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This study identifies a novel signaling involving SYK/c-MYC/MALAT1 as a promising therapeutic target for the treatment of Ewing sarcoma.
Comparison of the distributions of tau pTyr18 and double-phosphorylated Syk in the transgenic mouse brain and human hippocampus showed that the phosphorylation of tyrosine 18 in tau already occurs at an early stage of tauopathy and increases with the progression of neurodegeneration. Syk appears unlikely to be a major kinase that phosphorylates tyrosine 18 of tau at the early stage of tauopathy.
Results show that Syk activation occurs following Abeta (zeige APP Proteine) deposition and the formation of tau pathological species. As Syk activation also promotes Abeta (zeige APP Proteine) formation and tau hyperphosphorylation, results suggest that Alzheimer's disease pathological lesions may be self-propagating via a Syk dependent mechanism highlighting Syk as an attractive therapeutic target for the treatment of Alzheimer's disease.
study reports that neutrophils constitutively express various Src (zeige SRC Proteine) family isoforms as well as Syk, and that inhibition of these protein tyrosine kinases selectively hinders inflammatory cytokine generation by acting posttranscriptionally
Cholesterol crystals activate specific cell signalling pathways which drive the production of inflammatory cytokines and degradative enzymes known to contribute to disease initiation and progression and are dependent on activation of Syk and PI3K (zeige PIK3CA Proteine)
Syk-induced signals in bone marrow stromal cell lines are mediated by phospholipase C (zeige PLC Proteine) gamma1 (PLCgamma1 (zeige PLCG1 Proteine)) in osteogenesis and PLCgamma2 (zeige PLCG2 Proteine) in adipogenesis.
AKT (zeige AKT1 Proteine) and 14-3-3 (zeige YWHAQ Proteine) proteins down-regulate the activity of several BCR (zeige BCR Proteine)-associated components, including BTK (zeige BTK Proteine), BLNK (zeige BLNK Proteine) and SYK and also inhibit SYK's interaction with Importin 7 (zeige IPO7 Proteine)
Expression of SYK and its splice variants was significantly lower in tumors with MSI, and in KRAS wild type, BRAF mutant and PTEN mutant tumors
combined use of butyrate and highly specific Syk inhibitor BAY61-3606 does not enhance differentiation and apoptosis of colonocytes. Instead, BAY completely abolishes butyrate-induced differentiation and apoptosis in a Syk- and ERK1/2-dependent manner.
Study demonstrates that redundant complexes formed by the mutant SYK(Y3F) protein allow it to maintain signaling to receptor-proximal interaction partners, resulting in proper initiation of BCR (zeige BCR Proteine)-proximal signals.
Syk kinase acts downstream of receptors controlling granule cells tangential migration
SYK could induce HO-1 (zeige HMOX1 Proteine) expression by regulating the Akt (zeige AKT1 Proteine) phosphorylation level in H9c2 with A/H injury, protecting H9c2 from the injury induced by A/H treatment.
identified both Syk and Src (zeige SRC Proteine) signaling pathways as ones that participate in Borrelia burgdorferi phagocytosis and the resulting cytokine activation.
These results identify Syk as a critical component of skin inflammation in a mouse model of epidermolysis bullosa acquisita
Syk was identified as the target enzyme most strongly inhibited by water extract of Cordyceps bassiana.
The downmodulation of Syk expression and phosphorylation in intestinal DCs could be important mechanisms through which helminths induce regulatory DCs that limit colitis.
These data suggest that Syk mRNA expression dynamics is closely related to bovine leukemia virus-induced disease.
This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Tyrosine-protein kinase SYK
, tyrosine-protein kinase SYK
, protein-tyrosine kinase