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Nur77 suppresses CD4 (zeige CD4 Proteine)(+) T cell proliferation and uncover a suppressive role for Irf4 (zeige IRF4 Proteine) in TH2 polarization; halving Irf4 (zeige IRF4 Proteine) gene-dosage leads to increases in GATA3 (zeige GATA3 Proteine)(+) and IL-4 (zeige IL4 Proteine)(+) cells.
our data demonstrated that NR4A1 protein physically associates with the WT1 (zeige WT1 Proteine) promoter, and enhanced WT1 (zeige WT1 Proteine) promoter transactivation and knockdown of WT1 (zeige WT1 Proteine) in MIN6 cells induced apoptosis. These findings suggest that NR4A1 protects pancreatic beta-cells against H2O2 mediated apoptosis by up-regulating WT1 (zeige WT1 Proteine) expression.
NR4A modulates the decidualization of hESCs by upregulating prolactin (PRL (zeige PRL Proteine)) and insulin-like growth factor binding protein-1 (IGFBP-1 (zeige IGFBPI Proteine)) expression and transformation in vitro.
DNMT1 (zeige DNMT1 Proteine) causes NR4A1 DNA hypermethylation and blocks insulin (zeige INS Proteine) signaling in an Chinese patients with type 2 diabetes
Data show that nuclear receptor 4A1 (NR4A1) knockdown and the C-DIM/NR4A1 antagonists were comparable as inhibitors of NR4A1-dependent genes/pathways.
mRNAs expression and methylation pattern of RARB, NR4A1 and HSD3B2 genes in human adrenal tissues (HAT) and in pediatric virilizing adrenocortical tumors (VAT) were analyzed.
NR4A sub-family of nuclear orphan receptors (Nor-1 (zeige NR4A3 Proteine), Nurr-1 (zeige NR4A2 Proteine) and Nur-77) may have a role in trophoblastic cell differentiation.
beta1-integrin expression is regulated in pancreatic and colon cancer cells by the pro-oncogenic orphan nuclear receptor 4A1
Inhibition of NR4A1-mediated transcriptional activity was involved in the anticancer effects of fangchinoline; fangchinoline represents a novel class of mechanism-based anticancer agents targeting NR4A1 that is overexpressed in pancreatic cancer.
Transcript analysis of four different aggressive lymphoma cell lines overexpressing either NR4A3 (zeige NR4A3 Proteine) or NR4A1 revealed that apoptosis was driven similarly by induction of BAK (zeige BAK1 Proteine), Puma (zeige BBC3 Proteine), BIK (zeige BIK Proteine), BIM (zeige BCL2L11 Proteine), BID (zeige BID Proteine), and Trail. Overall, our results showed that NR4A3 (zeige NR4A3 Proteine) possesses robust tumor suppressor functions of similar impact to NR4A1 in aggressive lymphomas
Identify the orphan nuclear receptor NR4A1 as a potential early response gene in FGF2 signaling and regulation of sprouty in bovine ovarian granulosa cells.
These results suggest that berberine-induced activation of AMPK (zeige PRKAA1 Proteine) may contribute to hepatic FGF21 (zeige FGF21 Proteine) expression via NUR77.
we found that KLF6 (zeige KLF6 Proteine) transcriptionally cooperates with NUR77 and SF1 (zeige SF1 Proteine)
Ca(2 (zeige CA2 Proteine)+) signaling pathway increases Nr4a1 expression in MA-10 Leydig cells, at least in part, by enhancing the recruitment of coactivator most likely through the MEF2 (zeige MEF2C Proteine), AP1 (zeige JUN Proteine), and CREB (zeige CREB1 Proteine) transcription factors thus demonstrating an important interplay between the Ca(2 (zeige CA2 Proteine)+) and cAMP pathways in regulating Nr4a1 expression.
additional loss of Nur77 in the absence of Bim (zeige BCL2L11 Proteine) led to diabetes induction, suggesting that Nur77 promotes tolerance in this context. Together, these data reveal novel nondeletional roles for Nur77 that differ between T cell subsets and have implications for self-tolerance.
current data identify Nr4a1 as regulator of microglia activation and potentially new target for the treatment of inflammatory CNS diseases such as multiple sclerosis.
Celastrol promotes Nur77 migration from the nucleus to mitochondria, where it is ubiquitinated by TRAF2 (zeige TRAF2 Proteine). Ubiquitinated Nur77 then interacts with p62/SQSTM1 (zeige SQSTM1 Proteine), leading to autophagy of dysfunctional mitochondria and alleviation of inflammation.
New transcript variants encode for NUR77 protein isoforms which are significantly smaller in size due to lack of transactivation domain and a part of DNA binding domain. Western blot analysis using NUR77 specific antibody confirmed the existence of these smaller variants in mouse.
Nur77 deficiency compromises myofiber growth, but not the regenerative capacity of myogenic progenitor cells.
Using Nr4a1 transgenic mice, electrically evoked dopamine release was shown to differ between the striosome and matrix compartments of the corpus striatum in a regionally-distinct manner.
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.
, TR3 orphan receptor
, early response protein NAK1
, growth factor-inducible nuclear protein N10
, hormone receptor
, nerve growth factor IB nuclear receptor variant 1
, nuclear hormone receptor NUR/77
, nuclear receptor subfamily 4 group A member 1
, orphan nuclear receptor HMR
, orphan nuclear receptor TR3
, steroid receptor TR3
, testicular receptor 3
, orphan nuclear receptor NGFI-B
, nuclear protein N10
, Orphan nuclear receptor HMR
, immediate early gene transcription factor NGFI-B
, nerve growth factor induced protein I-B
, nerve growth factor-induced protein I-B