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Human IGF2 Protein expressed in Escherichia coli (E. coli) - ABIN413415
Wang, Rayes, Elahi, Lu, Hancock, Massie, Rowe, Aomari, Hossain, Durocher, Pinard, Tabariès, Siegel, Brodt: The IGF-Trap: Novel Inhibitor of Carcinoma Growth and Metastasis. in Molecular cancer therapeutics 2015
Our results revealed that IGF-II promotes cell proliferation and EMT (zeige ITK Proteine) in HCC (zeige FAM126A Proteine) cells.
Serum preptin levels were significantly higher in women with polycystic ovary syndrome compared with controls.
infants with intrauterine growth restriction had higher serum levels of IGF2 if they had the A/G genotype at the ApaI restriction fragment length polymorphism and higher values of IGF2R (zeige IGF2R Proteine) if they had the A/A genotype
They retained the main IGF-1R-related properties, but the hormones with His49 in IGF-1 and His48 in IGF-2 showed significantly higher affinities for IR-A and for IR-B, being the strongest IGF-1- and IGF-2-like binders of these receptors ever reported.
Upregulation of IGF-II expression is associated with ovarian cancer.
Data suggest that high IGF2 DMR (zeige WDR20 Proteine) methylation status would be a phenomenon that is observed with the progression of gastric cancer (GC) toward more aggressive features, supporting their potential utility as a biomarker in GC patients.
Data suggest that expression of CDKN1C (zeige CDKN1C Proteine) and IGF2 is significantly up-regulated in placenta after assisted reproductive technology; DNA methylation (zeige HELLS Proteine) was significantly down-regulated in DMR (zeige WDR20 Proteine) of CDKN1C (zeige CDKN1C Proteine) and up-regulated in DMR (zeige WDR20 Proteine) of IGF2. (CDKN1C (zeige CDKN1C Proteine) = cyclin-dependent kinase inhibitor-1C (zeige CDKN1C Proteine); IGF2 = insulin like growth factor 2; DMR (zeige WDR20 Proteine) = differential methylation regions)
The expression of miR (zeige MLXIP Proteine)-3941 was significantly down-regulated in acute pneumonia; IGF2 was confirmed as a direct target gene of miR (zeige MLXIP Proteine)-3941.
Our data reveal that vigilin (zeige HDLBP Proteine) is essential for maintenance of imprinting of IGF2 gene via functional interaction between KH1 (zeige KCNF1 Proteine)-7 domains of vigilin (zeige HDLBP Proteine) and zinc-finger domains of CTCF (zeige CTCF Proteine).
Low IGF-II serum levels were associated with Pancreatic Cancer.
ith respect to the different IGFs produced locally, a decrease in igf1a (zeige IGF1 Proteine) expression and a significant increase in both igf2a and igf2b expression was observed, suggesting that igf1a (zeige IGF1 Proteine) is not directly involved in fin regeneration. Overall, the results revealed that excess GH enhances fin regeneration in zebrafish through igf2a and igf2b expression, acting indirectly on this major physiological process.
Igf2 regulates early neural and cardiovascular development in zebrafish embryos.
The IGF2 expression has also been reported at earlier stages in fish.
zebrafish orthologs of IGF2 function in dorsal midline development during segmentation/neurulation, whereas one paralog, igf2b, has evolved additional, distinct functions during subsequent organogenesis.
DIS3L2 (zeige DIS3L2 Proteine) loss of function results in transcriptional activation of the Igf2/H19 (zeige NCKAP1 Proteine) locus in nephron progenitor cells, most likely by leading to the activation of shared cis (zeige CISH Proteine)-regulatory elements that control these genes.
the effect of ZBED6 on growth of muscle and internal organs is mediated through the binding site in the Igf2 gene
Rapamycin-independent IGF2 expression in Tsc2-null mouse embryo fibroblasts and human lymphangioleiomyomatosis cells.
HMGA1P7 mRNA sustains the H19 and Igf2 overexpression by acting as miRNA decoy.
IGF-II-mediated loss of E-cadherin (zeige CDH1 Proteine) is central in developing hepatomegaly in mice and abnormal cell growth in the hepatoma cell line
IGF2 is silenced in mouse embryos by the zinc finger protein ZFP568
Loss of imprinting at the Igf2/H19 (zeige NCKAP1 Proteine) locus disrupts in vitro differentiation of primary myoblasts.
Epithelial IGF1R is dispensable for IGF2-mediated enhanced intestinal adaptation after small bowel resection in retinoblastoma-deficient mice.
These findings indicate that IGF-II reduces PGC-1alpha expression in skeletal muscle cells through a mechanism involving PI3K-Akt (zeige AKT1 Proteine)-FoxO1 (zeige FOXO1 Proteine) but not p38 MAPK (zeige MAPK14 Proteine) or Erk1/2 MAPK (zeige MAPK1 Proteine) pathways.
Here the authors show that fibroblast growth factor 22 (FGF22 (zeige FGF22 Proteine)), a target-derived presynaptic organizer in the mouse hippocampus, induces the expression of insulin-like growth factor 2 (IGF2) for the stabilization of presynaptic terminals.
trans-associations occur between three imprinted genes IGF2, DLK1 and MEG3 both in fetal liver and muscle cells.
