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Human NR4A3 Protein expressed in Wheat germ - ABIN1312985
Medunjanin, Daniel, Weinert, Dutzmann, Burgbacher, Brecht, Bruemmer, Kähne, Naumann, Sedding, Zuschratter, Braun-Dullaeus: DNA-dependent protein kinase (DNA-PK) permits vascular smooth muscle cell proliferation through phosphorylation of the orphan nuclear receptor NOR1. in Cardiovascular research 2015
aberrant JAK (zeige JAK3 Proteine)/STAT3 (zeige STAT3 Proteine) signaling epigenetically silences a potential tumor suppressor, NR4A3, in gastric cancer, plausibly representing a reliable biomarker for gastric cancer prognosis
NOR1 activates HSCs and contributes to liver fibrosis in vitro and this effect was achieved through the activation of the Wnt/betacatenin pathway.
In the 3 cases of the primary extraskeletal myxoid chondrosarcoma (EMC) of bone we found the most frequent and specific chromosomal translocation t(9:22) EWSR1 (zeige EWSR1 Proteine)-NR4A3 of the extraskeletal counterpart.
Results indicate that NOR-1 regulate SMPX (zeige SMPX Proteine) in human muscle cells and acts as a muscle regulatory factor to promote myotube differentiation.
NR4A sub-family of nuclear orphan receptors (Nor-1, Nurr-1 (zeige NR4A2 Proteine) and Nur-77 (zeige NR4A1 Proteine)) may have a role in trophoblastic cell differentiation.
VTN (zeige VTN Proteine) levels were increased in cell supernatants from vascular smooth muscle cells that overexpress NOR-1
NR4A2 (zeige NR4A2 Proteine) and NR4A3 are components of a downstream transcriptional response to PKA activation in the neutrophil, and that they positively regulate neutrophil survival and homeostasis.
NOR1 suppresses cancer stem-like cell properties in nasopharyngeal carcinoma cells by inhibiting the AKT (zeige AKT1 Proteine)-GSK-3beta-Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine)-ALDH1A1 (zeige ALDH1A1 Proteine) signaling circuit.
Transcript analysis of four different aggressive lymphoma cell lines overexpressing either NR4A3 or NR4A1 (zeige NR4A1 Proteine) revealed that apoptosis was driven similarly by induction of BAK (zeige BAK1 Proteine), Puma (zeige BBC3 Proteine), BIK (zeige BIK Proteine), BIM (zeige BCL2L11 Proteine), BID (zeige BID Proteine), and Trail. Overall, our results showed that NR4A3 possesses robust tumor suppressor functions of similar impact to NR4A1 (zeige NR4A1 Proteine) in aggressive lymphomas
Study found a marked down-regulated gene expression of the NR4A subfamily (NR4A1 (zeige NR4A1 Proteine), NR4A2 (zeige NR4A2 Proteine), and NR4A3) obtained from Parkinson's disease patients, but only a NR4A1 (zeige NR4A1 Proteine) decrease in Alzheimer's disease patients compared to healthy controls. This study reports that the entire NR4A subfamily and not only NR4A2 (zeige NR4A2 Proteine) could be systemically involved in Parkinson's disease.
NOR1 deletion induced differential inflammatory gene transcription in macrophages but did not influence abdominal aortic aneurysm formation.
Nor-1 expression drives multiple physiological changes/pathways that are critical to the beneficial responses of muscle to exercise.
these results show that NR4A3 is involved in TLR-mediated activation and gene expression of dendritic cells
NR4A3 plays an important role in the regulation of CD103 (zeige ITGAE Proteine)+ mDCs by regulating CCR7 (zeige CCR7 Proteine)-dependent cell migration.
Study shows that NOR-1 can transduce survival signals in neuronal cells responsible for hypoxiainduced apoptotic insults through activation of a CREB (zeige CREB1 Proteine)/cIAP2 (zeige BIRC3 Proteine)-dependent mechanism
Promoting Liver X receptor-alpha (zeige NR1H3 Proteine) expression inhibits lipopolysaccharide induced inflammation in Kupffer cells through elevating NOR-1 expression.
Identified Nur77 (zeige NR4A1 Proteine)/Nor1 as novel regulators of thrombomodulin (zeige THBD Proteine) expression and function in vascular endothelial cells.
Nr4a3 factor plays crucial role regulatory T cells, mediating the two defining characteristics of regulatory T cells: stability of cell lineage and immunosuppressive functions.
Studies demonstrate that NOR1 deletion in hematopoietic stem cells accelerates atherosclerosis formation by promoting myelopoiesis in the stem cell compartment and by inducing local proatherogenic activities in the macrophage.
Our data support a role for NOR-1 as a negative modulator of the acute response elicited by pro-inflammatory stimuli in the vasculature.
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcriptional activator. The protein can efficiently bind the NGFI-B Response Element (NBRE). Three different versions of extraskeletal myxoid chondrosarcomas (EMCs) are the result of reciprocal translocations between this gene and other genes. The translocation breakpoints are associated with Nuclear Receptor Subfamily 4, Group A, Member 3 (on chromosome 9) and either Ewing Sarcome Breakpoint Region 1 (on chromosome 22), RNA Polymerase II, TATA Box-Binding Protein-Associated Factor, 68-KD (on chromosome 17), or Transcription factor 12 (on chromosome 15). Multiple transcript variants encoding different isoforms have been found for this gene.
chondrosarcoma, extraskeletal myxoid, fused to EWS
, mitogen-induced nuclear orphan receptor
, neuron-derived orphan receptor 1
, nuclear hormone receptor NOR-1
, nuclear receptor subfamily 4 group A member 3
, translocated in extraskeletal chondrosarcoma
, neural orphan receptor 1
, orphan nuclear receptor TEC
, neuron-derived orphan receptor 1/2
, nuclear hormone receptor NOR-1/NOR-2
, nuclear receptor subfamily 4, group A, member 3
, neural orphan nuclear receptor NOR1