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CALEB is transiently required for synapse maturation in the cerebellum.
Despite the previously reported upregulation of Cspg5 during retinal degeneration in Rpe65 (zeige RPE65 ELISA Kits)/ mice, no protective effect or any involvement of Cspg5 in disease progression was identified.
there is a glycosylation site for chondroitin sulfate on the neural part-time proteoglycan (zeige Vcan ELISA Kits), neuroglycan C
neuroglycan C is a novel component of midkine (zeige MDK ELISA Kits) receptors involved in process elongation
PI3K-Akt (zeige AKT1 ELISA Kits)-mammalian target of rapamycin (mTOR (zeige FRAP1 ELISA Kits)) signaling pathway and PKC (zeige PKC ELISA Kits) are important for CALEB/NGC-induced stimulation of dendritic branching. CALEB/NGC-induced spine morphogenesis is independent of PI3K but depends on PKC (zeige PKC ELISA Kits).
During retinal degeneration in Rpe65 (zeige RPE65 ELISA Kits)-/- mice, neuroglycan C(NGC) expression is induced in neural retina, but not in retinal pigment epithelium, where NGC is expressed at highest levels.
results suggest that NGC may be a novel candidate gene, and neuregulin signaling pathways may play an important role in schizophrenia
NGC IV, which was first found in the present study, had the shortest cytoplasmic domain among the four variants
The protein encoded by this gene is a proteoglycan that may function as a neural growth and differentiation factor. Several transcript variants encoding different isoforms have been found for this gene.
chondroitin sulfate proteoglycan 5 (neuroglycan C)
, chondroitin sulfate proteoglycan 5
, acidic leucine-rich EGF-like domain-containing brain protein
, neuroglycan C
, epidermal growth factor