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Human IGF2 Protein expressed in Escherichia coli (E. coli) - ABIN413415
Wang, Rayes, Elahi, Lu, Hancock, Massie, Rowe, Aomari, Hossain, Durocher, Pinard, Tabariès, Siegel, Brodt: The IGF-Trap: Novel Inhibitor of Carcinoma Growth and Metastasis. in Molecular cancer therapeutics 2015
Results found the expression levels of IGF2 and CD133 positively correlated with each other in primary esophageal squamous cell carcinoma (ESSC), and their concurrent increased expression was significantly associated with poor patient survival. Knockdown of IGF2 or treatment with PI3K/AKT inhibitors markedly inhibited the abilities of CD133-positive ESCC cells to self-renew, resist chemotherapeutic drugs, and form tumors.
Study provide evidence that the enhancer at IGF2 regulates the rate-limiting enzyme in dopamine synthesis tyrosine hydroxylase (TH). This work suggests a mechanism for epigenetic regulation of dopamine levels in the brain. Epigenetic misregulation of an enhancer at IGF2 may underlie the dopaminergic abnormalities that drives psychotic symptoms.
An association was found between IGF2 methylation in maternal blood and birth weight.
This study was planned to test whether follicular fluid (FF) levels of patatin-like phospholipase domain containing 3-gene (PNPLA3:adiponutrin), preptin, kisspeptin, and amylin change in polycystic ovarian syndrome.
Long noncoding RNA insulin growth factor 2 antisense is acting as an epigenetic tumor suppressor in human prostate cancer, likely through inverse regulation on IGF2
IGFBP6 controls the expansion of chemoresistant glioblastoma through paracrine IGF2/IGF-1R signaling
These findings not only confirm the role of the hypothalamic-pituitary-gonadal axis in the genetic regulation of menstrual cycle length but also highlight potential novel local regulatory mechanisms, such as those mediated by IGF2.
Results showed significant correlation between ROS levels and H19-Igf2 gene methylation as well as semen parameters. These findings are critical to identify idiopathic male infertility and its management through assisted reproduction technology
in LOI cells, we find a reversal of the relative activities of two canonical signaling pathways triggered by IGF2, causing further rebalancing between pro- and anti-apoptotic signaling.
findings uncovered the mechanistic basis for differential HIF-1alpha-mediated regulation of BNIP3 and IGF2, indicating that copper regulates target gene selectivity of HIF-1alpha at least in part by affecting HIF-1alpha binding to its cognate HRE in the promoters of these two genes
Methylation levels of IGF2 DMR regions are associated with total body fat and with fat distribution in the viscera and liver of postmenopausal women.
miR-615-3p played important roles in the regulation of NSCLC growth and metastasis by targeting IGF2.
Study demonstrated that HOTTIP expression was significantly upregulated in renal cell carcinoma (RCC) and was associated with a shorter survival. The inhibition of HOTTIP suppressed cell proliferation, migration and invasion in RCC. In addition, IFG-2 was found to be a direct target gene of HOTTIP. HOTTIP directly bound to miR-615 and effectively acted as a sponge for miR-615 to modulate the suppression of IFG-2.
IGF2 expression in prostate cancer is independent of the imprinting status of the IGF2-H19 locus, but rather depends on differential methylation and usage of promoter-specific.
IGF2 polymorphism is associated with neoplasms.
serum preptin levels in women decrease after menopause and have a positive correlation with estradiol, femoral and total hip bone mineral density.
Analysis of patient serum samples showed that concurrent elevation of insulin like growth factor 2 (IGF2) and vascular endothelial growth factor (VEGF) levels may serve as a prognostic biomarker for oesophageal cancer.
Our results revealed that IGF-II promotes cell proliferation and EMT in HCC cells.
Serum preptin levels were significantly higher in women with polycystic ovary syndrome compared with controls.
infants with intrauterine growth restriction had higher serum levels of IGF2 if they had the A/G genotype at the ApaI restriction fragment length polymorphism and higher values of IGF2R if they had the A/A genotype
ith respect to the different IGFs produced locally, a decrease in igf1a expression and a significant increase in both igf2a and igf2b expression was observed, suggesting that igf1a is not directly involved in fin regeneration. Overall, the results revealed that excess GH enhances fin regeneration in zebrafish through igf2a and igf2b expression, acting indirectly on this major physiological process.
Igf2 regulates early neural and cardiovascular development in zebrafish embryos.
The IGF2 expression has also been reported at earlier stages in fish.
zebrafish orthologs of IGF2 function in dorsal midline development during segmentation/neurulation, whereas one paralog, igf2b, has evolved additional, distinct functions during subsequent organogenesis.
HIF-1 alpha: a key survival factor for serum-deprived prostate cancer cells.
Study discovered that light-induced enhancement of recognition memory occurs in tandem with pronounced changes in hippocampal genetic programs as up-regulation of Igf2, and proposes that light-induced changes in hippocampal clock function leads to the de-repression of IGF2, which primes the hippocampus to enhance the acquisition and consolidation of long-term recognition memory.
