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anti-Human OAS3 Antikörper:
anti-Mouse (Murine) OAS3 Antikörper:
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Human Polyclonal OAS3 Primary Antibody für ELISA, WB - ABIN545736
Rebouillat, Hovnanian, Marié, Hovanessian: The 100-kDa 2',5'-oligoadenylate synthetase catalyzing preferentially the synthesis of dimeric pppA2'p5'A molecules is composed of three homologous domains. in The Journal of biological chemistry 1999
Show all 3 Pubmed References
Human Polyclonal OAS3 Primary Antibody für WB - ABIN390166
Ito, Shichijo, Tsuda, Ochi, Harashima, Saito, Itoh: Molecular basis of T cell-mediated recognition of pancreatic cancer cells. in Cancer research 2001
Show all 4 Pubmed References
Mitochondrial C11orf83 is a potent antiviral protein independent of interferon production; and knockdown of either OAS3 or RNase L impaired the antiviral capability of C11orf83.
Protein-coding rare variations on the OAS3 gene are associated with the coexistence of HBsAg and anti-HBs in patients with chronic hepatitis B infection in Chinese Han population.
The study findings suggest that the OAS3 rs1859330 G/A genetic polymorphism is associated with the severity of enterovirus 71 (EV71) infection, and that the A allele is a risk factor for the development of severe EV71 infection.
we characterized the functional consequences of the Neandertal haplotype in the transcriptional regulation of OAS genes at baseline and infected conditions. We found that cells from people with the Neandertal-like haplotype express lower levels of OAS3 upon infection, as well as distinct isoforms of OAS1 and OAS2
Here we report, to our knowledge, the first analysis of nuclear signal import in the pseudo enzymatic domain DI of human OAS3
OAS3 displayed a higher affinity for dsRNA in intact cells than either OAS1 or OAS2, consistent with its dominant role in RNase L activation.
Preliminary study suggests that OAS gene cluster and CD209 gene polymorphisms influence the risk of developing clinical symptoms in Chikungunya virus-infected patients.
By means of an allelic association study of a cohort of 740 patients with dengue, the authors found a protective effect of OAS3_R381 against shock.
Common variation at 12q24.13 (OAS3 intron) influences chronic lymphocytic leukemia risk.
The combined high affinity for double-stranded RNA and the capability to produce 2'-5'-linked oligoadenylates of sufficient length to activate RNase L suggests that OAS3 is a potent activator of RNase L.
The results suggest that OAS1-OAS3-OAS2 haplotypes are associated with differential susceptibility to clinical outcomes of dengue infection.
among the members of the OAS family, OAS1 p46 and OAS3 p100 mediate the RNase L-dependent antiviral activity against HCV
The data suggest a possible association between OAS2 and OAS3 single nucleotide polymorphisms and the outcome of tick-borne encephalitis virus infection in a Russian population.
OAS are interferon-inducible enzymes catalyzing 2'-5' instead of 3'-5' phosphodiester bond formation [review]
This gene encodes an enzyme included in the 2', 5' oligoadenylate synthase family. This enzyme is induced by interferons and catalyzes the 2', 5' oligomers of adenosine in order to bind and activate RNase L. This enzyme family plays a significant role in the inhibition of cellular protein synthesis and viral infection resistance.
2'-5' oligoadenylate synthetase 3
, 2'-5'-oligoadenylate synthase 3
, 2'-5'oligoadenylate synthetase 3
, (2-5')oligo(A) synthase 3
, (2-5')oligo(A) synthetase 3
, 2'-5'oligoadenylate synthetase p100
, 2-5A synthase 3
, 2-5A synthetase 3
, p100 OAS
, 2',5'-oligoadenylate synthetase-like 10
, 2'-5' oligoadenylate synthetase-like 10
, 2'-5'-oligoadenylate synthetase 3, 100kDa
, 2'-5'-oligoadenylate synthetase 3-like
, 2'-5'-oligoadenylate synthase 3-like
, 2'-5'-oligoadenylate synthetase 3