of IGF2-DMR0 and its interaction with KLF4
ith respect to the different IGFs produced locally, a decrease in igf1a expression and a significant increase in both igf2a and igf2b expression was observed, suggesting that igf1a is not directly involved in fin regeneration. Overall, the results revealed that excess GH enhances fin regeneration in zebrafish through igf2a and igf2b expression, acting indirectly on this major physiological process.
Igf2 regulates early neural and cardiovascular development in zebrafish embryos.
The IGF2 expression has also been reported at earlier stages in fish.
zebrafish orthologs of IGF2 function in dorsal midline development during segmentation/neurulation, whereas one paralog, igf2b, has evolved additional, distinct functions during subsequent organogenesis.
Myogenesis-associated long noncoding rna promotes myogenesis by functioning as a competing endogenous RNA for microRNA-125b to control protein abundance of IGF2.
DIS3L2 loss of function results in transcriptional activation of the Igf2/H19 locus in nephron progenitor cells, most likely by leading to the activation of shared cis-regulatory elements that control these genes.
the effect of ZBED6 on growth of muscle and internal organs is mediated through the binding site in the Igf2 gene
HMGA1P7 mRNA sustains the H19 and Igf2 overexpression by acting as miRNA decoy.
IGF-II-mediated loss of E-cadherin is central in developing hepatomegaly in mice and abnormal cell growth in the hepatoma cell line
IGF2 is silenced in mouse embryos by the zinc finger protein ZFP568
Loss of imprinting at the Igf2/H19 locus disrupts in vitro differentiation of primary myoblasts.
Epithelial IGF1R is dispensable for IGF2-mediated enhanced intestinal adaptation after small bowel resection in retinoblastoma-deficient mice.
These findings indicate that IGF-II reduces PGC-1alpha expression in skeletal muscle cells through a mechanism involving PI3K-Akt-FoxO1 but not p38 MAPK or Erk1/2 MAPK pathways.
produced by pericentral hepatocytes to promote hepatocyte proliferation and repair tissue damage in the setting of chronic liver injury
Here the authors show that fibroblast growth factor 22 (FGF22), a target-derived presynaptic organizer in the mouse hippocampus, induces the expression of insulin-like growth factor 2 (IGF2) for the stabilization of presynaptic terminals.
Loss of Igf2 Gene Imprinting is associated with Prostate Cancer.
IGF2 controls bone growth by regulating glucose metabolism in chondrocytes.
These results demonstrate that overexpressed IGF-2 is the major tumorigenic driver in a subset of CRCs and encourage testing of MEDI-573, alone and in combinations, in IGF2-overexpressing CRC patients.
results demonstrate that the H19-Igf2 axis is negatively regulated by CTCF-PHB1 cooperation and that H19 is involved in modulating the growth-suppressive effect of PHB1 in the liver.
Our study reveals that the expression level of Igf2 is critical to maintain the balance between stem cell self-renewal and differentiation, presumably by regulating the interaction between HSC and their niche.
To test the tumorigenic potential of different cell types in the developing kidney, we used kidney progenitor-specific Cre recombinase alleles to introduce Wt1 and Ctnnb1 mutations, two alterations observed in Wilms tumor, into embryonic mouse kidney, with and without biallelic Igf2 expression, another alteration that is observed in a majority of tumors
This study demonstrated that the Decreased IDE and IGF2 expression in the cerebral cortex of pups by early life lead exposure.
analysis of the distal muscle enhancer in the mouse Igf2 locus
These results indicated that editing IGF2 intron 3-3072 site using CRISPR-Cas9 technology improved meat production in Bama pigs.
trans-associations occur between three imprinted genes IGF2, DLK1 and MEG3 both in fetal liver and muscle cells.
A single nucleotide polymorphism in a regulatory region of intron 3 within the porcine IGF2 gene is associated with increased lean deposition and decreased fat deposition in pigs with paternal A alleles compared with pigs with paternal G alleles.
These findings indicated that the mRNA of H19 and IGF2 genes is susceptible to in vitro environments during the process of ES cell derivation from blastocysts but DNA methylation status at this region was well maintained.
study did not find any significant associations for polymorphisms in insulin-like grwoth factor 2, GTP Binding Protein alpha Subunits, Gs and melanocortin receptor 4 genes with reproductive traits of Polish Landrace and Large White pigs
The results suggested that IFG-1 and -2 and their receptors are differentially expressed at the maternal and fetal components of the attachment site.
Genetic variation in the promoter region of the IGF2 gene is associated with intramuscular fat content in porcine skeletal muscle.
The IGF2 G allele has strong adipogenic effects at the subcutaneous adipose tissue level and enhances the intermuscular fat content in ham.
IGF-I, IGF-II, and IGFBP-3 mRNA were positively correlated with IGF-IR from 50E to 180D, suggesting that the expression of IGF-system genes exhibits specific developmental patterns in the skeletal muscle tissues.
The imprinting status in adult liver, muscle and kidney tissues were also not reflected in the methylation patterns of IGF2 DMRs 1 and 2.
The expression of IGF-I and IGF-II in native growth plates of prepubertal piglets and under different cell culture conditions, was compared.