Myogenesis-associated long noncoding rna promotes myogenesis by functioning as a competing endogenous RNA for microRNA-125b to control protein abundance of IGF2.
DIS3L2 loss of function results in transcriptional activation of the Igf2/H19 locus in nephron progenitor cells, most likely by leading to the activation of shared cis-regulatory elements that control these genes.
the effect of ZBED6 on growth of muscle and internal organs is mediated through the binding site in the Igf2 gene
Rapamycin-independent IGF2 expression in Tsc2-null mouse embryo fibroblasts and human lymphangioleiomyomatosis cells.
HMGA1P7 mRNA sustains the H19 and Igf2 overexpression by acting as miRNA decoy.
IGF-II-mediated loss of E-cadherin is central in developing hepatomegaly in mice and abnormal cell growth in the hepatoma cell line
IGF2 is silenced in mouse embryos by the zinc finger protein ZFP568
Loss of imprinting at the Igf2/H19 locus disrupts in vitro differentiation of primary myoblasts.
Epithelial IGF1R is dispensable for IGF2-mediated enhanced intestinal adaptation after small bowel resection in retinoblastoma-deficient mice.
These findings indicate that IGF-II reduces PGC-1alpha expression in skeletal muscle cells through a mechanism involving PI3K-Akt-FoxO1 but not p38 MAPK or Erk1/2 MAPK pathways.
produced by pericentral hepatocytes to promote hepatocyte proliferation and repair tissue damage in the setting of chronic liver injury
Here the authors show that fibroblast growth factor 22 (FGF22), a target-derived presynaptic organizer in the mouse hippocampus, induces the expression of insulin-like growth factor 2 (IGF2) for the stabilization of presynaptic terminals.
Loss of Igf2 Gene Imprinting is associated with Prostate Cancer.
IGF2 controls bone growth by regulating glucose metabolism in chondrocytes.
These results demonstrate that overexpressed IGF-2 is the major tumorigenic driver in a subset of CRCs and encourage testing of MEDI-573, alone and in combinations, in IGF2-overexpressing CRC patients.
results demonstrate that the H19-Igf2 axis is negatively regulated by CTCF-PHB1 cooperation and that H19 is involved in modulating the growth-suppressive effect of PHB1 in the liver.
Our study reveals that the expression level of Igf2 is critical to maintain the balance between stem cell self-renewal and differentiation, presumably by regulating the interaction between HSC and their niche.
To test the tumorigenic potential of different cell types in the developing kidney, we used kidney progenitor-specific Cre recombinase alleles to introduce Wt1 and Ctnnb1 mutations, two alterations observed in Wilms tumor, into embryonic mouse kidney, with and without biallelic Igf2 expression, another alteration that is observed in a majority of tumors
Our study confirmed the important effect of a mutation in the ZBED6 binding site motif on IGF2 expression and myogenesis, thus providing the basis for breeding a new line of Liang Guang Small Spotted pigs with improved lean meat percentage, a trait of great commercial value to pig producers.
These results indicated that editing IGF2 intron 3-3072 site using CRISPR-Cas9 technology improved meat production in Bama pigs.
trans-associations occur between three imprinted genes IGF2, DLK1 and MEG3 both in fetal liver and muscle cells.
A single nucleotide polymorphism in a regulatory region of intron 3 within the porcine IGF2 gene is associated with increased lean deposition and decreased fat deposition in pigs with paternal A alleles compared with pigs with paternal G alleles.
These findings indicated that the mRNA of H19 and IGF2 genes is susceptible to in vitro environments during the process of ES cell derivation from blastocysts but DNA methylation status at this region was well maintained.
study did not find any significant associations for polymorphisms in insulin-like grwoth factor 2, GTP Binding Protein alpha Subunits, Gs and melanocortin receptor 4 genes with reproductive traits of Polish Landrace and Large White pigs
The results suggested that IFG-1 and -2 and their receptors are differentially expressed at the maternal and fetal components of the attachment site.
Genetic variation in the promoter region of the IGF2 gene is associated with intramuscular fat content in porcine skeletal muscle.
The IGF2 G allele has strong adipogenic effects at the subcutaneous adipose tissue level and enhances the intermuscular fat content in ham.
IGF-I, IGF-II, and IGFBP-3 mRNA were positively correlated with IGF-IR from 50E to 180D, suggesting that the expression of IGF-system genes exhibits specific developmental patterns in the skeletal muscle tissues.
The imprinting status in adult liver, muscle and kidney tissues were also not reflected in the methylation patterns of IGF2 DMRs 1 and 2.
The expression of IGF-I and IGF-II in native growth plates of prepubertal piglets and under different cell culture conditions, was compared.
The aim of this work was to study the effects on litter size of variants of the porcine genes RBP4, ESR1 and IGF2, currently used in genetic tests for different purposes.
