anti-Maus LAT2 Antikörper für Immunocytochemistry

Recommended LAT2 Antibody

Antigen
Linker For Activation of T Cells Family, Member 2 (LAT2) Antikörper
  • LAB
  • NTAL
  • WBSCR15
  • WBSCR5
  • WSCR5
  • LAT2
  • MGC139435
  • Ntal
  • Wbscr5
  • AW125574
  • Wbscr15
  • linker for activation of T-cells family member 2
  • linker for activation of T cells family, member 2
  • LAT2
  • Lat2
Epitop
AA 30-203
16
15
11
11
11
10
9
8
8
6
5
5
5
4
2
2
2
2
2
1
1
1
1
1
Reaktivität
Maus, Ratte (Rattus)
124
42
30
3
3
3
1
1
1
1
1
Wirt
Kaninchen
108
29
14
Klonalität
Polyklonal
Konjugat
Dieser LAT2 Antikörper ist unkonjugiert
8
8
6
3
3
3
2
2
2
2
2
2
Applikation
Immunocytochemistry (ICC), Western Blotting (WB)
132
43
32
29
16
13
11
6
5
3
3
2
1
Optionen

Bilder

Produktnummer ABIN125755
$ 428.84
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Clonality References Details
21.092297 ABIN94439 ICC FACS IP WB Mouse IgG1 AA 91-243, Cytoplasmic Domain NAP-07 6
21.092297 ABIN94440 FACS ICC IP WB PE Mouse IgG1 AA 91-243, Cytoplasmic Domain NAP-07 4
7 ABIN5013879 ICC IHC WB Rabbit IgG AA 29-193 Polyclonal 0
1 ABIN207049 Inhibition FACS ICC IP WB Mouse IgG1 AA 91-243 NAP-07 0
1 ABIN207126 ICC WB Rabbit AA 30-203 Polyclonal 0
1 ABIN2742550 ICC WB Rabbit AA 30-203 Polyclonal 0
1 ABIN3200731 FACS ICC IP WB PE Mouse IgG1 Cytoplasmic Domain NAP-07 0
1 ABIN3200730 FACS ICC IP WB Mouse IgG1 Cytoplasmic Domain NAP-07 0
1 ABIN3200728 ICC WB Rabbit Polyclonal 0
-10.110059 ABIN268974 CyTOF FACS ICC IF IP WB Mouse IgG1 NAP-07 0
-10.110059 ABIN4340809 ICC IF WB Rabbit AA 30-203 Polyclonal 0
-13.110059 ABIN5946787 FACS ICC IF Janelia Fluor® 549 Mouse IgG1 AA 91-244 NAP-07 0
-13.110059 ABIN5946788 FACS ICC IF Janelia Fluor® 646 Mouse IgG1 AA 91-244 NAP-07 0
-13.110059 ABIN4340815 FACS ICC IF WB DyLight 755 Mouse IgG1 NAP-07 0
-13.110059 ABIN4340816 FACS ICC IF WB DyLight 680 Mouse IgG1 NAP-07 0
-13.110059 ABIN4340817 FACS ICC IF WB DyLight 488 Mouse IgG1 NAP-07 0
-13.110059 ABIN4340826 FACS ICC IF WB Alexa Fluor 405 Mouse IgG1 NAP-07 0
-13.110059 ABIN4340827 FACS ICC IF WB Alexa Fluor 488 Mouse IgG1 NAP-07 0
-13.110059 ABIN4340828 FACS ICC IF WB Alexa Fluor 647 Mouse IgG1 NAP-07 0
-13.110059 ABIN4340829 FACS ICC IF WB Alexa Fluor 700 Mouse IgG1 NAP-07 0

General

Antigen Linker For Activation of T Cells Family, Member 2 (LAT2) Antikörper
Epitop AA 30-203
(16), (15), (11), (11), (11), (10), (9), (8), (8), (6), (5), (5), (5), (4), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Reaktivität Maus, Ratte (Rattus)
(124), (42), (30), (3), (3), (3), (1), (1), (1), (1), (1)
Wirt Kaninchen
(108), (29), (14)
Klonalität
Polyklonal
Konjugat Dieser LAT2 Antikörper ist unkonjugiert
(8), (8), (6), (3), (3), (3), (2), (2), (2), (2), (2), (2)
Applikation Immunocytochemistry (ICC), Western Blotting (WB)
(132), (43), (32), (29), (16), (13), (11), (6), (5), (3), (3), (2), (1)
Pubmed 5 Publikationen vorhanden
Hersteller