A single nucleotide polymorphism in a regulatory region of intron 3 within the porcine IGF2 gene is associated with increased lean deposition and decreased fat deposition in pigs with paternal A alleles compared with pigs with paternal G alleles.
These findings indicated that the mRNA of H19 (zeige NCKAP1 Proteine) and IGF2 genes is susceptible to in vitro environments during the process of ES cell derivation from blastocysts but DNA methylation (zeige HELLS Proteine) status at this region was well maintained.
study did not find any significant associations for polymorphisms in insulin (zeige INS Proteine)-like grwoth factor 2, GTP Binding Protein (zeige RND1 Proteine) alpha Subunits, Gs and melanocortin receptor 4 (zeige MC4R Proteine) genes with reproductive traits of Polish Landrace and Large White pigs
The results suggested that IFG (zeige IFNG Proteine)-1 and -2 and their receptors are differentially expressed at the maternal and fetal components of the attachment site.
Genetic variation in the promoter region of the IGF2 gene is associated with intramuscular fat content in porcine skeletal muscle.
The IGF2 G allele has strong adipogenic effects at the subcutaneous adipose tissue level and enhances the intermuscular fat content in ham.
IGF-I (zeige IGF1 Proteine), IGF-II, and IGFBP-3 (zeige IGFBP3 Proteine) mRNA were positively correlated with IGF-IR from 50E to 180D, suggesting that the expression of IGF-system genes exhibits specific developmental patterns in the skeletal muscle tissues.
The imprinting status in adult liver, muscle and kidney tissues were also not reflected in the methylation patterns of IGF2 DMRs 1 and 2.
The expression of IGF-I and IGF-II in native growth plates of prepubertal piglets and under different cell culture conditions, was compared.
Methylation pattern in a CpG island of the IGF2 gene in cumulus cells from 1-3 mm and >/= 8.0 mm follicles and the effects of in vitro maturation on this pattern.
Our results provide evidence that polymorphisms in the IGF2 gene are associated with growth traits, and may be used for marker-assisted selection in beef cattle breeding program
The identification of the polymorphisms in the IGF2 gene that were significantly associated with growth traits in cattle.
Polymorphisms in the IGF2 gene are associated with cattle growth traits.
The LEP (zeige LEP Proteine), IGF2 and CCL2 (zeige CCL2 Proteine) genes showed allelic expression imbalance in liver, kidney and pituitary glands of Polish Holstein-Friesian bulls.
Sex-sorting procedure by flow cytometry did not affect the overall DNA methylation (zeige HELLS Proteine) patterns of the IGF2 and IGF2R (zeige IGF2R Proteine) genes, although individual variation in their methylation patterns among bulls was observed.
The reduction in IGFs mRNA level after 5 days of life in the duodenum (IGF-1 (zeige IGF1 Proteine) and IGF-2) and in the jejunum (IGF-1 (zeige IGF1 Proteine)) was associated with reduction in villi length (duodenum and jejunum) and the increase of crypt depth (duodenum).
Changes in the methylation pattern of IGF2 during in vitro maturation were different between incompetent and competent oocytes, and this characteristic may be useful as a molecular marker in studies of oocyte competence in cattle.
Data describes the long-term changes to skeletal muscle growth and IGF1 (zeige IGF1 Proteine), 2, 1R, and 2R mRNA expression in progeny after exposure to high and low levels of maternal nutrient intake during the first two trimesters of gestation in the bovine.
findings support work which suggests that the insulin-like growth factor 2 locus is an important biological regulator of milk production in dairy cattle
increased endogenous IGF1 (zeige IGF1 Proteine) and IGF2 expression by the blastocyst compensates for the loss of systemic insulin (zeige INS Proteine) and IGF.
Data suggest that metabolism of IGF1 (zeige IGF1 Proteine), IGF2, and IGFBP3 (insulin-like growth factor binding protein-3 (zeige IGFBP3 Proteine)) can be altered by dietary modifications (here, long-term caloric restriction in Welsh Pony mares).
Methylation of three selected CpG islands of promoter of equine IGF2 gene was comparable between young and old horses, suggesting that aging could not be considered as a factor modulating methylation status of selected CpG islands within equine IGF2 gene.
This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
insulin-like growth factor II
, insulin-like growth factor type 2
, insulin-like growth factor 2
, insulin-like growth factor 2b
, insulin-like growth factor 2-A
, insulin-like growth factor II-A
, multiplication-stimulating polypeptide
, Insulin-like growth factor II (somatomedin A)
, insulin-like growth factor II (IGF-II)
, insulin-like growth factor II isoform 2 variant 4 preprotein
, multiplication-stimulating activity
, insulin growth factor 2
, insulin-like growth factor-II
, prepro-insulin-like growth factor-II
, Insulin-like growth factor 2-B
, insulin-like growth factor 2 (somatomedin A)
, insulin-like growth factor 2-B
, insulin-like growth factor II-B
, Insulin-like growth factor II-B