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the relative expression of hyalurosome (CD44, HAS3, HB-EGF) genes was found to be reduced in patients prior to topical treatment and to be notably increased following treatment.
mutations of the HYAL3 gene are rare in Chinese lung squamous cell carcinoma patients and might contribute to lymph node metastasis
polymorphisms in HYAL3 are potentially involved in glaucomatous neurodegeneration.
Nodular basal cell carcinoma is associated with increased levels of hyaluronic acid concomitant with upregulation of gene expression of HAS3, HYAL3 and RHAMM, when compared with normal adjacent skin.
Overexpression of HYAL3 is associated with colorectal cancer.
Hyal3 null sperm showed delayed cumulus penetration and reduced acrosomal exocytosis.
Characterization of the murine hyaluronidase gene region reveals complex organization and cotranscription of Hyal1 with downstream genes, Fus2 and Hyal3.
Alternative mRNA splicing controls cellular expression of enzymatically active hyaluronidase.
Down-regulation of HYAL3 is associated with small cell lung cancer and glioma
Data show that Hyal-1, but not Hyal-3,is an ovarian regulator factor for follicle development, and show an interrelationship between this enzyme and the follistatin/activin/Smad3 pathway.
Hyal3 may contribute to hyaluronan metabolism by augmenting the activity of Hyal1.
Hyaluronidase induces ovarian granulosa cell apoptosis and is involved in follicular atresia.
HYAL3 does not play a major role in constitutive hyaluronan degradation
the porcine hyaluronidase cluster consisting of genes HYAL1, HYAL2 and HYAL3 was characterized
This gene encodes a member of the hyaluronidase family. Hyaluronidases are endoglycosidase enzymes that degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. The regulated turnover of hyaluronan plays a critical role in many biological processes including cell proliferation, migration and differentiation. The encoded protein may also play an important role in sperm function. This gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression, and the expression of specific transcript variants may be indicative of tumor status. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and some isoforms may lack hyaluronidase activity. This gene overlaps and is on the same strand as N-acetyltransferase 6 (GCN5-related), and some transcripts of each gene share a portion of the first exon.
, hyaluronoglucosaminidase 1
, hyaluronoglucosaminidase 3
, hyaluronidase 3
, lung carcinoma protein 3