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anti-Human Hepcidin Antikörper:
anti-Mouse (Murine) Hepcidin Antikörper:
anti-Rat (Rattus) Hepcidin Antikörper:
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Human Polyclonal Hepcidin Primary Antibody für WB - ABIN4892228
Bose, Megyesi, Shah, Hiatt, Hall, Karaduta, Swaminathan: Evidence Suggesting a Role of Iron in a Mouse Model of Nephrogenic Systemic Fibrosis. in PLoS ONE 2015
Human Polyclonal Hepcidin Primary Antibody für ELISA - ABIN450057
Ward, Roberts, Brookes, Joy, Martin, Ismail, Spychal, Iqbal, Tselepis: Increased hepcidin expression in colorectal carcinogenesis. in World journal of gastroenterology 2008
Human Polyclonal Hepcidin Primary Antibody für WB - ABIN2776909
Theurl, Theurl, Seifert, Mair, Nairz, Rumpold, Zoller, Bellmann-Weiler, Niederegger, Talasz, Weiss: Autocrine formation of hepcidin induces iron retention in human monocytes. in Blood 2008
Hepcidin can very well be utilized as a potential prognostic marker to follow patients with breast cancer metastatic to bone.
Data suggest that hematologic parameters in children consuming lacto-ovo vegetarian diets are comparable with those of control children, but ferritin (zeige FTL Antikörper) levels are lower; inclusion of novel serum biomarkers, soluble transferrin receptor and hepcidin, in nutritional assessment can better detect subclinical iron deficiency in children following vegetarian diet. This study was conducted in Poland with children ages 4.5-9 years.
results suggest that lower Hepcidin-25, as well as higher sTfR and sTfR/Hepcidin-25 ratio were significant predictors of favorable hemoglobin response within a month after IV administration of ferric carboxymaltose in patients with CKD
unreported iron metabolism-related genes in non-classic hereditary hemochromatosis (zeige HFE Antikörper) patients that were predicted to be potentially pathogenic were three novel mutations in TFR2 (zeige TFR2 Antikörper) [two missense (p.Leu750Pro and p.Ala777Val) and one intronic splicing mutation (c.967-1G>C)], one missense mutation in HFE (zeige HFE Antikörper) (p.Tyr230Cys), and one mutation in the 5'-UTR (zeige UTS2R Antikörper) of HAMP gene (c.-25G>A)
increased intracellular iron content in recombinant-TfR1 (zeige TFRC Antikörper) HepG2 cells did not increase hepcidin responses compared to wild-type cells, resembling hemochromatosis (zeige HFE Antikörper)
Review of the role of hepcidin in iron metabolism disorders.
The bone morphogenetic protein (BMP) pathway regulates expression of hepcidin through transcriptional activation via BMP-responsive elements (REs) 1 and 2 on the promoter. A search for GC-rich sequences on the hepcidin promoter indicated 13 regions across the distal (A to F), middle (G to I), and proximal (J to M) areas.
Of the non-HFE (zeige HFE Antikörper) forms of iron overload, TFR2 (zeige TFR2 Antikörper)-, HFE2 (zeige HFE2 Antikörper)-, and HAMP-related forms are predicted to be rare, with pathogenic allele frequencies in the range of 0.00007 to 0.0005. Significantly, SLC40A1 (zeige SLC40A1 Antikörper) variants that have been previously associated with autosomal-dominant ferroportin (zeige SLC40A1 Antikörper) disease were identified in several populations (pathogenic allele frequency 0.0004), being most prevalent among Africans
Data (including data from studies using knockout mice) suggest that MT2 (zeige MT2 Antikörper)/TMPRSS6 (zeige TMPRSS6 Antikörper) suppresses hepcidin expression in hepatocytes independently of HJV (zeige HFE2 Antikörper); MT2 (zeige MT2 Antikörper)/TMPRSS6 (zeige TMPRSS6 Antikörper) cleaves ALK2 (zeige ACRV1 Antikörper), ALK3 (zeige BMPR1A Antikörper), ACTRIIA (zeige ACVR2A Antikörper), BMPR2 (zeige BMPR2 Antikörper), HFE (zeige HFE Antikörper), and, to a lesser extent, HJV (zeige HFE2 Antikörper) and TFR2 (zeige TFR2 Antikörper); thus, MT2 (zeige MT2 Antikörper)/TMPRSS6 (zeige TMPRSS6 Antikörper) suppresses hepcidin expression by cleaving multiple components of the hepcidin induction pathway. (MT2 (zeige MT2 Antikörper)/TMPRSS6 (zeige TMPRSS6 Antikörper) = matriptase-2 (zeige TMPRSS6 Antikörper); HJV (zeige HFE2 Antikörper) = hemojuvelin (zeige HFE2 Antikörper))
two unrelated hepatocellular carcinoma patients bore the HAMP:c.-153C>T mutation at the heterozygous state, which is associated with increased risk of iron overload and severe hemochromatosis (zeige HFE Antikörper)
Serum hepcidin levels were measured by competitive ELISA in wild-type and Inhbb (zeige INHBB Antikörper)-/- mice at baseline and 4 hours after LPS (zeige TLR4 Antikörper) challenge. Although Smad1 (zeige SMAD1 Antikörper)/5/8 signaling is not activated by inflammatory stimuli in the absence of activin B (zeige Actbeta Antikörper), this has no impact on the induction of hepcidin expression.
