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Human Polyclonal CLDN3 Primary Antibody für WB - ABIN2801966
Katahira, Sugiyama, Inoue, Horiguchi, Matsuda, Sugimoto: Clostridium perfringens enterotoxin utilizes two structurally related membrane proteins as functional receptors in vivo. in The Journal of biological chemistry 1997
Show all 2 Pubmed References
Human Polyclonal CLDN3 Primary Antibody für ICC, IF - ABIN407632
He, Wei, Luo, Luo, Yang, Yu, Chen, Ma, Liang, Guo, Ye, Shi, Shen, Wang, Gong, He, Yang, Zhao, Song, Wei: Folate-linked lipoplexes for short hairpin RNA targeting claudin-3 delivery in ovarian cancer xenografts. in Journal of controlled release : official journal of the Controlled Release Society 2013
Data indicate that CDH11, ICAM1 (zeige ICAM1 Antikörper) and CLDN3 were overexpressed in tumors when compared to normal esophagus, normal gastric and non-dysplastic Barrett's.
Study provide first biochemically and clinically validated evidence to support a colorectal cancer-suppressive function of claudin-3 by serving as a conjoint rheostat for regulating Stat-3 (zeige STAT3 Antikörper) and Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper)-signaling.
These tumor samples express CD44 (zeige CD44 Antikörper) protein at low rather than high levels. There is no correlation between CLDN3 gene expression and protein expression in these CPTAC samples; hence, the claudin-low subtype defined by gene expression is not the same group of tumors as that defined by low expression of CLDN3 protein.
Increased expression of intestinal epithelial claudin-1 (zeige CLDN7 Antikörper) with downregulation of claudin-3 has been observed in intestinal inflammatory disorders.
Data show that the charge of Lys65 in claudin 1 (Cldn1 (zeige CLDN1 Antikörper)) and Glu158 in claudin 3 (Cldn3), and of Gln57 in claudin 5 (Cldn5 (zeige CLDN5 Antikörper)) are necessary for tight junction (TJ) strand formation.
Mislocalization claudin-3 to nucleus in colon cancer and mislocalization claudin-4 (zeige CLDN4 Antikörper) to nucleus in adenomas of the colon were detected for the first time. .
Reg (zeige EXTL3 Antikörper) I may play a role in the maintenance of mucosal barrier function by inducing tight junction proteins such as claudins 3 and 4.
Intracellular zinc has an essential role in the maintenance of the intestinal epithelial tight junction barrier through regulation of occludin (zeige OCLN Antikörper) proteolysis and claudin-3 transcription.
permeability barriers and affected cell morphology, proliferation, migration, AKT (zeige AKT1 Antikörper) signaling, and gene expression. When claudins are exogenously expressed, ARPE-19 more closely model native RPE (zeige RPE Antikörper).
localization of Cldn3, Cldn7 (zeige CLDN7 Antikörper) and Cldn10 (zeige CLDN10 Antikörper) proteins in the different compartments of murine endometrium up to day 8.5 of pregnancy (dpc) as well as in human endometrium and first trimester decidua
Reg (zeige KCNH2 Antikörper) I may play a role in the maintenance of mucosal barrier function by inducing tight junction proteins such as claudins 3 and 4.
claudin-3 and claudin-5 (zeige CLDN5 Antikörper) expression is increased by DHEAS (zeige SULT2A1 Antikörper) and tight junction formation is stimulated via a Gnalpha11-coupled receptor in Sertoli cells
Cldn3(-/-) mice are fertile and show no Sertoli cell tight junction structural defects, even during the stages of Sertoli cell tight junction remodeling when preleptotene spermatocytes translocate from the basal to the adluminal compartment.
Study highlights a profound role for the choroid plexus in the pathogenesis of multiple sclerosis, and implies that CLDN3 may be regarded as a crucial and novel determinant of blood-cerebrospinal fluid barrier integrity
Seminiferous stage-specific expression and localization of claudin 3 during spermatogenesis regulate the progression of meiosis by promoting germ cell migration across the blood-testis barrier.
Claudin-3 expression in uterine luminal epithelium is stimulated by progesterone and suppressed by heparin-binding epidermal growth factor-like growth factor (zeige HBEGF Antikörper).
Claudin-3 and Clara cell 10 kDa protein were identified as possible markers of early tobacco smoke-induced epithelial injury along alveolar ducts.
the results indicate that Grhl2 (zeige GRHL2 Antikörper) regulates epithelial morphogenesis through transcriptional up-regulation of Cldn3 and Cldn4 (zeige CLDN4 Antikörper), as well as of Rab25 (zeige RAB25 Antikörper), which increases the Cldn4 (zeige CLDN4 Antikörper) protein and its localization at TJs
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intronless gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares aa sequence similarity with a putative apoptosis-related protein found in rat.
, CPE-R 2
, CPE-receptor 2
, Clostridium perfringens enterotoxin receptor 2
, ventral prostate.1 protein homolog
, ventral prostate.1-like protein
, clostridium perfringens enterotoxin receptor 2
, ventral prostate.1 protein
, integral membrane protein claudin-3
, tight junction-associated protein