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Cholesterol crystals activate specific cell signalling pathways which drive the production of inflammatory cytokines and degradative enzymes known to contribute to disease initiation and progression and are dependent on activation of Syk and PI3K (zeige PIK3CA Proteine)
Syk-induced signals in bone marrow stromal cell lines are mediated by phospholipase C (zeige PLC Proteine) gamma1 (PLCgamma1 (zeige PLCG1 Proteine)) in osteogenesis and PLCgamma2 (zeige PLCG2 Proteine) in adipogenesis.
AKT (zeige AKT1 Proteine) and 14-3-3 (zeige YWHAQ Proteine) proteins down-regulate the activity of several BCR (zeige BCR Proteine)-associated components, including BTK (zeige BTK Proteine), BLNK (zeige BLNK Proteine) and SYK and also inhibit SYK's interaction with Importin 7 (zeige IPO7 Proteine)
Expression of SYK and its splice variants was significantly lower in tumors with MSI, and in KRAS wild type, BRAF mutant and PTEN mutant tumors
combined use of butyrate and highly specific Syk inhibitor BAY61-3606 does not enhance differentiation and apoptosis of colonocytes. Instead, BAY completely abolishes butyrate-induced differentiation and apoptosis in a Syk- and ERK1/2-dependent manner.
Study demonstrates that redundant complexes formed by the mutant SYK(Y3F) protein allow it to maintain signaling to receptor-proximal interaction partners, resulting in proper initiation of BCR (zeige BCR Proteine)-proximal signals.
The study identified the criteria for the design of binders that specifically address either the Syk or the Zap-70 (zeige ZAP70 Proteine) Tandem Src (zeige SRC Proteine) Homology 2 Domains, tSH2. While Syk tSH2 has a rather broad substrate scope, ZAP-70 (zeige ZAP70 Proteine) tSH2 required a proximal arrangement of the phosphotyrosine ligands in defined strand orientation.
SYK mediates the actions of EPO (zeige EPO Proteine) and GM-CSF (zeige CSF2 Proteine) and coordinates with TGF-beta (zeige TGFB1 Proteine) in erythropoiesis.
study demonstrates that high SYK expression is a common feature of CD21 (zeige CR2 Proteine)(low) B cells independent of the underlying disorder, and that this high expression is sufficient to drive constitutive phosphorylation of SYK and its immediate targets Bruton's tyrosine kinase (zeige BTK Proteine) and phospholipase Cgamma2
IgG (mAb)-opsonized, inactivated Francisella tularensis LVS enhances macrophage and dendritic cell IL-1beta (zeige IL1B Proteine) responses in a TLR2- and FcgammaR-dependent fashion. FcgammaR-mediated Syk activation leads to NLRP3 (zeige NLRP3 Proteine) inflammasome-dependent IL-1beta (zeige IL1B Proteine) production in macrophages.
SYK could induce HO-1 (zeige HMOX1 Proteine) expression by regulating the Akt (zeige AKT1 Proteine) phosphorylation level in H9c2 with A/H injury, protecting H9c2 from the injury induced by A/H treatment.
identified both Syk and Src (zeige SRC Proteine) signaling pathways as ones that participate in Borrelia burgdorferi phagocytosis and the resulting cytokine activation.
These results identify Syk as a critical component of skin inflammation in a mouse model of epidermolysis bullosa acquisita
Syk was identified as the target enzyme most strongly inhibited by water extract of Cordyceps bassiana.
The downmodulation of Syk expression and phosphorylation in intestinal DCs could be important mechanisms through which helminths induce regulatory DCs that limit colitis.
ephrin B3 (zeige EFNB3 Proteine)/EphB2 (zeige EPHB2 Proteine) are obvious candidates for driving the Syk-dependent repulsive response.
The effect of Smad4 (zeige SMAD4 Proteine) was at least partially mediated by the downstream effectors Syk and ROCK2 (zeige ROCK2 Proteine) transcription in megakaryocytes.
These data suggest that Syk mRNA expression dynamics is closely related to bovine leukemia virus-induced disease.
This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Tyrosine-protein kinase SYK
, tyrosine-protein kinase SYK
, protein-tyrosine kinase