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anti-Human VAV3 Antikörper:
anti-Rat (Rattus) VAV3 Antikörper:
anti-Mouse (Murine) VAV3 Antikörper:
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Human Polyclonal VAV3 Primary Antibody für ELISA, WB - ABIN268548
Movilla, Bustelo: Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins. in Molecular and cellular biology 1999
Inactivation of Vav3 in vivo resulted in increased vascular leakage, highlighting its function as a key regulator of barrier stability.
Vav3 in peripheral blood may serve as a biomarker for gastric cancer, and to predict the lymphatic metastasis in gastric cancer.
The N-terminal truncated Vav3.1 may be decisively involved in mechanisms causing genuine multi-drug resistance.
VAV3 polymorphisms associate with cardiovascular risk factors and target organ damage.
High VAV3 variant expression is associated with endometrial cancer.
Results identified the diffuse B-cell lymphoma homology (DH) domain of Vav3 that interacts with the N-terminal region of AR-V7 (splice variants) and increases its expression in castration-resistant prostate cancer (CRPC). This interaction disrupted AR-V7 interaction with other AR coactivators like Src1 and Vav2.
We then explore the consequences of phorbol ester binding to a modified Vav3 in which the C1 domain has been altered to allow phorbol ester binding. We find both disruption of the guanyl nucleotide exchange activity of the modified Vav 3 as well as a shift in localization to the membrane upon phorbol ester treatment.
Overexpression of Vav3 is an independent risk factor for prognosis of gastric cancer, and can be used as a prognostic indicator.
Vav3 is a novel TRAF6 interaction partner that functions in the activation of cooperative signaling between T6BSs and the IVVY motif in the RANK signaling complex.
this study shows that the anti-tumor effects of astragaloside IV are mediated by the downregulation of Vav3-mediated Rac1/MAPK activation
Our results indicated that individuals carrying the VAV3 rs7528153 TT genotype were at a significantly increased risk of developing Paget's Disease of Bone
Vav3 was accumulated in cell protrusions, contributed to the formation of membrane protrusions, and thereby increased the motility and invasiveness of pancreatic ductal adenocarcinoma cells
Vav3 inhibition can suppress cell activity and promote apoptosis by regulating the apoptosis-related genes through the ERK pathway
Data show that microRNA miR-499-5p targeted 3' untranslated regions (3'-UTR) of vav 3 oncogene protein (VAV3).
Results found that OSR2, VAV3, and PPFIA3 were significantly hypermethylated in gastric cancer (GC) patients offering a good alternative in a simple, promising, and noninvasive detection of GC.
Data show although no any significant differences between patient groups and lean subjects of proteins SYT4, BAG3, APOA1, and VAV3, except for VGF protein, there was a trend between the expression of these four genes and their protein levels.
VAV3 overexpression is a novel biomarker for poor prognosis and survival in ovarian carcinoma.
VAV3 overexpression could be a useful marker for predicting the outcomes of CRC patients and that VAV3 targeting represents a potential modality for treating CRC
discrete and different functions of VAV3.1 in metastasis and tumorigenesis are conceivable.
Inhibition of Vav3 could reverse the drug resistance of gastric cancer cells by downregulating JNK signaling pathway.
This study highlights Vav3 as a novel regulator of oligodendrocyte maturation and remyelination, suggesting that manipulation of the Vav3-dependent signaling pathway could help to improve myelin repair.
we identified novel transcriptional targets of KLF6 in HCC cells including VAV3, a known activator of the RAC1 small GTPase. Indeed, RAC1 activity is increased in KLF6-knockdown cells in a VAV3-dependent manner, and knockdown of either RAC1 or VAV3 impairs HCC cell migration. Together, our data demonstrate a novel function for KLF6 in constraining HCC dissemination through the regulation of a VAV3-RAC1 signaling axis.
Vav3 is a regulator of retinal progenitor cell differentiation, thus highlighting a novel role for guanine nucleotide exchange factors in retinogenesis.
Platelet P-Rex and Vav family Rac-GEFs play important proinflammatory roles in leukocyte recruitment.
chow diet-fed Vav3 knockout mice develop an incomplete postreceptor insulin state characterized by typical liver and plasma metabolic syndrome-like pathophysiologies that is not associated to other defects such as white adipocyte hypertrophy and obesity
Data demonstrate that the co-expression of the exchange factors Vav2 and Vav3 is critical for the development of this tumor type.
Vav2 and Vav3 are required for normal peripheral nerve degeneration/regeneration, revascularization and functional recovery.
Vav3 collaborates with p190-BCR-ABL in lymphoid progenitor leukemogenesis, proliferation, and survival.
Dectin-1 activates the integrin Mac-1 in neutrophils via Vav1 and Vav3 signaling to promote Candida albicans clearance.
study discloses an essential and nonredundant role for this Vav family member in axon guidance events in brainstem neurons that control blood pressure and respiratory rates
CD36 contributes to activation of Vav-1, -2, and -3 in aortae from hyperlipidemic mice
Vav3 is a bona fide Ahr target that is in charge of a limited subset of the developmental and physiological functions controlled by this transcriptional factor.
Data show that Vav2/Vav3-deficient mice show early onset of iridocorneal angle changes and elevated intraocular pressure, with subsequent selective loss of retinal ganglion cells and optic nerve head cupping, which are the hallmarks of glaucoma.
These results indicate that Vav3 function contributes to the timely developmental progression of the cerebellum.
Genetic mapping, sequencing, and evidence of gene expression indicate that alteration of VAV3 expression is an etiological factor in the development of autoimmune pancreatic beta-cell destruction in nonobese diabetic (NOD) mice.
Vav1 and Vav3 proteins play an essential role coupling beta2 to Rho GTPases and regulating multiple integrin-induced events important in leukocyte adhesion and phagocytosis.
Three Vav proteins (vav1,vav2 and vav3) function specifically in distinct pathways that trigger NK cell cytotoxicity.
results demonstrate that Vav3 and Vav1 play crucial but redundant roles in the activation of phospholipase C gamma 2 by glycoprotein GPVI
Vav3, a Rho family guanine nucleotide exchange factor, is essential for stimulated osteoclast activation and bone density in vivo
This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
vav 3 oncogene
, guanine nucleotide exchange factor VAV3
, vav 3 protein