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anti-Human GLI2 Antikörper:
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Human Polyclonal GLI2 Primary Antibody für IHC, WB - ABIN2777474
Ikram, Neill, Regl, Eichberger, Frischauf, Aberger, Quinn, Philpott: GLI2 is expressed in normal human epidermis and BCC and induces GLI1 expression by binding to its promoter. in The Journal of investigative dermatology 2004
Show all 24 Pubmed References
Human Polyclonal GLI2 Primary Antibody für ChIP, ELISA - ABIN269891
Won, Kim, Lim, Sung, Kim, Park, Lee, Choi: Autophagy is related to the hedgehog signaling pathway in human gastric adenocarcinoma: prognostic significance of Beclin-1 and Gli2 expression in human gastric adenocarcinoma. in Pathology, research and practice 2015
Show all 4 Pubmed References
Mouse (Murine) Polyclonal GLI2 Primary Antibody für IHC (fro), IHC (p) - ABIN538409
McDermott, Gustafsson, Elsam, Hui, Emerson, Borycki: Gli2 and Gli3 have redundant and context-dependent function in skeletal muscle formation. in Development (Cambridge, England) 2004
Show all 3 Pubmed References
Human Polyclonal GLI2 Primary Antibody für IHC, ELISA - ABIN129627
Roessler, Ermilov, Grange, Wang, Grachtchouk, Dlugosz, Muenke: A previously unidentified amino-terminal domain regulates transcriptional activity of wild-type and disease-associated human GLI2. in Human molecular genetics 2005
Human Polyclonal GLI2 Primary Antibody für ELISA - ABIN547626
Haycraft, Banizs, Aydin-Son, Zhang, Michaud, Yoder: Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function. in PLoS genetics 2005
Human Polyclonal GLI2 Primary Antibody für WB - ABIN3042988
Xiang, Jiang, Guo, Gong, Yang, Wu, Huang, Cheng, Xu: Hedgehog pathway inhibitor-4 suppresses malignant properties of chondrosarcoma cells by disturbing tumor ciliogenesis. in Oncology reports 2014
Human Polyclonal GLI2 Primary Antibody für ICC, IF - ABIN4314278
Martinez, Kobayashi, Krishnan, Webber, Christie, Guo, Singh, Zochodne: Intrinsic facilitation of adult peripheral nerve regeneration by the Sonic hedgehog morphogen. in Experimental neurology 2015
Human Polyclonal GLI2 Primary Antibody für IHC, WB - ABIN5516755
Enzenhofer, Parzefall, Haymerle, Schneider, Kadletz, Heiduschka, Pammer, Oberndorfer, Wrba, Loader, Grasl, Perisanidis, Erovic: Impact of Sonic Hedgehog Pathway Expression on Outcome in HPV Negative Head and Neck Carcinoma Patients after Surgery and Adjuvant Radiotherapy. in PLoS ONE 2016
Usage of alternative transcription initiation/termination sites generates N- and C-terminally truncated GLI2. High expression of N- and C-terminally truncated GLI2 is coupled to melanoma invasion. RNA processing of GLI2 is TGFbeta-dependent in melanoma
Authors found that ARHGEF16 mRNA level was upregulated in U87 cells overexpressing GLI2A relative to control cells. GLI2 binds to the ARHGEF16 promoter and activates gene transcription. Glioma cells U87 and U118 overexpressing ARHGEF16 showed enhanced migration and proliferation.
Importantly, high expression levels of HIF-1alpha/TGF-beta2/GLI2 correlated robustly with the patient relapse following chemotherapy, highlighting a potential biomarker and therapeutic target for chemoresistance in colorectal cancer.
Study found increased expression of GLI2 in osteosarcoma tissues and cell lines and determined that GLI2 is a target of miR-141-3p.
In conclusion, our data suggest that overexpression of the Hedgehog components SHH, GLI2 and FOXA2 might be used as markers of an aggressive hemangioma.
High GLI2 or PDGFRB expression is associated with unfavorable survival in GC patients. GLI2 can induce PDGFRB expression in GC cells via directly binding to its promoter. In addition, the GLI2-PDGFRB axis might be an important signaling pathway modulating CSC properties of GC cells.
Study report that compromised CSL function depends on GLI activation for conversion of human dermal fibroblasts into CAFs, separately from cellular senescence. Decreased CSL upregulates the expression of the ULK3 kinase, which binds and activates GLI2.
The authors found that hepatitis C virus derived from hepatitis C patients infected and directly induced the trans-differentiation of human primary fibroblasts into myofibroblasts, promoting fibrogenesis. This effect correlated with the activation of GLI2, one of the targets of Hedgehog signaling pathway previously reported to be involved in myofibroblast generation.
role of GLI2-ABCG2 signaling axis for 5Fu resistance in gastric cancer
This study showed associations of anorectal malformations with rs3738880 in GLI2 and with previous miscarriages.
High GLI2 expression is associated with hepatocellular carcinoma.
Hedgehog pathway dysregulation contributes to the pathogenesis of human gastrointestinal stromal tumors via GLI-mediated activation of KIT expression.
our findings demonstrate that multiple signaling pathways converge on Gli2 to mediate PTHrP expression and bony invasion, highlighting Gli2 as a therapeutic target to prevent bony invasion in OSCC.
the effect gene of the Shh pathway, gli1, was found to have a reduced level of expression along with a decreased expression of gli2.