Anti-hemojuvelin (zeige HFE2 Antikörper) antibody corrects anemia caused by inappropriately high hepcidin levels
hepcidin mRNA upregulation depends on M1 macrophage polarization
Our data provide evidence that the interplay of these two hormones could help improve the understanding of the pathogenesis of atherosclerosis and NAFLD (zeige TSC2 Antikörper).
downregulation of hepcidin by siRNA increased iron uptake in bone and liver, which aggravated unloading-induced bone loss.
These data suggest that, in Hjv (zeige HFE2 Antikörper)(-/-) females, Bmp6 (zeige BMP6 Antikörper) can provide a signal adequate to maintain hepcidin to a level sufficient to avoid extrahepatic iron loading.
The authors generated mice with cardiomyocyte-specific deletion of hepcidin, or knock-in of hepcidin-resistant ferroportin (zeige SLC40A1 Antikörper). They find that while both models maintain normal systemic iron homeostasis, the mice nonetheless develop fatal contractile and metabolic dysfunction as a consequence of cardiomyocyte iron deficiency.
Erythroferrone and matriptase-2 (zeige TMPRSS6 Antikörper) independently regulate hepcidin expression.
Acute tacrolimus treatment transiently increases hepcidin in wild-type mice. FKBP12 (zeige FKBP1A Antikörper) preferentially targets the BMP receptor (zeige BMPR1A Antikörper) ALK2 (zeige ACRV1 Antikörper). ALK2 (zeige ACRV1 Antikörper) mutants defective in binding FKBP12 (zeige FKBP1A Antikörper) increase hepcidin expression in a ligand-independent manner, through BMP-SMAD (zeige SMAD1 Antikörper) signaling.
Hamp1 mRNA and plasma hepcidin levels are not good predictors of tissue iron levels, at least in males
This study shows that hepcidin knockdown in zebrafish using morpholinos leads to iron overload.
The data also show that the antibacterial activity of hepcidin-2 depends upon the disulfide bridges.
data support an alternative mechanism for hepcidin regulation during zebrafish embryonic development, which is independent of hemojuvelin (zeige HFE2 Antikörper).
Hepcidin expression is regulated by a transferrin-a (zeige Tf Antikörper)-dependent pathway in the zebrafish embryo.
this study demonstrates that urine hepcidin-25 concentrations strongly correlate with hepatic hepcidin mRNA abundance, plasma hepcidin-25 levels, iron transferrin (zeige Tf Antikörper) saturation and non-heme liver iron levels.
Data suugest that hepcidin might had antiinflammatory function and is a candidate regulator of the cross-talk between iron regulation and inflammation.
report the full-length cDNA sequences of porcine hepcidin and liver-expressed antimicrobial peptide-2 (LEAP-2 (zeige LEAP2 Antikörper))
Hepcidin peptide is up-regulated by iron and bacterial components in the trout liver.
The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure.
, liver-expressed antimicrobial peptide 1
, putative liver tumor regressor
, hepcidin antimicrobial peptide 1
, hepcidin antimicrobial peptide
, antimicrobial peptide
, iron regulatory peptide
, preprohepcidin 1
, antimicrobial peptide hepcidin
, putative hepcidin antibacterial peptide