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Human ITIH1 Protein expressed in Wheat germ - ABIN1308229
Gu, Duce, Valova, Wong, Bush, Petrou, Wiley: P2X7 receptor-mediated scavenger activity of mononuclear phagocytes toward non-opsonized particles and apoptotic cells is inhibited by serum glycoproteins but remains active in cerebrospinal fluid. in The Journal of biological chemistry 2012
PTX3 directly interacts with inter-alpha-trypsin inhibitor and has a role in hyaluronan organization and cumulus oophorus expansion
In a sepsis model inter-alpha-trypsin inhibitor inhibits complement activation through the classical and alternative pathways, inhibits complement-dependent phagocytosis in vitro, and reduces complement-dependent lung injury in vivo.
Furthermore, thrombin treatment of the inflammatory matrix leads to dissolution of HC-HA cable structures and abolishes leukocyte adhesion. These data establish a novel mechanism whereby thrombin cleavage of HC1 regulates the adhesive properties of an inflammatory HA matrix.
Data suggest that Mg2+ or Mn2+ (but not Ca2+) induce a conformational change in inter-alpha-inhibitor (ITIH1 and ITIH2) and a bikunin/chondroitin sulfate-dependent increase in thermodynamic stability; bikunin binds adjacent to the two heavy chains.
The results of this study revealed that the shared genetic risk factors of both schizophrenia and major depressive disorder exist in ITIH family genes in the Han Chinese population.
Data indicate that TSG-6-mediated cross-linking of hyaluronan (HA) films is impaired in the presence of inter-alpha-inhibitor (IalphaI) and that this effect suppresses the TSG-6-mediated enhancement of HA binding to CD44-positive cells.
Human inter-alpha-inhibitor is a substrate for factor XIIIa and tissue transglutaminase.
Transfection into H460M Human large cell lung carcinoma line decreased tumor metastasis in nude mice
The first systematic analysis on the differential expression of ITIH genes in human cancer, showing frequent downregulation that may be associated with initiation and/or progression of these malignancies.
The protein encoded by this gene is the heavy chain of a serine protease inhibitor that may serve to carry hyaluronan in plasma. This gene is part of a cluster of similar genes on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene.
ITI heavy chain H1
, inter-alpha (globulin) inhibitor, H1 polypeptide
, inter-alpha-inhibitor heavy chain 1
, inter-alpha-trypsin inhibitor heavy chain H1
, inter-alpha (globulin) inhibitor H1
, inter-alpha-trypsin inhibitor complex component III
, serum-derived hyaluronan-associated protein
, inter-alpha-trypsin inhibitor heavy-chain H1