High Gli2 expression is associated with non-small cell lung cancer.
GLI2 is a dosage-sensitive gene that may be responsible for the agenesis of corpus callosum observed in the proband.
This inhibitory effect on cell growth was partially rescued by exogenous KRT17 expression. In the KRT17-positive regions in OSCCs, GLI-1 or GLI-2 was frequently detected, and the number of cells with cleaved caspase-3 positive was decreased. CONCLUSIONS: KRT17 promotes tumor cell growth, at least partially, through its anti-apoptotic effect as a result of the KRT17 overexpression by GLIs in OSCC
Data suggest that Nrp1 (neuropilin-1) regulates Hedgehog signaling specifically at the level of activation of GLI2 transcriptional activator function; Nrp1 localization to primary cilium does not correlate with Hedgehog signal promotion. These studies were conducted in various cell types.
studies identify a novel molecular mechanism of regulation of CD40L by the transcription factor GLI2 in the tumor microenvironment downstream of CCR3 signaling
the data suggest that CCRK positively regulates the kinetics by which ciliary proteins such as Smoothened and Gli2 are imported into the cilium, and that the efficiency of ciliary recruitment allows for potent responses to Hedgehog signaling over long time periods.
Data indicate that the expression levels of transcription factors Gli1 and Gli2 in muscle were the lowest of the 13 tissues.
The 12 SNPs of GLI2 encompassing exon 4 to exon 8 showed strong association with in the anorectal atresia in pigs.
Gli2 upregulation changed the cytokine expression profile in mouse pancreatic acinar cells, mainly decreasing the pro-inflammatory cytokines interleukin (IL)-6, interferon-gamma, and FasL.
Here by inducing expression of constitutively active Smoothened (SmoM2) or Gli2 (DeltaNGli2) in the adipocyte lineage of postnatal mice, the authors show that targeted activation of Hedgehog signaling suppresses high-fat-diet-induced obesity and improves whole-body glucose tolerance and insulin sensitivity.
mice with single-allele Gli2 mutations exhibit increased penetrance and severity of Holoprosencephaly in response to low-dose teratogen exposure.
Gli2, the major Hedgehog pathway transcriptional effector, acts within mouse mammary stromal cells to direct a hormone-responsive niche signaling program by activating expression of factors that regulate epithelial stem cells as well as receptors for the mammatrophic hormones estrogen and growth hormone.
Gli2 and Gli3 are dephosphorylated and activated in cilia and that impaired Gli2 and Gli3 processing in Ta3 mutant is at least in part due to a decrease in Gli2 and Gli3 phosphorylation.
Sufu is upregulated in active Shh responding tissues and accompanies Gli activators translocating into and Gli repressors out of the nucleus.
Gli2+/-;Gli3Delta699/+ mice can serve as a genetic mouse model for common DSD.
Despite increased production of full-length GLI2 and GLI3 isoforms, previously identified GLI targets important for mandibular and glossal development (Foxf1, Foxf2, Foxd1 and Foxd2) were transcriptionally downregulated in Kif3a(f/f);Wnt1-Cre embryos.
Gli1 and Gli2 exhibited different functions in the regulation of p63 expression or proliferation of p63(+) cells in Kras-AR driven tumors.
Our findings suggest that ciliopathic facial phenotypes are generated via loss of both GLI3R and GLI2R and that this pathology occurs via a de-repression mechanism. Furthermore, these studies suggest a novel role for GLI2R in craniofacial development.
the GLI2 protein level could serve as a feasible marker of ligand-dependent hedgehog activation in pancreatic neoplasms.
Study suggested that loss of Gli2 mRNA mediated the anterior-restricted defect in conditional Dicer knockdown mice and showed that miR-106b positively regulated Gli2 mRNA expression
Sufu deletion early in embryogenesis resulted in unstable Gli2 and Gli3 activity, leading to the ectopic activation of Shh signaling.
the three GLI factors(GLI1, GLI2, and GLI3) in mature hepatocytes form an interactive transcriptional network that is involved in the control of target genes associated with metabolic zonation as well as with lipid and drug metabolism
Gli2 protein expression is downregulated during neural tube patterning, regulating Shh signaling. Shh-induced upregulation of Gli2 transcription prevents Gli activity levels from adapting in a different cell type.
Expression of Gli2A in T-cells altered gene expression profiles.
GLI2 binds to the IL-6Ralpha promoter and regulates its activity as well as the expression of this receptor.
The results uncover that both Shh/Gli2 and Shh/Gli3 signals are required for proper development of murine placentas and are possibly essential for pregnant maintenance.
While darinaparsin ameliorated fibrosis in WT and Gli1-KO mice, it was not effective in conditional Gli2-KO mice, supporting GLI2 as a direct darinaparsin target.
This gene encodes a protein which belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors which bind DNA through zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. The encoded protein is associated with several phenotypes- Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B.
GLI-Kruppel family member GLI2
, glioma-associated oncogene family zinc finger 2
, oncogene GLI2
, tax helper protein 1
, tax helper protein 2
, tax-responsive element-2 holding protein
, tax-responsive element-25-bp sequence binding protein
, zinc finger protein GLI2
, Zn finger transcription factor
, zinc finger protein GLI3
, Tax helper protein