The aim of this work was to study the effects on litter size of variants of the porcine genes RBP4, ESR1 and IGF2, currently used in genetic tests for different purposes.
Promoter-specific expression differences of IGF2 isoforms and IGF2AS between biparental and parthenogenetic swine fetal tissues were documented. IGF2 and IGF2AS are paternally expressed.
In both skeletal muscle and heart muscle growth, the insulin-like growth factor-2:myostatin interaction seems to play an important role.
Effect of genotype on proteolytic enzyme in skeletal muscles during growth.
Mutation controls the paternally expressed QTL for backfat thickness in a cross between Meishan and European Whites.
A significant effect of linkage disequilibrium between IGF2-in3-G3072A and IGF2-in7-G162C on backfat thickness and lean meat content was found.
Results showed that in IGF2 gene, the predominant allele was C, and the predominant genotype was CC. and that Wuzhishan pig breed was at Hardy-Weinberg equilibrium with respect to this SNP.
The majority of IGF2 transcripts are expressed from promoters 2-4 and are imprinted.
IGF2 gene has significant effects on individual birth weight and backfat thickness
Methylation pattern in a CpG island of the IGF2 gene in cumulus cells from 1-3 mm and >/= 8.0 mm follicles and the effects of in vitro maturation on this pattern.
Our results provide evidence that polymorphisms in the IGF2 gene are associated with growth traits, and may be used for marker-assisted selection in beef cattle breeding program
The identification of the polymorphisms in the IGF2 gene that were significantly associated with growth traits in cattle.
Polymorphisms in the IGF2 gene are associated with cattle growth traits.
The LEP, IGF2 and CCL2 genes showed allelic expression imbalance in liver, kidney and pituitary glands of Polish Holstein-Friesian bulls.
Sex-sorting procedure by flow cytometry did not affect the overall DNA methylation patterns of the IGF2 and IGF2R genes, although individual variation in their methylation patterns among bulls was observed.
The reduction in IGFs mRNA level after 5 days of life in the duodenum (IGF-1 and IGF-2) and in the jejunum (IGF-1) was associated with reduction in villi length (duodenum and jejunum) and the increase of crypt depth (duodenum).
Changes in the methylation pattern of IGF2 during in vitro maturation were different between incompetent and competent oocytes, and this characteristic may be useful as a molecular marker in studies of oocyte competence in cattle.
Data describes the long-term changes to skeletal muscle growth and IGF1, 2, 1R, and 2R mRNA expression in progeny after exposure to high and low levels of maternal nutrient intake during the first two trimesters of gestation in the bovine.
findings support work which suggests that the insulin-like growth factor 2 locus is an important biological regulator of milk production in dairy cattle
effects of insulin, IGF-I and IGF-II on apoptosis and cell proliferation in bovine blastocysts in vitro
IGF2 is subjected to extensive transcriptional regulation through multiple promoters, alternative splicing and polyadenylation, as well as genetic imprinting.IGF2 regulation is age-, tissue-, promoter-, and allele-specific
Identification of a previously unknown differentially methylated region in exon 10 of the bovine IGF2 gene.
Indel polymorphism associated with breeding value in bulls.
The role of insulin-like growth factor 2 (IGF2) and the regulation of the IGF2 receptor (IGF2R) during follicular development were studied.
Embryonic tissues from NT-derived embryos had higher expression of IGF-II mRNA than in vitro production embryonic tissues.
The effect of single nucleotide polymorphisms in 6 genes and their associations with production factors in beef cattle are reported.
study to assess the mRNA expression of IGF-I, IGF-II, IGF-IR and IGF-IIR in bovine oocytes and different stages of preimplantation embryos
Dats detected that SNPs of IGF2 gene has close relationship with carcass and meat quality traits in Qinchuan cattle
Hypomethylation trends in the intergenic region of the imprinted IGF2 and H19 genes in cloned cattle.
increased endogenous IGF1 and IGF2 expression by the blastocyst compensates for the loss of systemic insulin and IGF.
Data suggest that metabolism of IGF1, IGF2, and IGFBP3 (insulin-like growth factor binding protein-3) can be altered by dietary modifications (here, long-term caloric restriction in Welsh Pony mares).
Methylation of three selected CpG islands of promoter of equine IGF2 gene was comparable between young and old horses, suggesting that aging could not be considered as a factor modulating methylation status of selected CpG islands within equine IGF2 gene.
This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
insulin-like growth factor II
, insulin-like growth factor type 2
, insulin-like growth factor 2
, insulin-like growth factor 2b
, insulin-like growth factor 2-A
, insulin-like growth factor II-A
, multiplication-stimulating polypeptide
, Insulin-like growth factor II (somatomedin A)
, insulin-like growth factor II (IGF-II)
, insulin-like growth factor II isoform 2 variant 4 preprotein
, multiplication-stimulating activity
, insulin growth factor 2
, insulin-like growth factor-II
, prepro-insulin-like growth factor-II
, Insulin-like growth factor 2-B
, insulin-like growth factor 2 (somatomedin A)
, insulin-like growth factor 2-B
, insulin-like growth factor II-B
, Insulin-like growth factor II-B