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anti-Human NR4A1 Antikörper:
anti-Mouse (Murine) NR4A1 Antikörper:
anti-Rat (Rattus) NR4A1 Antikörper:
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Human Polyclonal NR4A1 Primary Antibody für ChIP, ICC - ABIN252681
Nakai, Kartha, Sakurai, Toback, DeGroot: A human early response gene homologous to murine nur77 and rat NGFI-B, and related to the nuclear receptor superfamily. in Molecular endocrinology (Baltimore, Md.) 1991
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Mouse (Murine) Monoclonal NR4A1 Primary Antibody für WB - ABIN967395
Davis, Hazel, Chen, Blenis, Lau: Functional domains and phosphorylation of the orphan receptor Nur77. in Molecular endocrinology (Baltimore, Md.) 1993
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Cow (Bovine) Polyclonal NR4A1 Primary Antibody für IHC, WB - ABIN2782269
Smith, Luk, Newton, Roberts, Sturm, Muscat: Melanocortin-1 receptor signaling markedly induces the expression of the NR4A nuclear receptor subgroup in melanocytic cells. in The Journal of biological chemistry 2008
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Human Polyclonal NR4A1 Primary Antibody für ELISA, IHC (p) - ABIN188670
Kiss, Oskolás, Tóth, Bouillet, Tóth, Fülöp, Scholtz, Ledent, Fésüs, Szondy: Adenosine A2A receptor-mediated cell death of mouse thymocytes involves adenylate cyclase and Bim and is negatively regulated by Nur77. in European journal of immunology 2006
Cow (Bovine) Polyclonal NR4A1 Primary Antibody für IHC, WB - ABIN2777511
Lu, Suzuki, Yoshikawa, Murakami, Miki, Moriya, Bassett, Rainey, Hayashi, Sasano: Nur-related factor 1 and nerve growth factor-induced clone B in human adrenal cortex and its disorders. in The Journal of clinical endocrinology and metabolism 2004
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NR4A modulates the decidualization of hESCs by upregulating prolactin (PRL (zeige PRL Antikörper)) and insulin-like growth factor binding protein-1 (IGFBP-1 (zeige IGFBPI Antikörper)) expression and transformation in vitro.
DNMT1 (zeige DNMT1 Antikörper) causes NR4A1 DNA hypermethylation and blocks insulin (zeige INS Antikörper) signaling in an Chinese patients with type 2 diabetes
Data show that nuclear receptor 4A1 (NR4A1) knockdown and the C-DIM/NR4A1 antagonists were comparable as inhibitors of NR4A1-dependent genes/pathways.
mRNAs expression and methylation pattern of RARB (zeige RARB Antikörper), NR4A1 and HSD3B2 (zeige HSD3B2 Antikörper) genes in human adrenal tissues (HAT (zeige MGEA5 Antikörper)) and in pediatric virilizing adrenocortical tumors (VAT) were analyzed.
NR4A sub-family of nuclear orphan receptors (Nor-1 (zeige NR4A3 Antikörper), Nurr-1 (zeige NR4A2 Antikörper) and Nur-77) may have a role in trophoblastic cell differentiation.
beta1-integrin expression is regulated in pancreatic and colon cancer cells by the pro-oncogenic orphan nuclear receptor 4A1
Inhibition of NR4A1-mediated transcriptional activity was involved in the anticancer effects of fangchinoline; fangchinoline represents a novel class of mechanism-based anticancer agents targeting NR4A1 that is overexpressed in pancreatic cancer.
Transcript analysis of four different aggressive lymphoma cell lines overexpressing either NR4A3 (zeige NR4A3 Antikörper) or NR4A1 revealed that apoptosis was driven similarly by induction of BAK (zeige BAK1 Antikörper), Puma (zeige BBC3 Antikörper), BIK (zeige BIK Antikörper), BIM (zeige BCL2L11 Antikörper), BID (zeige BID Antikörper), and Trail. Overall, our results showed that NR4A3 (zeige NR4A3 Antikörper) possesses robust tumor suppressor functions of similar impact to NR4A1 in aggressive lymphomas
NR4A1 expression is specific to a quiescent subset of T-cells.
we demonstrate that endogenous Nur77 protein expression can serve as a reporter of T-cell receptor and B-cell receptor specific signaling in human peripheral blood mononuclear cells.
Identify the orphan nuclear receptor NR4A1 as a potential early response gene in FGF2 signaling and regulation of sprouty in bovine ovarian granulosa cells.
These results suggest that berberine-induced activation of AMPK (zeige PRKAA1 Antikörper) may contribute to hepatic FGF21 (zeige FGF21 Antikörper) expression via NUR77.
we found that KLF6 (zeige KLF6 Antikörper) transcriptionally cooperates with NUR77 and SF1 (zeige SF1 Antikörper)
Ca(2 (zeige CA2 Antikörper)+) signaling pathway increases Nr4a1 expression in MA-10 Leydig cells, at least in part, by enhancing the recruitment of coactivator most likely through the MEF2 (zeige MEF2C Antikörper), AP1 (zeige JUN Antikörper), and CREB (zeige CREB1 Antikörper) transcription factors thus demonstrating an important interplay between the Ca(2 (zeige CA2 Antikörper)+) and cAMP pathways in regulating Nr4a1 expression.
additional loss of Nur77 in the absence of Bim (zeige BCL2L11 Antikörper) led to diabetes induction, suggesting that Nur77 promotes tolerance in this context. Together, these data reveal novel nondeletional roles for Nur77 that differ between T cell subsets and have implications for self-tolerance.
current data identify Nr4a1 as regulator of microglia activation and potentially new target for the treatment of inflammatory CNS diseases such as multiple sclerosis.
Celastrol promotes Nur77 migration from the nucleus to mitochondria, where it is ubiquitinated by TRAF2 (zeige TRAF2 Antikörper). Ubiquitinated Nur77 then interacts with p62/SQSTM1 (zeige SQSTM1 Antikörper), leading to autophagy of dysfunctional mitochondria and alleviation of inflammation.
New transcript variants encode for NUR77 protein isoforms which are significantly smaller in size due to lack of transactivation domain and a part of DNA binding domain. Western blot analysis using NUR77 specific antibody confirmed the existence of these smaller variants in mouse.
Nur77 deficiency compromises myofiber growth, but not the regenerative capacity of myogenic progenitor cells.
Using Nr4a1 transgenic mice, electrically evoked dopamine release was shown to differ between the striosome and matrix compartments of the corpus striatum in a regionally-distinct manner.
Nur77 was found to be an important modulator in microglia function and attenuated pro-inflammatory mediator production.
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.
, TR3 orphan receptor
, early response protein NAK1
, growth factor-inducible nuclear protein N10
, hormone receptor
, nerve growth factor IB nuclear receptor variant 1
, nuclear hormone receptor NUR/77
, nuclear receptor subfamily 4 group A member 1
, orphan nuclear receptor HMR
, orphan nuclear receptor TR3
, steroid receptor TR3
, testicular receptor 3
, orphan nuclear receptor NGFI-B
, nuclear protein N10
, Orphan nuclear receptor HMR
, immediate early gene transcription factor NGFI-B
, nerve growth factor induced protein I-B
, nerve growth factor-induced protein I-B