anti-Human LAT2 Antikörper für Western Blotting

Recommended LAT2 Antibody

Antigen
Linker For Activation of T Cells Family, Member 2 (LAT2) Antikörper
  • LAB
  • NTAL
  • WBSCR15
  • WBSCR5
  • WSCR5
  • LAT2
  • MGC139435
  • Ntal
  • Wbscr5
  • AW125574
  • Wbscr15
  • linker for activation of T-cells family member 2
  • linker for activation of T cells family, member 2
  • LAT2
  • Lat2
Epitop
AA 91-243, Cytoplasmic Domain
15
14
11
11
11
10
9
8
8
6
5
5
5
5
2
2
2
2
2
1
1
1
1
1
Reaktivität
Human
123
43
31
3
3
3
1
1
1
1
1
Wirt
Kaninchen
108
29
14
Klonalität
Polyklonal
Konjugat
Dieser LAT2 Antikörper ist unkonjugiert
8
8
6
3
3
3
2
2
2
2
2
2
Applikation
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
132
43
32
29
15
13
12
6
5
3
3
2
1
Optionen

Bilder

Produktnummer ABIN302075
$ 428.84
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Clonality References Details
21.08554 ABIN94439 ICC FACS IP WB Mouse IgG1 AA 91-243, Cytoplasmic Domain NAP-07 6
21.08554 ABIN94440 FACS ICC IP WB PE Mouse IgG1 AA 91-243, Cytoplasmic Domain NAP-07 4
18.08554 ABIN94442 IHC (p) IP WB Mouse IgG2a AA 196-212 NAP-03 2
17.443338 ABIN2856388 WB Rabbit IgG C-Term Polyclonal 0
16.857798 ABIN1859616 ICC IHC WB Rabbit IgG AA 30-209 Polyclonal 0
16.857798 ABIN2937601 IF/ICC IHC IP WB Rabbit AA 30-209 Polyclonal 0
16.58554 ABIN1590104 ELISA WB Goat Internal Region Polyclonal 0
13.585541 ABIN6388317 ELISA WB Rabbit IgG AA 80-160 Polyclonal 0
13.585541 ABIN6390516 ELISA WB Rabbit IgG Polyclonal 0
13.585541 ABIN2145611 IHC ELISA WB Rabbit IgG Polyclonal 0
13.585541 ABIN6133788 WB Rabbit Polyclonal 0
7.8577986 ABIN4899019 CyTOF FACS WB Mouse IgG2b AA 1-243 440005 0
7.8577986 ABIN4899020 FACS WB Sheep IgG AA 1-243 Polyclonal 0
7.8577986 ABIN5582405 IHC (p) WB Rabbit IgG Polyclonal 0
7.8577986 ABIN3031631 WB Rabbit IgG N-Term Polyclonal 0
7 ABIN239823 Inhibition IHC IHC (p) IP WB Mouse IgG2a AA 196-212 NAP-03 0
7 ABIN462419 Inhibition IHC IHC (p) WB Rabbit AA 91-243 Polyclonal 0
7 ABIN238343 IHC (p) WB Rabbit AA 91-243 Polyclonal 3
5.5 ABIN120727 FACS IF IP WB Mouse IgG1 AA 91-244 NAP-07 4
5.5 ABIN536095 FACS IF IP WB Mouse IgG1 NAP-07 3

General

Antigen Linker For Activation of T Cells Family, Member 2 (LAT2) Antikörper
Epitop AA 91-243, Cytoplasmic Domain
(15), (14), (11), (11), (11), (10), (9), (8), (8), (6), (5), (5), (5), (5), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Reaktivität Human
(123), (43), (31), (3), (3), (3), (1), (1), (1), (1), (1)
Wirt Kaninchen
(108), (29), (14)
Klonalität
Polyklonal
Konjugat Dieser LAT2 Antikörper ist unkonjugiert
(8), (8), (6), (3), (3), (3), (2), (2), (2), (2), (2), (2)
Applikation Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(132), (43), (32), (29), (15), (13), (12), (6), (5), (3), (3), (2), (1)
Pubmed 3 Publikationen vorhanden
Hersteller

