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The T allele of GPC4 may represent a risk factor for Epstein-Barr virus-associated gastric carcinoma.
According to behavioral studies, downregulation of Gpc4 by Gpc4 siRNA decreased spontaneous seizure frequency, while upregulation of Gpc4 by recombinant Gpc4 overexpression led to a converse result. These findings support the hypothesis that increased expression of Gpc4 in the brain is associated with epileptic seizures.
Data suggest gender difference in circulating GPC4 levels in nonalcoholic fatty liver disease; GPC4 levels in women appear to correlate with cardiometabolic risk factors (adiposity/body fat distribution, insulin (zeige INS Proteine) resistance, and arterial stiffness).
new function of miR (zeige MLXIP Proteine)-125a by targeting gene glypican-4 in cell growth process
Findings establish that Gpc4 acts at the interface of extrinsic and intrinsic signal regulation to fine tune stem cell fate.
Glypican 4 induces release of neuronal pentraxin 1 (zeige NPX1 Proteine) from presynaptic terminals.
data identify glypicans as a family of novel astrocyte-derived molecules that are necessary and sufficient to promote glutamate (zeige GRIN1 Proteine) receptor clustering and receptivity and to induce the formation of postsynaptically functioning CNS synapses
complex pattern of glypican-4 mRNA localization at embryonic days 7-10.5, including sites in the anterior forebrain neuroepithelium, branchial arches, optic and otic vesicles, limb buds and somites
The results suggest that Gpc4 is crucial for generating the environment required for efficient migration of endodermal cells, uncovering a novel function of Gpc4 during development.
the chaperon Wls (zeige WLS Proteine) and its ligands Wnt9a (zeige WNT9A Proteine) and Wnt5b (zeige WNT5B Proteine) are expressed in the ectoderm, whereas juxtaposed chondrocytes express Frzb (zeige FRZB Proteine) and Gpc4.
A mutation in glypican4 leads to severe lateral line primordium migration defects. Glypican4 regulates the feedback loop between Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine)/Fgf signaling in the primordium redundantly with other HSPGs. A mutation in glypican4 affects primordium migration non cell-autonomously
disruption of wls (zeige WLS Proteine) resulted in a significant loss of craniofacial bone, whereas lack of gpc4, wnt5b (zeige WNT5B Proteine) and wnt9a (zeige WNT9A Proteine) resulted in severely delayed endochondral ossification.
novel mechanism for Wnt5b (zeige WNT5B Proteine) and Gpc4 regulation of chondrocyte behavior that is independent of the core Wnt (zeige WNT2 Proteine)/PCP (zeige PRCP Proteine) molecules and differs from their collaborative action of controlling cell movements during gastrulation
glypican4 mutants do not have decreased proteolysis of ECM substrates, but instead have increased cell surface cadherin protein expression and increased intercellular adhesion.
These findings implicate Gpc4 in the regulation of zebrafish cartilage and bone morphogenesis.
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The GPC4 gene is adjacent to the 3' end of GPC3 and may also play a role in Simpson-Golabi-Behmel syndrome.
, glypican 4
, dJ900E8.1 (glypican 4)
, glypican proteoglycan 4