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expression of claudin-11 in cutaneous squamous cell carcinoma (cSCC (zeige CYP11A1 Proteine)) cells depended on the activity of p38delta MAPK (zeige MAPK1 Proteine); knock-down of claudin-11 enhanced cSCC (zeige CYP11A1 Proteine) cell invasion
Authors demonstrated that CLDN11 promoter hypermethylation is a frequent event in LSCC, and contributes to metastasis and progression of LSCC.
The expression of claudin-11, -23 was remarkably downregulated in gastric cancer.
Claudin-11 might represent the essential component of the blood-testis barrier in human.
the expression of miR (zeige MLXIP Proteine)-99b was inversely correlated with CLDN11 levels . These findings suggest that a high level of miR (zeige MLXIP Proteine)-99b expression is an independent prognostic factor and correlates with poor survival of patients with Hepatocellular carcinoma (HCC (zeige FAM126A Proteine))
CLDN11 is an epigenetic biomarker for malignancy in dysplastic nevus and melanoma.
these data suggest that cancer cells may induce CLDN11 overexpression and subsequent collective migration of peritumoral CAFs (zeige TBX1 Proteine) via TGF-beta (zeige TGFB1 Proteine) secretion.
The expression of claudin-11 was up regulated in gastric cancer tissue.
The spatial organization of claudin-11 and connexin-43 (zeige GJA1 Proteine) is altered in men with primary seminiferous tubule failure.
disorganization of claudin-11 expression in Sertoli cells might be one of the factors involved in the impairment of spermatogenesis.
Absence of claudin 11 in CNS myelin causes behavioral phenotypes and neurotransmitter imbalances in amygdala and auditory brainstem
Results show that the primary function of claudin-11 is to provide a barrier that impedes the diffusion of material through the intramyelinic compartment
The present study provides the first evidence that DPT (zeige DPT Proteine) may be a novel effector of cadmium chloride, highlighting the significant role of DPT (zeige DPT Proteine) in the regulation of claudin-11 expression
Local radiation-induced testicular oxidative stress can elevate the expression of claudin-11 in the testis tissue.
Peptide octamers to modify the course of relapsing experimental autoimmune encephalomyelitis in SJL mice immunized with an oliogodendrocyte-specific protein peptide (OSP 55-71).
Spermatogenesis in all founder mice harboring two copies of the endogenous Cldn11 gene was normal. The promoter/enhancer of the transgene, upstream of exon 1 of the Cldn11 gene, is sufficient to rescue azoospermia in Cldn11-null mice.
we identified Cldn1 (zeige CLDN1 Proteine), Cldn2 (zeige CLDN2 Proteine) and Cldn11 as genes that discriminate between diverse types of M2 macrophages
Cldn11(-/-) Sertoli cells exhibit a unique phenotype whereby loss of tight junction integrity results in loss of the epithelial phenotype.
claudin-11 has a role in forming tight junctions in stria vascularis required for hearing through generation of endocochlear potential
These data demonstrate that OSP/claudin-11 and PLP (zeige C3 Proteine) have essential structural functions in maintaining normal compact myelin and there is redundancy in their functions.
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified.
, claudin 11 (oligodendrocyte transmembrane protein)
, oligodendrocyte transmembrane protein
, oligodendrocyte-specific protein