anti-Human Sonic Hedgehog Antikörper für ELISA

Recommended Sonic Hedgehog Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Sonic Hedgehog (SHH) Antikörper
  • shh
  • SHH
  • 9530036O11Rik
  • Dsh
  • Hhg1
  • Hx
  • Hxl3
  • M100081
  • HHG1
  • HLP3
  • HPE3
  • MCOPCB5
  • SMMCI
  • TPT
  • TPTPS
  • Xhh
  • hedgehog
  • xshh
  • fc83d08
  • syu
  • vhh-1
  • vhh1
  • wu:fc83d08
  • sonic hedgehog
  • sonic hedgehog protein A
  • sonic hedgehog L homeolog
  • sonic hedgehog a
  • shh
  • SHH
  • Shh
  • shh.L
  • shha
Epitop
AA 181-281
17
15
9
7
5
5
5
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human
107
76
60
8
6
5
5
2
2
2
2
2
1
1
1
1
1
1
1
Wirt
Maus
94
40
10
1
Klonalität
Monoklonal
Konjugat
Dieser Sonic Hedgehog Antikörper ist unkonjugiert
7
3
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
ELISA
120
54
51
26
19
13
12
12
11
10
5
3
1
1
Optionen
Hersteller
Anmelden zum Anzeigen
Hersteller Produkt- Nr.
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Bilder

Produktnummer ABIN393243
$ 450.00
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
10.63904 ABIN4355158 ELISA FACS IHC (p) WB Mouse IgG1 Anmelden zum Anzeigen 5H4 2
10.63904 ABIN969567 FACS IHC ELISA WB Mouse IgG1 AA 26-161 Anmelden zum Anzeigen 5H4 1
10.63904 ABIN1846141 FACS IHC ELISA WB Mouse IgG1 AA 26-161 Anmelden zum Anzeigen 0
10.63904 ABIN520177 ELISA Mouse IgG2a kappa AA 181-280, partial Anmelden zum Anzeigen 1B11 0
1 ABIN1491290 ELISA FACS IHC IHC (p) Mouse IgG1 Anmelden zum Anzeigen 5H4 0
1 ABIN1804282 ELISA IHC IHC (p) WB Mouse IgG1 Anmelden zum Anzeigen 8G3 0
1 ABIN969395 ELISA WB Mouse IgG1 Anmelden zum Anzeigen 8G3 3
1 ABIN1585268 IHC ELISA WB Rabbit N-Term Anmelden zum Anzeigen Polyclonal 1
1 ABIN1501070 ELISA WB Mouse IgG1 Anmelden zum Anzeigen 8G3 0
1 ABIN967021 ELISA WB Mouse IgG1 Anmelden zum Anzeigen 8G3 3
1 ABIN4881046 ELISA FACS IHC WB Mouse IgG1 AA 26-161 Anmelden zum Anzeigen 5H4 0
1 ABIN2462795 IHC ELISA WB Rabbit Anmelden zum Anzeigen Polyclonal 0
1 ABIN1846140 ELISA WB Mouse IgG1 Anmelden zum Anzeigen 0
1 ABIN4244963 ELISA WB Mouse IgG1 Anmelden zum Anzeigen 8G3 0
1 ABIN1828878 ELISA Mouse IgG2a, kappa AA 181-280 Anmelden zum Anzeigen 1B11 0
1 ABIN562868 ELISA WB Mouse AA 181-280, partial Anmelden zum Anzeigen Polyclonal 0
1 ABIN5661987 ICC IHC (fro) IHC (p) ELISA WB Mouse IgG Anmelden zum Anzeigen 0
1 ABIN3029025 FACS ELISA WB Rabbit Ig Fraction AA 395-450 Anmelden zum Anzeigen Polyclonal 0
1 ABIN4355157 ELISA FACS IHC (p) WB Mouse IgG1 Anmelden zum Anzeigen 5H4 0
1 ABIN4880458 ELISA WB Mouse IgG1 Anmelden zum Anzeigen 8G3 0

General

Antigen Sonic Hedgehog (SHH) Antikörper
Epitop AA 181-281
(17), (15), (9), (7), (5), (5), (5), (3), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reaktivität Human
(107), (76), (60), (8), (6), (5), (5), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Wirt Maus
(94), (40), (10), (1)
Klonalität (Klon)
Monoklonal   ( )
Konjugat Dieser Sonic Hedgehog Antikörper ist unkonjugiert
(7), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation ELISA
(120), (54), (51), (26), (19), (13), (12), (12), (11), (10), (5), (3), (1), (1)
Pubmed 5 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-Sonic Hedgehog Antikörper

