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UCHL1 inhibits autophagy and is depending on its de-ubiquitinating activity.
Uchl1 concentrations in the blood plasma of boys with cryptorchidism, may reflect the heat-induced apoptosis of germ cells
Overexpression of UCHL1 is associated with thermal injury.
UCHL1 localizes to TTAGGG repeats at telomeres and interstitial telomeric sequences. A weak or transient interaction between UCHL1 and the shelterin complex was confirmed by immunoprecipitation and proximity ligation assays.
detection of significantly higher levels of UCH-L1 in patients with ischemic stroke and intracranial hemorrhage compared to patients with metabolic disorder induced impaired consciousness and healthy volunteers
This study also showed that UCH-L1 promotes angiogenesis of HUVECs, as well as invasion in cancer cells, by up-regulating ROS (zeige ROS1 Proteine) by deubiquitination of NOX4 (zeige NOX4 Proteine), suggesting that UCH-L1 plays a key role in angiogenesis of HUVECS by regulating ROS (zeige ROS1 Proteine) levels by deubiquitination of NOX4 (zeige NOX4 Proteine).
Familial mutations and post-translational modifications of UCH-L1 in Parkinson's disease have been summarized. (Review)
Aberrant expression of UCHL1 in pediatric high-grade gliomas may promote cell invasion, transformation, and self-renewal properties, at least in part, by modulating Wnt (zeige WNT2 Proteine)/Beta catenin (zeige CTNNB1 Proteine) activity
Suppression of MITF (zeige MITF Proteine) activity by UCHL1 via protein degradation might aid in the development of new therapeutic approaches for melanoma or dyspigmentation disorders.
Overexpression of UCH-L1 in MCF7 cells up-regulated MDR1, CD147, MMP2 (zeige MMP2 Proteine), and MMP9 (zeige MMP9 Proteine), which conferred multidrug resistance and promoted migration/invasion.
The elevation in UCH-L1 concentration is consistent with the severity of neural apoptosis following DHCA.
Data report that ubiquitin carboxy-terminal hydrolase 1 is expressed in spermatogonia located at the basement membrane of seminiferous tubules at high and low levels, but not in differentiated germ cells distant from the BM.
These data indicate that antipolyspermy defense in bovine oocytes may rely on UCHL1-controlled functioning of These data indicate that antipolyspermy defense in bovine oocytes may rely on UCHL1-controlled functioning of cortical granules.
Post-transcriptional loss of UCHL1 following status epilepticus is deleterious to neuronal survival.
The UCHL1 may play a role in myogenesis by promoting myoblast proliferation and inhibiting differentiation.
our study provides novel insights into the mechanisms of UCH-L1-mediated neurobiological functions and suggests that ubiquitination is an important regulatory signal for TrkB (zeige NTRK2 Proteine)
Effects of Ubiquitin C-Terminal Hydrolase L1 (UCH-L1) inhibition on sperm incorporation and cortical tension in mouse eggs.
The neuronal marker UCH-L1 is induced in, and specifically augments the oncogene (zeige RAB1A Proteine)-induced transformation of, germinal center B cells.
Pharmacological inhibition of UCHL1 exacerbates rather than ameliorates disease symptoms in a mouse model of SMA (zeige SMN1 Proteine). Thus, pharmacological inhibition of UCHL1 is not a viable therapeutic target for SMA (zeige SMN1 Proteine).
Parkin (zeige PARK2 Proteine) mediates K63-linked polyubiquitination of UCH-L1 in cooperation with the Ubc13 (zeige UBE2N Proteine)/Uev1a E2 ubiquitin-conjugating enzyme (zeige UBE2L6 Proteine) complex and promotes UCH-L1 degradation by the autophagy-lysosome pathway.
defective UCHL1 function may be an early contributor to vulnerability of pancreatic beta-cells for protein misfolding and proteotoxicity, hallmark defects in islets of T2DM
UCH-L1 facilitates PDGF (zeige PDGFA Proteine)-BB-induced suppression of autophagic degradation of p21WAF1/Cip1 proteins in cardiac fibroblasts
UCHL1 upregulation in ACTN4 (zeige ACTN4 Proteine)-associated FSGS (zeige ACTN4 Proteine).
There was no difference in enteric neuronal density and distribution in the groups of animals with intestinal disease compared with those without, apart from two (out of 28) horses with intestinal disease that showed reduction in PGP 9.5 immunoreactivity.
The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.
neuron cytoplasmic protein 9.5
, ubiquitin C-terminal hydrolase
, ubiquitin carboxyl-terminal hydrolase isozyme L1
, ubiquitin thioesterase L1
, ubiquitin C-terminal hydrolase-L1
, ubiquitin carboxyl-terminal hydrolase L1
, ubiquitin thiolesterase L1
, PGP 9.5
, ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
, ubiquitin carboxyl-terminal esterase L1
, ubiquitin carboxy-terminal hydrolase L1
, gracile axonal dystrophy
, protein gene product 9.5