Produktdetails anti-LAT2 Antikörper

Target Details LAT2 Anwendungsinformationen Handhabung Referenzen für anti-LAT2 Antikörper (ABIN125755) Bilder
Spezifität The polyclonal antibody reacts with Non-T cell Activation Linker (NTAL), also known as LAB (linker of activated B cells), a 25 kDa transmembrane adaptor protein present in membrane microdomains (rafts) of B cells, NK cells and myeloid cells.
Keine Kreuzreaktivität Human
Kreuzreaktivität (Details) Mouse, Rat, Other species Not tested
Reinigung Purified from rabbit serum by affinity chromatography
Reinheit > 95 % (by SDS-PAGE)
Immunogen Recombinant mouse NTAL (aa 30-203).
Plasmids, Primers & others

Target Details LAT2

Produktdetails anti-LAT2 Antikörper Anwendungsinformationen Handhabung Referenzen für anti-LAT2 Antikörper (ABIN125755) Bilder zurück nach oben
Antigen
Andere Bezeichnung NTAL / LAB (LAT2 Antibody Abstract)
Hintergrund NTAL (Non-T cell activation linker), also known as LAB (Linker for activation of B cells), is a 30 kDa double-palmitoylated transmembrane adaptor protein expressed by B cells, NK cells, mast cells and macrophages. It is a negative regulator of early stages of BCR-dependent B cell signaling and serves as a negative regulator also in mast cells. However, in mast cells, NTAL also contributes to some activation processes, partially overlapping with LAT function.
Pathways Fc-epsilon Rezeptor Signalübertragung

Anwendungsinformationen

Produktdetails anti-LAT2 Antikörper Target Details LAT2 Handhabung Referenzen für anti-LAT2 Antikörper (ABIN125755) Bilder zurück nach oben
Applikations-hinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-LAT2 Antikörper Target Details LAT2 Anwendungsinformationen Referenzen für anti-LAT2 Antikörper (ABIN125755) Bilder zurück nach oben
Konzentration 1 mg/mL
Buffer Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Do not freeze.
Lagerung 4 °C
Informationen zur Lagerung Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.

Referenzen für anti-LAT2 Antikörper (ABIN125755)

Produktdetails anti-LAT2 Antikörper Target Details LAT2 Anwendungsinformationen Handhabung Bilder zurück nach oben
Allgemeine Veröffentlichungen

Yamasaki, Ishikawa, Sakuma, Kanagawa, Cheng, Malissen, Saito: "LAT and NTAL mediate immunoglobulin E-induced sustained extracellular signal-regulated kinase activation critical for mast cell survival." in: Molecular and cellular biology, Vol. 27, Issue 12, pp. 4406-15, 2007

Horejsí, Zhang, Schraven: "Transmembrane adaptor proteins: organizers of immunoreceptor signalling." in: Nature reviews. Immunology, Vol. 4, Issue 8, pp. 603-16, 2004

Produkt verwendet in:

Lebduska, Korb, T?mová, Heneberg, Dráber: "Topography of signaling molecules as detected by electron microscopy on plasma membrane sheets isolated from non-adherent mast cells." in: Journal of immunological methods, Vol. 328, Issue 1-2, pp. 139-51, 2007

Heneberg, Lebduska, Dráberová, Korb, Dráber: "Topography of plasma membrane microdomains and its consequences for mast cell signaling." in: European journal of immunology, Vol. 36, Issue 10, pp. 2795-806, 2006

Volná, Lebduska, Dráberová, Símová, Heneberg, Boubelík, Bugajev, Malissen, Wilson, Horejsí, Malissen, Dráber: "Negative regulation of mast cell signaling and function by the adaptor LAB/NTAL." in: The Journal of experimental medicine, Vol. 200, Issue 8, pp. 1001-13, 2004

Bilder

Produktdetails anti-LAT2 Antikörper Target Details LAT2 Anwendungsinformationen Handhabung Referenzen für anti-LAT2 Antikörper (ABIN125755) zurück nach oben
Bilder des Herstellers
Immunocytochemistry (ICC) image for anti-Linker For Activation of T Cells Family, Member 2 (LAT2) (AA 30-203) antibody (ABIN125755) Distribution of LAT and NTAL in separate clusters on mast cell plasma membrane sheets...
Immunocytochemistry (ICC) image for anti-Linker For Activation of T Cells Family, Member 2 (LAT2) (AA 30-203) antibody (ABIN125755) Distribution of LAT and NTAL in separate clusters on mast cell plasma membrane sheets...