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Für Ihre Validierungsdaten erstatten wir Ihnen den vollen Kaufpreis. Ich möchte dieses Produkt validierenRelevance Score | ABIN | Application | Konjugat | Host | Isotype | Epitope | Hersteller | Clonality | References | Details |
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3.2908103 | ABIN2785640 | WB | Rabbit | Middle Region | Anmelden zum Anzeigen | Polyclonal | 1 | |||
1 | ABIN477635 | WB | Rabbit | IgG | AA 143-192 | Anmelden zum Anzeigen | Polyclonal | 0 |
General |
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Antigen | Fucosidase, alpha-L- 1, Tissue (FUCA1) Antikörper |
Epitop | N-Term Alternativen |
Reaktivität | Rind (Kuh), Hund, Meerschweinchen, Pferd, Human, Maus, Schwein, Kaninchen, Ratte (Rattus) Alternativen |
Wirt | Kaninchen Alternativen |
Klonalität | |
Konjugat | Unkonjugiert Alternativen |
Applikation |
Western Blotting (WB)
Alternativen
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1 Publikation vorhanden |
Hersteller | Anmelden zum Anzeigen |
ProduktdetailsAntigendetails Anwendungsinformationen Handhabung Referenzen Bilder |
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Blocking Peptide | Zu diesem Produkt passt das Blocking Peptide ABIN977137. |
Sequenz | PSPVSWNWNS KDVGPHRDLV GELGTALRKR NIRYGLYHSL LEWFHPLYLL |
Homologie | Cow: 100%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 79%, Rat: 100% |
Produktmerkmale | This is a rabbit polyclonal antibody against FUCA1. It was validated on Western Blot using a cell lysate as a positive control. |
Reinigung | Affinity Purified |
Immunogen | The immunogen is a synthetic peptide directed towards the N terminal region of human FUCA1 |
AntigendetailsProduktdetails Anwendungsinformationen Handhabung Referenzen Bilder zurück nach oben |
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Antigen | |
Andere Bezeichnung | FUCA1 (FUCA1 Antibody Abstract) |
Hintergrund |
Alpha-L-fucosidase (EC 3.2.1.51) is a lysosomal enzyme involved in the degradation of fucose-containing glycoproteins and glycolipids. At least 2 separate polymorphic alpha-L-fucosidases are recognized in man: that in tissues, FUCA1, which is deficient in fucosidosis, and that in plasma, FUCA2. Fucosidosis is an autosomal recessive lysosomal storage disease caused by defective alpha-L-fucosidase with accumulation of fucose in the tissues. Different phenotypes include clinical features such as neurologic deterioration, growth retardation, visceromegaly, and seizures in a severe early form, coarse facial features, angiokeratoma corporis diffusum, spasticity and delayed psychomotor development in a longer surviving form, and an unusual spondylometaphyseoepiphyseal dysplasia in yet another form.[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. Alias Symbols: FUCA Protein Interaction Partner: PAXIP1, BARD1, APP, CUL3, VAV2, USP21, MARK2, Protein Size: 466 |
Molekulargewicht | 54 kDa |
Gen-ID | 2517 |
NCBI Accession | NM_000147, NP_000138 |
UniProt | P04066 |
Pathways | Glycosaminoglycan Metabolic Process |
AnwendungsinformationenProduktdetails Antigendetails Handhabung Referenzen Bilder zurück nach oben |
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Applikationshinweise | Optimal working dilutions should be determined experimentally by the investigator. |
Kommentare |
Antigen size: 466 AA |
Beschränkungen | Nur für Forschungszwecke einsetzbar |
HandhabungProduktdetails Antigendetails Anwendungsinformationen Referenzen Bilder zurück nach oben |
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Format | Liquid |
Konzentration | Lot specific |
Buffer | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose. |
Konservierungsmittel | Sodium azide |
Vorsichtsmaßnahmen | This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only. |
Handhabung | Avoid repeated freeze-thaw cycles. |
Lagerung | -20 °C |
Informationen zur Lagerung | For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles. |
ReferenzenProduktdetails Antigendetails Anwendungsinformationen Handhabung Bilder zurück nach oben |
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Allgemeine Veröffentlichungen |
Venditti, Donigan, Bean: "Crypticity and functional distribution of the membrane associated alpha-L-fucosidase of human sperm." in: Molecular reproduction and development, Vol. 74, Issue 6, pp. 758-66, 2007 |
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Bilder des Herstellers |