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Human Polyclonal TRIB3 Primary Antibody für ICC, IF - ABIN252371
Loewen, Chen, Dudley, Sarthy, Mathura: Genomic response of hypoxic Müller cells involves the very low density lipoprotein receptor as part of an angiogenic network. in Experimental eye research 2009
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study proposes that Trb3 governs left-right (LR) axis patterning as a component of TGF-signaling in embryonic development
TRB3 (zeige TAS2R13 Antikörper) is overexpressed in lesions of patients with psoriasis.
tribbles (zeige TRIB1 Antikörper) pseudokinase 3 (TRB3 (zeige TAS2R13 Antikörper)) and sestrin 2 (zeige SESN2 Antikörper) may contribute to the development of obesity and its complications and can be considered interesting therapeutic target for the treatment of obesity
TRIB3, a single-domain protein with impaired kinase catalytic activity, has been described to perform a complex of roles, many of which are likely to be cell type-specific. (Review)
High TRB3 (zeige TAS2R13 Antikörper) expression is associated with basal-like breast cancer.
TRIB3 promotes acute promyelocytic leukemia (zeige PML Antikörper) progression through stabilization of the oncoprotein PML (zeige PML Antikörper)-RARalpha (zeige RARA Antikörper) and inhibition of p53 (zeige TP53 Antikörper)-mediated senescence.
Downregulation of TRIB3 is associated with lung cancer.
This study aims to investigate whether the Tribbles 3 Q84R polymorphism has profound effects on serum semaphorin 3E (zeige SEMA3E Antikörper) and what effect semaphorin 3E (zeige SEMA3E Antikörper) exerts on carotid atherosclerosis.
overexpression of TRIB3 is associated with tumor angiogenesis and a poor prognosis in patients with gastric cancer (GC) . Our findings indicate that TRIB3 is a promising target for antiangiogenic therapy in GC.
Our findings suggest that good glucose and blood pressure control exhibited greater benefits on vascular outcomes in patients with TRIB3 (rs2295490) G allele.
In this exploratory analysis, IRS1 (zeige IRS1 Antikörper), ENNP1 and TRIB3, known to be associated with type 2 diabetes and harboring genes playing a prominent role in mediating insulin (zeige INS Antikörper) signaling, may modulate a number of cardiometabolic phenotypes in patients of Italian ancestry with newly-diagnosed type 2 diabetes.
under nutrient-limiting conditions that stimulate ATF4 (zeige ATF4 Antikörper) activity, TRIB3 is implicated in the regulation of metabolic adaptation by restraining the transcription of Fgf21 (zeige FGF21 Antikörper).
Data (including data from studies in transgenic and mutant mice) suggest that Akt2 (zeige AKT2 Antikörper) plays critical role in type 1 diabetes in metallothionein (zeige MT Antikörper)-mediated preservation of cardiac insulin (zeige INS Antikörper)-stimulated metabolic signaling (insulin (zeige INS Antikörper) resistance) and preservation of cardiac function; this mechanism appear to involve inhibition of cardiac Trb3. (Akt2 (zeige AKT2 Antikörper) = protein kinase Akt-2 (zeige AKT2 Antikörper); Trb3 = tribbles (zeige TRIB1 Antikörper) pseudokinase 3)
restoration of TRB3 expression markedly abolished the effect of miR (zeige MLXIP Antikörper)-124 on hepatic TG metabolism.
TRB3 regulates protein synthesis and breakdown via the Akt (zeige AKT1 Antikörper)/mTOR (zeige FRAP1 Antikörper)/FoxO (zeige FOXO3 Antikörper) pathways in skeletal muscle.
Chac1 (zeige CHAC1 Antikörper) expression is detrimental to arsenite-treated cell survival and TRIB3 is critical for restraining the pro-death potential of Chac1 (zeige CHAC1 Antikörper) during arsenite stress.
Under physiological conditions, muscle TRIB3 also influences energy expenditure and substrate metabolism, indicating that the decrease and increase in muscle TRIB3 under fasting and nutrient excess, respectively, are critical for metabolic homeostasis.
In a knockout mouse model, Trib3 disruption modestly increased steady-state erythrocyte numbers and decreased mean corpuscular volume.
Palmitate increased TRB3 expression, activated IRE1alpha (zeige ERN1 Antikörper) signaling, and reduced the insulin (zeige INS Antikörper)-dependent Akt (zeige AKT1 Antikörper) phosphorylation. Knocking down TRB3 or IRE1alpha (zeige ERN1 Antikörper) did not prevent the inhibitory effect of palmitate on Akt (zeige AKT1 Antikörper) phosphorylation. Results support the idea that ER stress is not responsible for lipid-induced IR in C2C12 myotubes.
These data demonstrate that TRB3 inhibits insulin (zeige INS Antikörper) signaling in BAT (zeige BAAT Antikörper), resulting in impaired differentiation and function.
This work aimed to study the porcine tribbles homolog 3 (TRIB3) gene and to evaluate its association with meat quality and carcass traits in pigs.
The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1.
tribbles homolog 3
, tribbles homolog 3 (Drosophila)
, tribbles homolog 3-like
, neuronal cell death inducible putative kinase
, neuronal cell death-inducible putative kinase
, p65-interacting inhibitor of NF-kappa-B
, p65-interacting inhibitor of NF-kappaB
, induced in fatty liver dystrophy 2
, Neuronal cell death Inducible Putative Kinase
, tribbles 3