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anti-Human GLI2 Antikörper:
anti-Rat (Rattus) GLI2 Antikörper:
anti-Mouse (Murine) GLI2 Antikörper:
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Human Polyclonal GLI2 Primary Antibody für IHC, WB - ABIN2777474
Ikram, Neill, Regl, Eichberger, Frischauf, Aberger, Quinn, Philpott: GLI2 is expressed in normal human epidermis and BCC and induces GLI1 expression by binding to its promoter. in The Journal of investigative dermatology 2004
Show all 24 Pubmed References
Human Polyclonal GLI2 Primary Antibody für ChIP, ELISA - ABIN269891
Won, Kim, Lim, Sung, Kim, Park, Lee, Choi: Autophagy is related to the hedgehog signaling pathway in human gastric adenocarcinoma: prognostic significance of Beclin-1 and Gli2 expression in human gastric adenocarcinoma. in Pathology, research and practice 2015
Show all 3 Pubmed References
Human Polyclonal GLI2 Primary Antibody für ELISA - ABIN547626
Haycraft, Banizs, Aydin-Son, Zhang, Michaud, Yoder: Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function. in PLoS genetics 2005
Human Polyclonal GLI2 Primary Antibody für IHC, WB - ABIN5516755
Enzenhofer, Parzefall, Haymerle, Schneider, Kadletz, Heiduschka, Pammer, Oberndorfer, Wrba, Loader, Grasl, Perisanidis, Erovic: Impact of Sonic Hedgehog Pathway Expression on Outcome in HPV Negative Head and Neck Carcinoma Patients after Surgery and Adjuvant Radiotherapy. in PLoS ONE 2016
Human Polyclonal GLI2 Primary Antibody für ICC, IF - ABIN4314278
Martinez, Kobayashi, Krishnan, Webber, Christie, Guo, Singh, Zochodne: Intrinsic facilitation of adult peripheral nerve regeneration by the Sonic hedgehog morphogen. in Experimental neurology 2015
Human Polyclonal GLI2 Primary Antibody für IHC, ELISA - ABIN129627
Roessler, Ermilov, Grange, Wang, Grachtchouk, Dlugosz, Muenke: A previously unidentified amino-terminal domain regulates transcriptional activity of wild-type and disease-associated human GLI2. in Human molecular genetics 2005
Importantly, high expression levels of HIF-1alpha (zeige HIF1A Antikörper)/TGF-beta2 (zeige TGFB2 Antikörper)/GLI2 correlated robustly with the patient relapse following chemotherapy, highlighting a potential biomarker and therapeutic target for chemoresistance in colorectal cancer.
Study found increased expression of GLI2 in osteosarcoma tissues and cell lines and determined that GLI2 is a target of miR (zeige MLXIP Antikörper)-141-3p.
In conclusion, our data suggest that overexpression of the Hedgehog (zeige SHH Antikörper) components SHH (zeige SHH Antikörper), GLI2 and FOXA2 (zeige FOXA2 Antikörper) might be used as markers of an aggressive hemangioma.
High GLI2 or PDGFRB expression is associated with unfavorable survival in GC patients. GLI2 can induce PDGFRB expression in GC cells via directly binding to its promoter. In addition, the GLI2-PDGFRB axis might be an important signaling pathway modulating CSC properties of GC cells.
Study report that compromised CSL (zeige CSHL1 Antikörper) function depends on GLI (zeige GLI1 Antikörper) activation for conversion of human dermal fibroblasts into CAFs (zeige TBX1 Antikörper), separately from cellular senescence. Decreased CSL (zeige CSHL1 Antikörper) upregulates the expression of the ULK3 (zeige ULK3 Antikörper) kinase, which binds and activates GLI2.
The authors found that hepatitis C virus derived from hepatitis C patients infected and directly induced the trans-differentiation of human primary fibroblasts into myofibroblasts, promoting fibrogenesis. This effect correlated with the activation of GLI2, one of the targets of Hedgehog (zeige SHH Antikörper) signaling pathway previously reported to be involved in myofibroblast generation.
role of GLI2-ABCG2 signaling axis for 5Fu resistance in gastric cancer
This study showed associations of anorectal malformations with rs3738880 in GLI2 and with previous miscarriages.