Promoter-specific expression differences of IGF2 isoforms and IGF2AS between biparental and parthenogenetic swine fetal tissues were documented. IGF2 and IGF2AS are paternally expressed.
In both skeletal muscle and heart muscle growth, the insulin-like growth factor-2:myostatin interaction seems to play an important role.
Effect of genotype on proteolytic enzyme in skeletal muscles during growth.
Mutation controls the paternally expressed QTL for backfat thickness in a cross between Meishan and European Whites.
A significant effect of linkage disequilibrium between IGF2-in3-G3072A and IGF2-in7-G162C on backfat thickness and lean meat content was found.
Results showed that in IGF2 gene, the predominant allele was C, and the predominant genotype was CC. and that Wuzhishan pig breed was at Hardy-Weinberg equilibrium with respect to this SNP.
The majority of IGF2 transcripts are expressed from promoters 2-4 and are imprinted.
Methylation pattern in a CpG island of the IGF2 gene in cumulus cells from 1-3 mm and >/= 8.0 mm follicles and the effects of in vitro maturation on this pattern.
Our results provide evidence that polymorphisms in the IGF2 gene are associated with growth traits, and may be used for marker-assisted selection in beef cattle breeding program
The identification of the polymorphisms in the IGF2 gene that were significantly associated with growth traits in cattle.
Polymorphisms in the IGF2 gene are associated with cattle growth traits.
The LEP, IGF2 and CCL2 genes showed allelic expression imbalance in liver, kidney and pituitary glands of Polish Holstein-Friesian bulls.
Sex-sorting procedure by flow cytometry did not affect the overall DNA methylation patterns of the IGF2 and IGF2R genes, although individual variation in their methylation patterns among bulls was observed.
The reduction in IGFs mRNA level after 5 days of life in the duodenum (IGF-1 and IGF-2) and in the jejunum (IGF-1) was associated with reduction in villi length (duodenum and jejunum) and the increase of crypt depth (duodenum).
Changes in the methylation pattern of IGF2 during in vitro maturation were different between incompetent and competent oocytes, and this characteristic may be useful as a molecular marker in studies of oocyte competence in cattle.
Data describes the long-term changes to skeletal muscle growth and IGF1, 2, 1R, and 2R mRNA expression in progeny after exposure to high and low levels of maternal nutrient intake during the first two trimesters of gestation in the bovine.
findings support work which suggests that the insulin-like growth factor 2 locus is an important biological regulator of milk production in dairy cattle
effects of insulin, IGF-I and IGF-II on apoptosis and cell proliferation in bovine blastocysts in vitro
IGF2 is subjected to extensive transcriptional regulation through multiple promoters, alternative splicing and polyadenylation, as well as genetic imprinting.IGF2 regulation is age-, tissue-, promoter-, and allele-specific
Identification of a previously unknown differentially methylated region in exon 10 of the bovine IGF2 gene.
Indel polymorphism associated with breeding value in bulls.
The role of insulin-like growth factor 2 (IGF2) and the regulation of the IGF2 receptor (IGF2R) during follicular development were studied.
Embryonic tissues from NT-derived embryos had higher expression of IGF-II mRNA than in vitro production embryonic tissues.
The effect of single nucleotide polymorphisms in 6 genes and their associations with production factors in beef cattle are reported.
study to assess the mRNA expression of IGF-I, IGF-II, IGF-IR and IGF-IIR in bovine oocytes and different stages of preimplantation embryos
Dats detected that SNPs of IGF2 gene has close relationship with carcass and meat quality traits in Qinchuan cattle
Hypomethylation trends in the intergenic region of the imprinted IGF2 and H19 genes in cloned cattle.
increased endogenous IGF1 and IGF2 expression by the blastocyst compensates for the loss of systemic insulin and IGF.
Data suggest that metabolism of IGF1, IGF2, and IGFBP3 (insulin-like growth factor binding protein-3) can be altered by dietary modifications (here, long-term caloric restriction in Welsh Pony mares).
Methylation of three selected CpG islands of promoter of equine IGF2 gene was comparable between young and old horses, suggesting that aging could not be considered as a factor modulating methylation status of selected CpG islands within equine IGF2 gene.
This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
insulin-like growth factor II
, insulin-like growth factor type 2
, insulin-like growth factor 2
, insulin-like growth factor 2b
, insulin-like growth factor 2-A
, insulin-like growth factor II-A
, multiplication-stimulating polypeptide
, Insulin-like growth factor II (somatomedin A)
, insulin-like growth factor II (IGF-II)
, insulin-like growth factor II isoform 2 variant 4 preprotein
, multiplication-stimulating activity
, insulin growth factor 2
, insulin-like growth factor-II
, prepro-insulin-like growth factor-II
, Insulin-like growth factor 2-B
, insulin-like growth factor 2 (somatomedin A)
, insulin-like growth factor 2-B
, insulin-like growth factor II-B
, Insulin-like growth factor II-B