Produktdetails anti-LAT2 Antikörper

Target Details LAT2 Anwendungsinformationen Handhabung Referenzen für anti-LAT2 Antikörper (ABIN302075) Bilder
Spezifität The polyclonal antibody recognizes the defined epitope (aa 91-243) of human Non-T cell Activation Linker (NTAL), also known as LAB (linker of activated B cells), a 30 kDa transmembrane adaptor protein present in membrane microdomains (rafts) of B cells, NK cells and myeloid cells.
Keine Kreuzreaktivität Maus
Kreuzreaktivität (Details) Human
Reinigung Purified from rabbit serum by affinity chromatography
Reinheit > 95 % (by SDS-PAGE)
Immunogen Recombinant cytoplasmic domain (aa 91-243) of human NTAL.
Plasmids, Primers & others

Target Details LAT2

Produktdetails anti-LAT2 Antikörper Anwendungsinformationen Handhabung Referenzen für anti-LAT2 Antikörper (ABIN302075) Bilder zurück nach oben
Antigen
Andere Bezeichnung NTAL / LAB (LAT2 Antibody Abstract)
Hintergrund NTAL (Non-T cell activation linker), also known as LAB (Linker for activation of B cells), is a 30 kDa double-palmitoylated transmembrane adaptor protein expressed by B cells, NK cells, mast cells and macrophages. It is a negative regulator of early stages of BCR-dependent B cell signaling and serves as a negative regulator also in mast cells. However, in mast cells, NTAL also contributes to some activation processes, partially overlapping with LAT function.
Pathways Fc-epsilon Rezeptor Signalübertragung

Anwendungsinformationen

Produktdetails anti-LAT2 Antikörper Target Details LAT2 Handhabung Referenzen für anti-LAT2 Antikörper (ABIN302075) Bilder zurück nach oben
Applikations-hinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-LAT2 Antikörper Target Details LAT2 Anwendungsinformationen Referenzen für anti-LAT2 Antikörper (ABIN302075) Bilder zurück nach oben
Konzentration 1 mg/mL
Buffer Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Do not freeze.
Lagerung 4 °C
Informationen zur Lagerung Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.

Referenzen für anti-LAT2 Antikörper (ABIN302075)

Produktdetails anti-LAT2 Antikörper Target Details LAT2 Anwendungsinformationen Handhabung Bilder zurück nach oben
Allgemeine Veröffentlichungen

Yamasaki, Ishikawa, Sakuma, Kanagawa, Cheng, Malissen, Saito: "LAT and NTAL mediate immunoglobulin E-induced sustained extracellular signal-regulated kinase activation critical for mast cell survival." in: Molecular and cellular biology, Vol. 27, Issue 12, pp. 4406-15, 2007

Horejsí, Zhang, Schraven: "Transmembrane adaptor proteins: organizers of immunoreceptor signalling." in: Nature reviews. Immunology, Vol. 4, Issue 8, pp. 603-16, 2004

Produkt verwendet in:

Tkaczyk, Horejsi, Iwaki, Draber, Samelson, Satterthwaite, Nahm, Metcalfe, Gilfillan: "NTAL phosphorylation is a pivotal link between the signaling cascades leading to human mast cell degranulation following Kit activation and Fc epsilon RI aggregation." in: Blood, Vol. 104, Issue 1, pp. 207-14, 2004

Bilder

Produktdetails anti-LAT2 Antikörper Target Details LAT2 Anwendungsinformationen Handhabung Referenzen für anti-LAT2 Antikörper (ABIN302075) zurück nach oben
Bilder des Herstellers
Western Blotting (WB) image for anti-Linker For Activation of T Cells Family, Member 2 (LAT2) (AA 91-243), (Cytoplasmic Domain) antibody (ABIN302075) Western Blotting analysis (non-reducing conditions) of NTAL-transfected HEK-293 FT ce...
Immunohistochemistry (IHC) image for anti-Linker For Activation of T Cells Family, Member 2 (LAT2) (AA 91-243), (Cytoplasmic Domain) antibody (ABIN302075) Immunohistochemistry staining of human spleen (paraffin sections) with anti-NTAL poly...