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The authors find that UCHL3 regulates COPS5 (zeige COPS5 Proteine)-dependent deneddylation of Cullin1, which is an essential component of SCF (zeige KITLG Proteine)(beta-TrCP (zeige BTRC Proteine)) complex and associated with SCF (zeige KITLG Proteine)(beta-TrCP (zeige BTRC Proteine)) activities. The authors further demonstrate that UCHL3 upregulates the levels of SCF (zeige KITLG Proteine)(beta-TrCP (zeige BTRC Proteine)) substrates including IFN-I receptor IFNAR1 (zeige IFNAR1 Proteine), which enhances IFN-I mediated signaling pathway and antiviral activity.
Study demonstrated positive correlations between the level and activity of UCHL3 and sperm characteristics and function suggesting that UCHL3 may play a role in male infertility.
Using a series of engineered protein substrates, which are similar in size yet differ in secondary structure, we demonstrate that thermal stability is a key factor that significantly affects UCH-L3 hydrolysis.
UCH-L3 is a novel regulator of epithelial-mesenchymal transition and cell migration in prostate cancer cells.
Data identified of UCHL3 as an essential deubiquitinase in adipogenesis.
impaired UCH-L3 function may contribute to the accumulation of full length UBB (zeige UBB Proteine)(+1) in various pathologie
1.45 A resolution crystal structure of human UCH-L3 in complex with the inhibitor ubiquitin vinylmethylester, an inhibitor that forms a covalent adduct with the active site cysteine of ubiquitin-specific proteases
Upregulation of UCH-L3 is associated with Uterine Cervical Neoplasms
Substrate filtering by the active site crossover loop in UCHL3 revealed by sortagging and gain-of-function mutations.
These results indicate that mono-Ub and Ub dimers may regulate the enzymatic functions of UCH-L1 (zeige UCHL1 Proteine) and UCH-L3, respectively, in vivo.
Data suggest that the activity of oocyte UCHL-1 (zeige UCHL1 Proteine) and -3 contributes to oocyte maturation by regulating the oocyte cortex and meiotic spindle.
subfertile Uchl1(gad-/-) mutant mice showed an intriguing pattern of switched UCH localization, with UCHL3 replacing UCHL1 (zeige UCHL1 Proteine) in the oocyte cortex
impaired UCH-L3 function may contribute to the accumulation of full length UBB (zeige UBA52 Proteine)(+1) in various pathologie
Results suggest that Uch-L3 enhances osteoblast differentiation through the stabilization of Smad1 (zeige SMAD1 Proteine) signaling
Polyubiquitinated proteins accumulate in skeletal muscle as well as in mouse embryonic fibroblasts derived from Uchl3-deficient mice.
Results suggest that UCH-L3 promotes adipogenesis by enhancing insulin (zeige INS Proteine) signaling in a hydrolase activity-dependent manner.
The role of ubiquitin C-terminal hydrolase (zeige UCHL1 Proteine) (UCH)-L3 in the regulation of AMP-activated protein kinase (zeige PRKAA2 Proteine) activity and whole-body energy metabolism are reportedl
UCH-L3 regulates the apical membrane recycling of the epithelial sodium channel
Data show that Uchl3 and mitofilin are differentially expressed in the hippocampi of inbred senescence-acclerated mice compared to normally-aging mice.
swine UCHL3, RIT1 (zeige RIT1 Proteine) and CCND3 (zeige CCND3 Proteine) genes were differentially expressed in tissues including small intestine, large intestine, liver, muscle, fat, lung, spleen and kidney
The protein encoded by this gene is a member of the deubiquitinating enzyme family. Members of this family are proteases that catalyze the removal of ubiquitin from polypeptides and are divided into five classes, depending on the mechanism of catalysis. This protein may hydrolyze the ubiquitinyl-N-epsilon amide bond of ubiquitinated proteins to regenerate ubiquitin for another catalytic cycle. Alternative splicing results in multiple transcript variants that encode different protein isoforms.
ubiquitin carboxyl-terminal hydrolase isozyme L3
, ubiquitin thioesterase L3
, ubiquitin thiolesterase
, ubiquitin carboxyl-terminal hydrolase-6
, ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
, ubiquitin carboxyl-terminal esterase L4