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IFN epsilon protects macrophages against HIV infection through a type I IFN independent mechanism.
female sex workers decreased susceptibility to HIV-1 infection also have increased levels of IFNE gene and protein expression in the cervical epithelium
T Allele of nonsense polymorphism (rs2039381, Gln71Stop) of interferon-epsilon is a risk factor for the development of intracerebral hemorrhage.
Full-length IFN-epsilon 5'UTR markedly suppressed mRNA expression under basal conditions. It contains 2 stable stem-loop structures which associate with importin 9 (zeige IPO9 Proteine). Loop 1 is essential for regulation of mRNA expression.
genetic polymorphism is related to onset time of vitiligo (zeige MITF Proteine) in Korean patients
The structue and mRNA expression pattern of IFN-epsilon1 suggest that it may have a function distinct from those other members of type I INF (zeige GIF Proteine).
TNF-alpha (zeige TNF Proteine) leads to stabilization of IFN-epsilon mRNA, increased IFN-epsilon synthesis, engagement of type I IFNRs, increased STAT1 (zeige STAT1 Proteine) expression and phosphorylation, and up-regulation of retinoic acid-inducible gene-I (zeige DDX58 Proteine) expression
In macrophages IFN-tau increased the synthesis of 2',5'-oligoadenylate synthetase/RNase L (zeige RNASEL Proteine), MxA (zeige MX1 Proteine) protein, IL-10 (zeige IL10 Proteine) & IL-6 (zeige IL6 Proteine), but not of IL-1ss or TNF-alpha (zeige TNF Proteine).
IFN-epsilon is constitutively expressed by cells of the reproductive tract and is inefficiently secreted by fibroblasts and cell lines.
IFN-epsilon could promote migration of antigen-specific CD8 (zeige CD8A Proteine)(+)T cells to the gut (zeige GUSB Proteine).
Ifn-epsilon-deficient mice had increased susceptibility to infection of the female reproductive tract by the common sexually transmitted infections (STIs) herpes simplex virus 2 and Chlamydia muridarum.
Paracrine hormone primarily responsible for maternal recognition of pregnancy. Interacts with endometrial receptors, probably type I interferon receptors, and blocks estrogen receptor expression, preventing the estrogen-induced increase in oxytocin receptor expression in the endometrium. This results in the suppression of the pulsatile endometrial release of the luteolytic hormone prostaglandin F2-alpha, hindering the regression of the corpus luteum (luteolysis) and therefore a return to ovarian cyclicity. This, and a possible direct effect of IFN-tau on prostaglandin synthesis, leads in turn to continued ovarian progesterone secretion, which stimulates the secretion by the endometrium of the nutrients required for the growth of the conceptus. In summary, displays particularly high antiviral and antiproliferative potency concurrently with particular weak cytotoxicity, high antiluteolytic activity and immunomodulatory properties. In contrast with other IFNs, IFN-tau is not virally inducible.
, interferon epsilon
, interferon epsilon 1
, interferon epsilon-1
, interferon tau-1