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Inhibition of NR4A1 in stromal cells increased the TGF-beta1 (zeige TGFB1 Proteine)-dependent elevated expression of fibrotic markers, and loss of NR4A1 stimulated fibrogenesis in mice with endometriosis.
NR4A1 knockdown partly decreased surface NR2B (zeige GRIN2B Proteine) by promoting NR2B (zeige GRIN2B Proteine) internalization.
Data show that SUMOylation is critical in controlling NR4A1 function in inflammatory cytokine signaling and controlling macrophage cell death.
our findings suggest that hypoxia-induced down-regulation of TR3 might play an important role for hypoxia-induced apoptosis resistance in NSCLC.
Nur77 suppresses CD4 (zeige CD4 Proteine)(+) T cell proliferation and uncover a suppressive role for Irf4 (zeige IRF4 Proteine) in TH2 polarization; halving Irf4 (zeige IRF4 Proteine) gene-dosage leads to increases in GATA3 (zeige GATA3 Proteine)(+) and IL-4 (zeige IL4 Proteine)(+) cells.
our data demonstrated that NR4A1 protein physically associates with the WT1 (zeige WT1 Proteine) promoter, and enhanced WT1 (zeige WT1 Proteine) promoter transactivation and knockdown of WT1 (zeige WT1 Proteine) in MIN6 cells induced apoptosis. These findings suggest that NR4A1 protects pancreatic beta-cells against H2O2 mediated apoptosis by up-regulating WT1 (zeige WT1 Proteine) expression.
NR4A modulates the decidualization of hESCs by upregulating prolactin (PRL (zeige PRL Proteine)) and insulin-like growth factor binding protein-1 (IGFBP-1 (zeige IGFBPI Proteine)) expression and transformation in vitro.
DNMT1 (zeige DNMT1 Proteine) causes NR4A1 DNA hypermethylation and blocks insulin (zeige INS Proteine) signaling in an Chinese patients with type 2 diabetes
Data show that nuclear receptor 4A1 (NR4A1) knockdown and the C-DIM/NR4A1 antagonists were comparable as inhibitors of NR4A1-dependent genes/pathways.
mRNAs expression and methylation pattern of RARB, NR4A1 and HSD3B2 genes in human adrenal tissues (HAT) and in pediatric virilizing adrenocortical tumors (VAT) were analyzed.
Identify the orphan nuclear receptor NR4A1 as a potential early response gene in FGF2 signaling and regulation of sprouty in bovine ovarian granulosa cells.
we found that either knockdown of Nr4a1 or 3, 3'- Diindolylmethane (DIM), an Nr4a1 antagonist, were able to rescue the effects of SNRPN (zeige SNRPN Proteine) knockdown on neurite outgrowth of embryonic cortical neurons, providing the potential therapeutic methods for SNRPN (zeige SNRPN Proteine) deletion disorders. We thus concluded that maintaining the proper level of SNRPN (zeige SNRPN Proteine) is critical in cortical neurodevelopment.
new insights into the understanding the mechanisms of the effects of Nur77 on LPS (zeige TLR4 Proteine)-activated microglia
These results suggest that berberine-induced activation of AMPK (zeige PRKAA1 Proteine) may contribute to hepatic FGF21 (zeige FGF21 Proteine) expression via NUR77.
we found that KLF6 (zeige KLF6 Proteine) transcriptionally cooperates with NUR77 and SF1 (zeige SF1 Proteine)
Ca(2 (zeige CA2 Proteine)+) signaling pathway increases Nr4a1 expression in MA-10 Leydig cells, at least in part, by enhancing the recruitment of coactivator most likely through the MEF2 (zeige MEF2C Proteine), AP1 (zeige JUN Proteine), and CREB (zeige CREB1 Proteine) transcription factors thus demonstrating an important interplay between the Ca(2 (zeige CA2 Proteine)+) and cAMP pathways in regulating Nr4a1 expression.
additional loss of Nur77 in the absence of Bim (zeige BCL2L11 Proteine) led to diabetes induction, suggesting that Nur77 promotes tolerance in this context. Together, these data reveal novel nondeletional roles for Nur77 that differ between T cell subsets and have implications for self-tolerance.
current data identify Nr4a1 as regulator of microglia activation and potentially new target for the treatment of inflammatory CNS diseases such as multiple sclerosis.
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.
, TR3 orphan receptor
, early response protein NAK1
, growth factor-inducible nuclear protein N10
, hormone receptor
, nerve growth factor IB nuclear receptor variant 1
, nuclear hormone receptor NUR/77
, nuclear receptor subfamily 4 group A member 1
, orphan nuclear receptor HMR
, orphan nuclear receptor TR3
, steroid receptor TR3
, testicular receptor 3
, orphan nuclear receptor NGFI-B
, nuclear protein N10
, Orphan nuclear receptor HMR
, immediate early gene transcription factor NGFI-B
, nerve growth factor induced protein I-B
, nerve growth factor-induced protein I-B