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The plasma ADM2 levels were inversely correlated with obesity in humans, and adipo-ADM2-transgenic (tg) mice displayed resista (zeige MAPK14 ELISA Kits)nce to high-fat diet-induced obesity with increased energy expenditure.
Mouse and human heart valves expressed mRNAs for the CRL (zeige IL31RA ELISA Kits) ligands adrenomedullin (zeige ADM ELISA Kits) (AM), adrenomedullin-2 (AM-2) and calcitonin gene-related peptide (CGRP (zeige CALCA ELISA Kits)) and for their receptor components, i.e., CRL (zeige IL31RA ELISA Kits) and receptor-activity-modifying proteins 1-3.
ADM-2 is a stress-inducible gene controlled by ATF-4 (zeige ATF4 ELISA Kits).
Intermedin1-53 may attenuate vascular calcification by upregulating alpha-Klotho (zeige KL ELISA Kits) via the calcitonin receptor (zeige CALCR ELISA Kits)/modifying protein complex and protein kinase A signaling.
Intermedin (IMD) derived from human cardiac microvascular endothelial cell and acting in a paracrine manner on cardiomyocytes, predominantly at AM1 receptors, is more likely to contribute to direct protection by endogenous IMD of cardiomyocytes against acute ischemia reperfusion injury.
Elevated plasma intermedin levels are independently associated with long-term recurrence and distant metastasis of prostate cancer.
ADM2 may contribute to the physiology of embryo implantation and placental growth via increasing MMP2 (zeige MMP2 ELISA Kits) and decreasing MUC1 (zeige MUC1 ELISA Kits) expression to facilitate trophoblast invasion.
Plasma intermedin and BNP levels were markedly higher in acute coronary syndrome patients than in healthy people.
High levels of ADM2 expression predict a poorer survival in patients with pancreatic adenocarcinoma.
TSH induced AM2/IMD expression in the thyroid gland and it could locally work as a potent vasodilator, resulting in the expansion of thyroid inter-follicular capillaries.
ADM2 enhances subcutaneous White Adipose Tissue beiging via a direct effect by activating the CRLR.RAMP1-cAMP/PKA and p38 MAPK (zeige MAPK14 ELISA Kits) pathways in white adipocytes and via an indirect effect by stimulating alternative M2 polarization in macrophages.
Mouse and human heart valves expressed mRNAs for the CRL ligands adrenomedullin (zeige ADM ELISA Kits) (AM), adrenomedullin-2 (AM-2) and calcitonin gene-related peptide (CGRP (zeige CALCA ELISA Kits)) and for their receptor components, i.e., CRL and receptor-activity-modifying proteins 1-3.
IMD reduces bone resorption by inhibiting osteoblast apoptosis, decreasing the RANKL/OPG (zeige TNFSF11 ELISA Kits) ratio and the expression of M-CSF (zeige CSF1R ELISA Kits), and inhibiting osteoclast maturation and differentiation.
Adrenomedullin-2/intermedin(8-47) ameliorates early ischemia/reperfusion injury in mouse lungs by protecting the integrity of the blood-air barrier and by potently reducing leukocyte influx into the alveolar space
Intermedin attenuates macrophage foam-cell formation via tristetraprolin (zeige ZFP36 ELISA Kits)-mediated degradation of CD36 (zeige CD36 ELISA Kits) mRNA.
increased stability of PTEN by intermedin leads to SR-A (zeige MSR1 ELISA Kits) inhibition in macrophages, which ameliorates foam-cell formation and atherosclerosis in apoE (zeige APOE ELISA Kits)(-/-) mice.
Data show that mechanical ventilation reduced the expression of receptor activity-modifying protein RAMP3 (zeige RAMP3 ELISA Kits), but not of intermedin (IMD), calcitonin receptor-like receptor (CRLR (zeige CALCRL ELISA Kits)), and RAMP1 (zeige RAMP1 ELISA Kits) and RAMP2 (zeige RAMP2 ELISA Kits).
Intermedin is a calcitonin/calcitonin (zeige CALCA ELISA Kits) gene-related peptide (zeige CALCA ELISA Kits) family peptide acting through the calcitonin receptor-like receptor (zeige CALCRL ELISA Kits)/receptor activity-modifying protein receptor complexes
Our data suggest that IMD acutely augments cardiomyocyte contractile function through, at least in part, a protein kinase C (zeige PKC ELISA Kits)- and protein kinase A-dependent mechanism.
tissue adrenomedullin 2 intermedin content was positively correlated with the diastolic blood pressure and negatively correlated with pulse pressure
This gene encodes a protein which is a member of the calcitonin-related hormones. The encoded protein is involved in maintaining homeostasis in many tissues, acting via CRLR/RAMP receptor (calcitonin receptor-like receptor/receptor activity-modifying protein) complexes. Multiple alternatively spliced variants, encoding the same protein, have been identified.
, adrenomedullin 2 precusor