High GLI2 expression is associated with hepatocellular carcinoma.
Hedgehog (zeige SHH Antikörper) pathway dysregulation contributes to the pathogenesis of human gastrointestinal stromal tumors via GLI (zeige GLI1 Antikörper)-mediated activation of KIT expression.
Data indicate that the expression levels of transcription factors Gli1 (zeige GLI1 Antikörper) and Gli2 in muscle were the lowest of the 13 tissues.
The 12 SNPs of GLI2 encompassing exon 4 to exon 8 showed strong association with in the anorectal atresia in pigs.
Gli2 upregulation changed the cytokine expression profile in mouse pancreatic acinar cells, mainly decreasing the pro-inflammatory cytokines interleukin (IL)-6 (zeige IL6 Antikörper), interferon-gamma (zeige IFNG Antikörper), and FasL (zeige FASL Antikörper).
Here by inducing expression of constitutively active Smoothened (SmoM2) or Gli2 (DeltaNGli2) in the adipocyte lineage of postnatal mice, the authors show that targeted activation of Hedgehog (zeige SHH Antikörper) signaling suppresses high-fat-diet-induced obesity and improves whole-body glucose tolerance and insulin (zeige INS Antikörper) sensitivity.
mice with single-allele Gli2 mutations exhibit increased penetrance and severity of Holoprosencephaly in response to low-dose teratogen exposure.
Gli2, the major Hedgehog pathway transcriptional effector, acts within mouse mammary stromal cells to direct a hormone-responsive niche signaling program by activating expression of factors that regulate epithelial stem cells as well as receptors for the mammatrophic hormones estrogen and growth hormone.
Gli2 and Gli3 (zeige GLI3 Antikörper) are dephosphorylated and activated in cilia and that impaired Gli2 and Gli3 (zeige GLI3 Antikörper) processing in Ta3 (zeige HSP90B1 Antikörper) mutant is at least in part due to a decrease in Gli2 and Gli3 (zeige GLI3 Antikörper) phosphorylation.
studies identify a novel molecular mechanism of regulation of CD40L (zeige CD40LG Antikörper) by the transcription factor GLI2 in the tumor microenvironment downstream of CCR3 (zeige CCR3 Antikörper) signaling
Sufu (zeige SUFUH Antikörper) is upregulated in active Shh (zeige SHH Antikörper) responding tissues and accompanies Gli (zeige GLI1 Antikörper) activators translocating into and Gli (zeige GLI1 Antikörper) repressors out of the nucleus.
Gli2+/-;Gli3Delta699/+ mice can serve as a genetic mouse model for common DSD (zeige FADS1 Antikörper).
Despite increased production of full-length GLI2 and GLI3 (zeige GLI3 Antikörper) isoforms, previously identified GLI (zeige GLI1 Antikörper) targets important for mandibular and glossal development (Foxf1 (zeige FOXF1 Antikörper), Foxf2 (zeige FOXF2 Antikörper), Foxd1 (zeige FOXD1 Antikörper) and Foxd2 (zeige FOXD2 Antikörper)) were transcriptionally downregulated in Kif3a (zeige KIF3A Antikörper)(f/f);Wnt1 (zeige WNT1 Antikörper)-Cre embryos.
Gli1 and Gli2 exhibited different functions in the regulation of p63 expression or proliferation of p63(+) cells in Kras-AR driven tumors.
This gene encodes a protein which belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors which bind DNA through zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. The encoded protein is associated with several phenotypes- Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B.
GLI-Kruppel family member GLI2
, glioma-associated oncogene family zinc finger 2
, oncogene GLI2
, tax helper protein 1
, tax helper protein 2
, tax-responsive element-2 holding protein
, tax-responsive element-25-bp sequence binding protein
, zinc finger protein GLI2
, Zn finger transcription factor
, zinc finger protein GLI3
, Tax helper protein