Target Details Sonic Hedgehog Anwendungsinformationen Handhabung Referenzen für anti-Sonic Hedgehog Antikörper (ABIN393243) Bilder
Spezifität SHH (NP_000184, 181 a.a. ~ 281 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Reinigung This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Immunogen SHH (NP_000184, 181 a.a. ~ 281 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Klon 1B11
Isotyp IgG2a kappa
Plasmids, Primers & others

Target Details Sonic Hedgehog

Produktdetails anti-Sonic Hedgehog Antikörper Anwendungsinformationen Handhabung Referenzen für anti-Sonic Hedgehog Antikörper (ABIN393243) Bilder zurück nach oben
Antigen
Andere Bezeichnung SHH (SHH Antibody Abstract)
Hintergrund Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molekulargewicht 49607 DA
Gen-ID 12406
NCBI Accession NP_000184
Pathways Hedgehog Signalweg, Dopaminergic Neurogenesis, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development

Anwendungsinformationen

Produktdetails anti-Sonic Hedgehog Antikörper Target Details Sonic Hedgehog Handhabung Referenzen für anti-Sonic Hedgehog Antikörper (ABIN393243) Bilder zurück nach oben
Applikations-hinweise ELISA ~~ 1ug/ml~3ng/ml
Kommentare

Background: This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved, the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities. It is also thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities. Additionally, mutations in a long range enhancer located approximately 1 megabase upstream of this gene disrupt limb patterning and can result in preaxial polydactyly.

Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-Sonic Hedgehog Antikörper Target Details Sonic Hedgehog Anwendungsinformationen Referenzen für anti-Sonic Hedgehog Antikörper (ABIN393243) Bilder zurück nach oben
Buffer PBS with 0.09% (w/v) sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Haltbarkeit 6 months

Referenzen für anti-Sonic Hedgehog Antikörper (ABIN393243)

Produktdetails anti-Sonic Hedgehog Antikörper Target Details Sonic Hedgehog Anwendungsinformationen Handhabung Bilder zurück nach oben
Allgemeine Veröffentlichungen

Jugessur, Shi, Gjessing, Lie, Wilcox, Weinberg, Christensen, Boyles, Daack-Hirsch, Nguyen, Christiansen, Lidral, Murray: "Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia." in: PLoS ONE, Vol. 5, Issue 7, pp. e11493, 2010

Choi, Witek, Yang, Omenetti, Syn, Moylan, Jung, Karaca, Teaberry, Pereira, Wang, Ren, Diehl: "Activation of Rac1 promotes hedgehog-mediated acquisition of the myofibroblastic phenotype in rat and human hepatic stellate cells." in: Hepatology (Baltimore, Md.), Vol. 52, Issue 1, pp. 278-90, 2010

Johnson, Yanek, Chen, Faraday, Larson, Tofler, Lin, Kraja, Province, Yang, Becker, ODonnell, Becker: "Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists." in: Nature genetics, Vol. 42, Issue 7, pp. 608-13, 2010

Lauth, Bergström, Shimokawa, Tostar, Jin, Fendrich, Guerra, Barbacid, Toftgård: "DYRK1B-dependent autocrine-to-paracrine shift of Hedgehog signaling by mutant RAS." in: Nature structural & molecular biology, Vol. 17, Issue 6, pp. 718-25, 2010

Hatton, Villavicencio, Pritchard, LeBlanc, Hansen, Ulrich, Ditzler, Pullar, Stroud, Olson: "Notch signaling is not essential in sonic hedgehog-activated medulloblastoma." in: Oncogene, Vol. 29, Issue 26, pp. 3865-72, 2010

Bilder

Produktdetails anti-Sonic Hedgehog Antikörper Target Details Sonic Hedgehog Anwendungsinformationen Handhabung Referenzen für anti-Sonic Hedgehog Antikörper (ABIN393243) zurück nach oben
Bilder des Herstellers
ELISA image for anti-Sonic Hedgehog (SHH) (AA 181-281) antibody (ABIN393243) Detection limit for recombinant GST tagged SHH is approximately 0.3 ng/mL as a captur...