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we show here that the BCR (zeige BCR Proteine)/BTK (zeige BTK Proteine) target gene NR4A1 is a potential oncogene (zeige RAB1A Proteine) in mantle cell lymphoma
this study confirmed that NR4A1 sensitizes gastric cancer cells to TNFalpha (zeige TNF Proteine)-induced apoptosis through the inhibition of JNK (zeige MAPK8 Proteine)/Parkin (zeige PARK2 Proteine)-dependent mitophagy.
Inhibition of NR4A1 in stromal cells increased the TGF-beta1 (zeige TGFB1 Proteine)-dependent elevated expression of fibrotic markers, and loss of NR4A1 stimulated fibrogenesis in mice with endometriosis.
NR4A1 knockdown partly decreased surface NR2B (zeige GRIN2B Proteine) by promoting NR2B (zeige GRIN2B Proteine) internalization.
Data show that SUMOylation is critical in controlling NR4A1 function in inflammatory cytokine signaling and controlling macrophage cell death.
our findings suggest that hypoxia-induced down-regulation of TR3 might play an important role for hypoxia-induced apoptosis resistance in NSCLC.
Nur77 suppresses CD4 (zeige CD4 Proteine)(+) T cell proliferation and uncover a suppressive role for Irf4 (zeige IRF4 Proteine) in TH2 polarization; halving Irf4 (zeige IRF4 Proteine) gene-dosage leads to increases in GATA3 (zeige GATA3 Proteine)(+) and IL-4 (zeige IL4 Proteine)(+) cells.
our data demonstrated that NR4A1 protein physically associates with the WT1 (zeige WT1 Proteine) promoter, and enhanced WT1 (zeige WT1 Proteine) promoter transactivation and knockdown of WT1 (zeige WT1 Proteine) in MIN6 cells induced apoptosis. These findings suggest that NR4A1 protects pancreatic beta-cells against H2O2 mediated apoptosis by up-regulating WT1 (zeige WT1 Proteine) expression.
NR4A modulates the decidualization of hESCs by upregulating prolactin (PRL (zeige PRL Proteine)) and insulin-like growth factor binding protein-1 (IGFBP-1 (zeige IGFBPI Proteine)) expression and transformation in vitro.
DNMT1 (zeige DNMT1 Proteine) causes NR4A1 DNA hypermethylation and blocks insulin (zeige INS Proteine) signaling in an Chinese patients with type 2 diabetes
Identify the orphan nuclear receptor NR4A1 as a potential early response gene in FGF2 signaling and regulation of sprouty in bovine ovarian granulosa cells.
Cd36 (zeige CD36 Proteine) deficiency led to reduced expression of phagocytosis receptor Mertk (zeige MERTK Proteine) and nuclear receptor Nr4a1 in cardiac macrophages, the latter previously shown to be required for phagocyte survival.
identify Nur77 as a transcriptional regulator of T cell metabolism, which elevates the threshold for T cell activation and confers protection in different T cell-mediated inflammatory diseases.
The data show that NR4A1 expression by multipotent progenitors of the spleen limits erythropoiesis and megakaryopoeisis, permitting development to other myeloid lineages. This effect is specific to the spleen, revealing a unique molecular pathway that regulates myeloid bias in an extramedullary niche.
NR4A1 knockdown interrupted the Mff (zeige MFF Proteine)-related mitochondrial fission and recused Parkin (zeige PARK2 Proteine)-mediated mitophagy, reducing the hyperglycemia-mediated mitochondrial damage and thus improving renal function.
we found that either knockdown of Nr4a1 or 3, 3'- Diindolylmethane (DIM), an Nr4a1 antagonist, were able to rescue the effects of SNRPN (zeige SNRPN Proteine) knockdown on neurite outgrowth of embryonic cortical neurons, providing the potential therapeutic methods for SNRPN (zeige SNRPN Proteine) deletion disorders. We thus concluded that maintaining the proper level of SNRPN (zeige SNRPN Proteine) is critical in cortical neurodevelopment.
new insights into the understanding the mechanisms of the effects of Nur77 on LPS (zeige TLR4 Proteine)-activated microglia
These results suggest that berberine-induced activation of AMPK (zeige PRKAA1 Proteine) may contribute to hepatic FGF21 (zeige FGF21 Proteine) expression via NUR77.
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.
, TR3 orphan receptor
, early response protein NAK1
, growth factor-inducible nuclear protein N10
, hormone receptor
, nerve growth factor IB nuclear receptor variant 1
, nuclear hormone receptor NUR/77
, nuclear receptor subfamily 4 group A member 1
, orphan nuclear receptor HMR
, orphan nuclear receptor TR3
, steroid receptor TR3
, testicular receptor 3
, orphan nuclear receptor NGFI-B
, nuclear protein N10
, Orphan nuclear receptor HMR
, immediate early gene transcription factor NGFI-B
, nerve growth factor induced protein I-B
, nerve growth factor-induced protein I-B