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Human TRIM28 Protein expressed in Wheat germ - ABIN1323643
Fujimoto, Hamaguchi, Kaji, Matsushita, Ichimura, Kodera, Ishiguro, Ueda-Hayakawa, Asano, Ogawa, Fujikawa, Miyagi, Mabuchi, Hirose, Akimoto, Hatta, Tsutsui, Higashi, Igarashi, Seishima, Hasegawa et al.: Myositis-specific anti-155/140 autoantibodies target transcription intermediary factor 1 family proteins. ... in Arthritis and rheumatism 2012
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Our data demonstrate that the downregulation of TRIM28 gene expression reduced the ability of CSCs to self-renew that resulted in significant reduction of tumor growth. Loss of function of TRIM28 leads to dysregulation of cell cycle, cellular response to stress, cancer cell metabolism, and inhibition of oxidative phosphorylation.
Cell proliferation and apoptosis were almost completely abolished in the PAa cells cotreated with TRIM28 siRNA and etoposide following knockdown of E2F1 (zeige E2F1 Proteine). The results of our study demonstrated that the combination of TRIM28 siRNA and etoposide may be effective against nonsmall cell lung cancer (NSCLC)and has the potential of being a new therapeutic tool for future treatment.
The authors found that TRIM28 regulates alpha-Synuclein and tau nuclear levels and that its reduction rescues toxicity in animal models of tau- and alpha-Synuclein-mediated degeneration.
TRIM28 represses Endogenous retroviruses and consequently regulates the expression of neighboring genes.
it is primarily peroxide-induced p38 MAPK (zeige MAPK14 Proteine) that mediates Ser473 phosphorylation and activation of TIF1beta to enable more efficient DNA repair to assist in tumor cell survival against exogenous ROS (zeige ROS1 Proteine)
TRIM28 acts as a central factor in controlling endothelial inflammatory responses and angiogenic activities by retaining expression of TNFR-1 (zeige TNFRSF1A Proteine) and -2 and VEGF receptor 2 in endothelial cells
TRIM28 depletion repressed EZH2 (zeige EZH2 Proteine) recruitment to chromatin and expression of this gene set, in parallel with decreased CD44 (zeige CD44 Proteine)(hi)/CD24 (zeige CD24 Proteine)(lo) mammosphere formation.
These findings provide a unique context in which ataxia telangiectasia mutated (zeige ATM Proteine) proteins modify KAP1 (zeige CDKN3 Proteine) to regulate persistence of a herpesvirus in humans
our results suggest that KAP1 (zeige CDKN3 Proteine) Ser473 phosphorylation acts through MFN2 (zeige MFN2 Proteine) reduction to restrict mitochondrial hyperfusion, thereby contributing to cancer cell survival under conditions of sustained metabolic stress
OGA (zeige MGEA5 Proteine) is physically associated with the known RNA polymerase II (pol II) pausing/elongation factors SPT5 (zeige SUPT5H Proteine) and TRIM28-KAP1-TIF1beta, and a purified OGA (zeige MGEA5 Proteine)-SPT5 (zeige SUPT5H Proteine)-TIF1beta complex has elongation properties.
an important role for TRIM28 in cells resisting transition between somatic and pluripotent states, is reported.
Nuclear factors that bind to genomic regions with "Sertoli Cell Signature" could functionally interact with SOX9 (zeige SOX9 Proteine); TRIM28 is a new SOX9 (zeige SOX9 Proteine) partner in fetal testes.
TRIM28 safeguards germline-to-soma inheritance of epigenetic features at other genomic regions in an exquisitely stage-dependent manner.
Data suggest that TRIM28 regulates the expression of a subset of lncRNAs.
Zygotic TRIM28 is essential for genomic imprinting. Secondary imprints were hypomethylated in TRIM28 mutants.
Trim28(+/D9) mutant mice exhibit a bi-modal body-weight distribution, with isogenic animals randomly emerging as either normal or obese and few intermediates.
Data suggest that interaction between KAP1 and the KRAB A (zeige ZNF223 Proteine) box of zinc finger protein 809 (ZFP809) is critical in KAP1-dependent control of gene silencing for ZFP809 targets.
We find that NPCs use TRIM28-mediated histone modifications to dynamically regulate transcription and silencing of ERVs, which is in contrast to other somatic cell types using DNA methylation (zeige HELLS Proteine)
WTX stabilized chromatin binding by TRIM28 and contributed to transcriptional repression of repetitive sequences by TRIM28 in mouse embryonic stem cells.
KAP-1 may contribute to the repression of Ey and beta-major globin gene transcription through recruitment to the promoters of these two genes, mediated by the interaction of KAP-1 with either Zfp445 or MafK, respectively
The protein encoded by this gene mediates transcriptional control by interaction with the Kruppel-associated box repression domain found in many transcription factors. The protein localizes to the nucleus and is thought to associate with specific chromatin regions. The protein is a member of the tripartite motif family. This tripartite motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region.
E3 SUMO-protein ligase TRIM28
, KRAB-associated protein 1
, KRAB-interacting protein 1
, RING finger protein 96
, nuclear corepressor KAP-1
, transcription intermediary factor 1-beta
, transcriptional intermediary factor 1-beta
, tripartite motif-containing 28
, tripartite motif-containing protein 28
, transcription intermediary factor 1-beta-like
, KRAB-A-interacting protein
, transcriptional intermediary factor 1, beta
, tripartite motif protein 28
, TIF1beta transcription factor