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Für Ihre Validierungsdaten erstatten wir Ihnen den vollen Kaufpreis. Ich möchte dieses Produkt validierenRelevance Score | ABIN | Application | Konjugat | Host | Isotype | Epitope | Hersteller | Clonality | References | Details |
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24.137056 | ABIN6391361 | ELISA FACS IF WB | Goat | C-Term | Anmelden zum Anzeigen | Polyclonal | 0 | |||
23.408192 | ABIN4881046 | ELISA FACS IHC WB | Mouse | IgG1 | AA 26-161 | Anmelden zum Anzeigen | 5H4 | 0 | ||
23.408192 | ABIN1846141 | FACS IHC ELISA WB | Mouse | IgG1 | AA 26-161 | Anmelden zum Anzeigen | 0 | |||
14.066111 | ABIN4355158 | ELISA FACS IHC (p) WB | Mouse | IgG1 | Anmelden zum Anzeigen | 5H4 | 2 | |||
7 | ABIN3029025 | FACS ELISA WB | Rabbit | Ig Fraction | AA 395-450 | Anmelden zum Anzeigen | Polyclonal | 0 | ||
7 | ABIN3032695 | IHC ELISA WB | Rabbit | Ig Fraction | C-Term | Anmelden zum Anzeigen | Polyclonal | 0 | ||
7 | ABIN3032696 | ELISA WB | Rabbit | Ig Fraction | N-Term | Anmelden zum Anzeigen | Polyclonal | 0 | ||
7 | ABIN2426389 | IHC ELISA | Rabbit | IgG | Anmelden zum Anzeigen | Polyclonal | 0 | |||
7 | ABIN2431813 | IHC ELISA | Rabbit | IgG | Anmelden zum Anzeigen | Polyclonal | 0 | |||
4 | ABIN6265065 | ELISA WB | Rabbit | IgG | Anmelden zum Anzeigen | Polyclonal | 0 | |||
4 | ABIN2462795 | IHC ELISA WB | Rabbit | Anmelden zum Anzeigen | Polyclonal | 0 | ||||
4 | ABIN3032697 | ELISA WB | Rabbit | Ig Fraction | C-Term | Anmelden zum Anzeigen | Polyclonal | 0 | ||
1 | ABIN597698 | ELISA WB | Rat | IgG2a | Anmelden zum Anzeigen | 0 | ||||
1 | ABIN198021 | ELISA WB | Rat | IgG2a | AA 199-437 | Anmelden zum Anzeigen | 0 | |||
1 | ABIN2744343 | ELISA FACS WB | Rabbit | AA 397-431 | Anmelden zum Anzeigen | Polyclonal | 0 | |||
1 | ABIN2744344 | ELISA WB | Rabbit | AA 58-91 | Anmelden zum Anzeigen | Polyclonal | 0 | |||
1 | ABIN2744345 | ELISA WB | Rabbit | AA 368-401 | Anmelden zum Anzeigen | Polyclonal | 0 | |||
1 | ABIN2360154 | ELISA WB | Rat | IgG2a | AA 25-198, Lys122Arg-Mutante | Anmelden zum Anzeigen | 11C50 | 0 | ||
1 | ABIN2360155 | Neut IHC ELISA WB | Rat | IgG2a | AA 25-198 | Anmelden zum Anzeigen | 0 | |||
1 | ABIN1175087 | IHC ELISA WB | Biotin | Rabbit | IgG | Anmelden zum Anzeigen | Polyclonal | 0 |
General |
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Antigen | Sonic Hedgehog (SHH) Antikörper |
Epitop | AA 26-161 Alternativen |
Reaktivität | Human, Maus, Affe Alternativen |
Wirt | Maus Alternativen |
Klonalität (Klon) | |
Konjugat | Dieser Sonic Hedgehog Antikörper ist unkonjugiert Alternativen |
Applikation |
Flow Cytometry (FACS), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
Alternativen
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1 Publikation vorhanden |
Hersteller | Anmelden zum Anzeigen |
Produktdetails anti-Sonic Hedgehog AntikörperTarget Details Sonic Hedgehog Anwendungsinformationen Handhabung Referenzen für anti-Sonic Hedgehog Antikörper (ABIN969567) Bilder |
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Reinigung | Purified |
Immunogen | Purified recombinant fragment of human SHH (AA 26-161) expressed in E. Coli. |
Klon | 5H4 |
Isotyp | IgG1 |
Plasmids, Primers & others | |
Target Details Sonic HedgehogProduktdetails anti-Sonic Hedgehog Antikörper Anwendungsinformationen Handhabung Referenzen für anti-Sonic Hedgehog Antikörper (ABIN969567) Bilder zurück nach oben |
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Antigen | |
Andere Bezeichnung | SHH (SHH Antibody Abstract) |
Hintergrund | This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved, the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities. It is also thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities. Additionally, mutations in a long range enhancer located approximately 1 megabase upstream of this gene disrupt limb patterning and can result in preaxial polydactyly. |
Molekulargewicht | 49.6 kDa |
Gen-ID | 6469 |
HGNC | 6469 |
Pathways | Hedgehog Signalweg, Dopaminergic Neurogenesis, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development |
AnwendungsinformationenProduktdetails anti-Sonic Hedgehog Antikörper Target Details Sonic Hedgehog Handhabung Referenzen für anti-Sonic Hedgehog Antikörper (ABIN969567) Bilder zurück nach oben |
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Applikations-hinweise | ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, FCM: 1:200 - 1:400 |
Beschränkungen | Nur für Forschungszwecke einsetzbar |
HandhabungProduktdetails anti-Sonic Hedgehog Antikörper Target Details Sonic Hedgehog Anwendungsinformationen Referenzen für anti-Sonic Hedgehog Antikörper (ABIN969567) Bilder zurück nach oben |
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Format | Liquid |
Buffer | PBS with 0.05 % sodium azide |
Konservierungs-mittel | Sodium azide |
Vorsichtsmaßnahmen | This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only. |
Lagerung | 4 °C,-20 °C |
Informationen zur Lagerung | 4°C, -20°C for long term storage |
Referenzen für anti-Sonic Hedgehog Antikörper (ABIN969567)Produktdetails anti-Sonic Hedgehog Antikörper Target Details Sonic Hedgehog Anwendungsinformationen Handhabung Bilder zurück nach oben |
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Produkt verwendet in: |
Kameda, Nakamura, Tanaka, Yamasaki, Kubo, Tanaka, Onishi, Katano: "Oestrogen receptor-alpha contributes to the regulation of the hedgehog signalling pathway in ERalpha-positive gastric cancer." in: British journal of cancer, Vol. 102, Issue 4, pp. 738-47, 2010 |
BilderProduktdetails anti-Sonic Hedgehog Antikörper Target Details Sonic Hedgehog Anwendungsinformationen Handhabung Referenzen für anti-Sonic Hedgehog Antikörper (ABIN969567) zurück nach oben |
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Bilder des Herstellers |
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