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anti-Human Tryptophan Hydroxylase 1 Antikörper:
anti-Mouse (Murine) Tryptophan Hydroxylase 1 Antikörper:
anti-Rat (Rattus) Tryptophan Hydroxylase 1 Antikörper:
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Human Polyclonal Tryptophan Hydroxylase 1 Primary Antibody für IHC (fro), IHC - ABIN152521
Haycock, Kumer, Lewis, Vrana, Stockmeier: A monoclonal antibody to tryptophan hydroxylase: applications and identification of the epitope. in Journal of neuroscience methods 2002
Show all 2 Pubmed References
Human Polyclonal Tryptophan Hydroxylase 1 Primary Antibody für IHC (fro), WB - ABIN2476982
Lowry, Rodda, Lightman, Ingram et al.: Corticotropin-releasing factor increases in vitro firing rates of serotonergic neurons in the rat dorsal raphe nucleus: evidence for activation of a topographically organized mesolimbocortical ... in The Journal of neuroscience : the official journal of the Society for Neuroscience 2000
The catalytic domain of TPH1 shares a sequence identity of 81% with TPH2 (zeige TDO2 Antikörper). Despite the high sequence identity, differences in the kinetic parameters of the isoforms have been identified; i.e., only TPH1 displays substrate tryptophan inhibition.
results confirm the role of TPH1, TPH2 (zeige TDO2 Antikörper), 5HT2A, CRHR1 (zeige CRHR1 Antikörper) and ACP1 (zeige ACP1 Antikörper) variants in the risk of suicidal behavior.
Tryptophan Hydroxylase 1 Variant rs1800532 is associated with Suicide Attempt in Serbian Psychiatric Patients.
This study demonstrates that both TPH1 and TPH2 (zeige TDO2 Antikörper) are expressed in human and mouse placenta throughout pregnancy and helps to better understand the placental serotonin system, which is crucial for healthy pregnancy and fetal development.
Genetic association studies have revealed contradictory results about the effect of the TPH1 A218C (rs1800532) polymorphism on suicidal behavior in different populations. Investigated A218C polymorphism in 109 suicide attempters and 98 healthy controls. Our results provide evidence that A allele of TPH1 A218C polymorphism may be associated with suicidal behavior in Turkish population
The regulatory domain of isoform 1 of tryptophan hydroxylase was expressed and purified; mutagenesis of Cys64 was required to prevent formation of disulfide-linked dimers.
Associations between serotonin transporter (zeige SLC6A4 Antikörper) gene and tryptophan hydroxylase 1 polymorphisms and several Temperament and Character Inventory dimensions and subdimensions were revealed in subjects with bipolar disorder.
there was a significant interaction between the TPH1 A218C A/C and 5-HTTLPR (zeige SLC6A4 Antikörper) S+ gene polymorphisms in opiate-dependent, but not in alcohol-dependent patients.
Polymorphisms in the TPH1 gene may be represented by diminished activity in lateral areas of the PFC (zeige CFP Antikörper) underlying response inhibition.
Decoy receptor 3 (zeige TNFRSF6B Antikörper) regulates the expression of tryptophan hydroxylase 1 in rheumatoid synovial fibroblasts
The authors show that the interactions between daf-7 and tph-1 regulate redundancy and synergy among neurons in food encoding through coordinated control of circuit-level signal and noise properties.
A gene-expression-based neural code for food abundance that modulates lifespan includes daf-7 that primarily regulates gene-expression variability, while tph-1 primarily regulates the dynamic range of gene-expression responses.
tph-1 mutants failed to exhibit ethanol interference with gustatory plasticity in Caenorhabditis elegans
Prolactin (zeige PRL Antikörper)-induced Tph1 expression.
Tph1-deficient mice fed a high-fat diet (HFD) are protected from obesity, insulin (zeige INS Antikörper) resistance and nonalcoholic fatty liver disease (NAFLD (zeige TSC2 Antikörper)) while exhibiting greater energy expenditure by brown adipose tissue.
Lack of tryptophan hydroxylase-1 in mice results in gait abnormalities.
ZBP-89 (zeige ZNF148 Antikörper) directly binds to the Tph1 promoter, which is required for its basal and butyrate-inducible expression.
TPH1 deficiency or inhibition reduces allergic airway inflammation. Platelet-derived 5-HT (zeige DDC Antikörper) is pivotal in AAI and lack of 5-HT (zeige DDC Antikörper) leads to impaired Th2 priming capacity of bone marrow dendritic cells.
Data indicate that tryptophan hydroxylase (Tph)1-deficient mice, lacking non-neuronal serotonin, showed mild leukocytosis.
Data show that Tph-1 (tryptophan hydroxylase-1) is a potent regulator of immunity.
Parallel to Tph1 mRNA and protein induction, islet serotonin content increased to a peak level that was 200-fold higher than basal. Interestingly, only a subpopulation of the beta cells was serotonin-positive in vitro and in vivo.
nonneuronal tph1 gene has a role in cardiac function with peripheral serotonin
Review. TPH1 is expressed in the pineal gland and the enterochromaffin cells. Loss of TPH1 gene expression, and thus of peripheral 5-HT (zeige DDC Antikörper), leads to a cardiac dysfunction phenotype.
This gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others.
, indoleacetic acid-5-hydroxylase
, tryptophan 5-hydroxylase 1
, tryptophan 5-monooxygenase 1
, tryptophan hydroxylase (tryptophan 5-monooxygenase)
, tryptophan hydroxylase (tryptophan 5-monooxygenase
, tryptophan hydroxylase 1 (tryptophan 5-monooxygenase)
, TryPtophan Hydroxylase family member (tph-1)
, tryptophan 5-hydroxylase
, tryptophan 5-monooxygenase
, secretion regulating guanine nucleotide exchange factor
, tryptophan hydroxylase 1
, tryptophan 5-hydroxylase 1-like
, tryptophan hydroxylase