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these results indicate that CLDN8 functions as an androgen receptordownstream signal to facilitate the progression of prostate cancer
SOX9 (zeige SOX9 Proteine) may promote cell growth by repressing the expression of CLDN8.
Findings suggest a new mechanistic pathway in inflammatory bowel disease in which MiR (zeige MLXIP Proteine)-223 functions as a proinflammatory molecule targeting CLDN8 in the IL23 (zeige IL23A Proteine) pathway.
High Claudin 8 Contributes to Malignant Proliferation in Osteosarcoma.
the expression of claudin-5 (zeige CLDN5 Proteine) and claudin-9 (zeige CLDN9 Proteine) was down-regulated while the expression of claudin-8 was up-regulated in cervical carcinoma tissues compared with adjacent non-neoplastic tissues.
Human Cldn-8 and -14 were shown to convey Clostridium perfringens enterotoxin-mediated cytotoxicity at pathophysiologically relevant concentrations of this toxin, although ~2-to-10-fold less efficiently than Cldn-4 (zeige CLDN4 Proteine).
claudin-7 (zeige CLDN7 Proteine) and claudin-8 have potential use as immunohistochemical biomarkers in the differential diagnosis of chromophobe renal cell carcinoma (zeige MOK Proteine) and oncocytoma
Na(+) absorption is paralleled by claudin-8-mediated sealing of the paracellular barrier to prevent Na(+) back-leakage, supporting steep Na(+) gradients in distal colon.
the combination of CK7 (zeige KRT7 Proteine), S100A1 (zeige S100A1 Proteine) and claudin 8 immunohistochemistry can be useful for classifying tumours of overlapping histology as chromophobe renal cell carcinoma (zeige MOK Proteine) or renal oncocytomas.
CLDN8, clustered with CLDN17 (zeige CLDN17 Proteine) at human chromosome 21q22.11, is a four-transmembrane protein with WWCC motif, defined by W-X(17-22)-W-X(2)-C-X(8-10)-C.
We found that CLDN8 was expressed by both spermatogonia and a subset of Sertoli cells in the bovine testis.
KLHL3 (zeige KLHL3 Proteine) regulates paracellular chloride transport in the kidney by ubiquitination of claudin-8
Claudin-8 is expressed at the variety of epithelial tissues in inner ear including stria vascularis, Reissner's membrane, spiral limbus, vestibular sensory epithelia, and dark cell area.
data show that claudin-4 (zeige CLDN4 Proteine) interacts with claudin-8 and that their association is required for the anion-selective paracellular pathway in the collecting duct
claudin-8 was found to be expressed primarily at the tight junction along the entire aldosterone-sensitive distal nephron and in the late segments of the thin descending limbs of long-looped nephrons
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein plays important roles in the paracellular cation barrier of the distal renal tubule, and in the paracellular barrier to prevent sodium back-leakage in distal colon. Differential expression of this gene has been observed in colorectal carcinoma and renal cell tumors, and along with claudin-7, is an immunohistochemical marker for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma.