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Using immunohistochemistry, we validated that MS4A2 (zeige MS4A1 Proteine), the beta subunit (zeige POLG Proteine) of the IgE receptor expressed on mast cells, is a favorable prognostic indicator and show that MS4A2 (zeige MS4A1 Proteine) gene expression is an independent prognostic marker for early-stage lung cancer patient survival.
in patients with allergic rhinitis without asthma, the FCER1B rs569108 and rs512555 polymorphisms are associated with increased risk of developing allergic rhinitis and with lower IgE levels.
study found a difference in the frequencies of genotypes of FcvarepsilonRIbeta subunit int 2 (zeige FGF3 Proteine) in allergic rhinitis patients and controls. The FcvarepsilonRIbeta subunit int 2 (zeige FGF3 Proteine) gene polymorphism was found to be associated with allergic rhinitis in the Polish cohort
MS4A2 (zeige MS4A1 Proteine) was differentially expressed between Fibromyalgia patients and healthy controls.
FcepsilonRIbeta -109C/T and IFN-gamma (zeige IFNG Proteine) 874T/A polymorphisms may be influencing factors for asthma in the Asian population
The results explain how initial membrane interactions of clustered IgE-Fcepsilon RI complexes lead to downstream cellular responses.
Data indicated that the MS4A2 (zeige MS4A1 Proteine) gene E237G variant may be a risk factor for developing atopic asthma and the promoter -109T allele is a potential risk factor of asthma in Asians.
Cytoplasmic FcepsilonRIbeta, which is not co-localized with FcepsilonRIalpha, may function as a negative regulator, as it can capture important signalling molecules such as Lyn (zeige LYN Proteine).
t-FcepsilonRIbeta mediates Ca2 (zeige CA2 Proteine)+ -dependent microtubule formation, which promotes degranulation and cytokine release.
The interaction between Lyn (zeige LYN Proteine) and FcepsilonRIbeta is indispensable for FcepsilonRI (zeige FCER1G Proteine)-mediated human mast cell activation.
Analysis of the conformation and thermal stability of the high-affinity IgE Fc receptor beta chain polymorphic proteins has been presented.
chemotaxis toward antigen is controlled in mast cells by a cross-talk among FcepsilonRI (zeige FCER1A Proteine), tetraspanin CD9 (zeige CD9 Proteine), transmembrane adaptor proteins NTAL (zeige LAT2 Proteine) and LAT (zeige LAT Proteine), and cytoskeleton-regulatory proteins of the ERM (zeige ETV5 Proteine) family
Findings indicate that SLP-76 (zeige LCP2 Proteine) is an essential signaling component for basophil activation downstream of both FcepsilonRI (zeige FCER1A Proteine) and the IL-3 (zeige IL-3 Proteine) receptor.
FcRbeta is a critical element in mast cell synergistic degranulation response through FcepsilonRI (zeige FCER1A Proteine) & adenosine receptors. PI3K-signaling through FcRbeta-ITAM is a crucial participant in augmentation of FcepsilonRI (zeige FCER1A Proteine)-mediated degranulation by adenosine.
inhibition of FcepsilonRI (zeige FCER1A Proteine)-dependent mast cell activation can suppress allergic contact dermatitis
Gene expression profiling after stimulation via high-affinity Fcepsilon receptor I (FcepsilonRI (zeige FCER1A Proteine)), showed the transcriptional levels of several CC chemokines were markedly increased.
FcepsilonRIbeta functions to both selectively amplify (degranulation and leukotriene secretion) and dampen (lymphokine (zeige IL2 Proteine)) mast cell effector responses
IgE receptors are expressed on sensory neurons in mice. Immunostaining revealed that the high affinity IgE receptor FcepsilonRI (zeige FCER1A Proteine) was expressed in cultured dorsal root ganglion cells.
FcepsilonRI (zeige FCER1A Proteine) beta-chain regulates calcium uptake in mast cells via the immunoreceptor tyrosine-based activation motif.
IgE signaling suppresses FcepsilonRIbeta expression.
The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of membrane-spanning 4A gene family members. Alternative splicing results in multiple transcript variants encoding distinct proteins. Additional transcript variants have been described but require experimental validation.
Fc fragment of IgE, high affinity I, receptor for; beta polypeptide
, High affinity immunoglobulin epsilon receptor beta-subunit (FcERI) (IgE Fc receptor, beta-subunit) (Fc epsilon receptor I beta-chain)
, high affinity IgE receptor beta subunit
, high affinity immunoglobulin epsilon receptor subunit beta
, igE Fc receptor subunit beta
, immunoglobulin E receptor, high affinity, beta polypeptide
, Fc receptor, IgE, high affinity I, beta polypeptide
, fc epsilon receptor I beta-chain
, membrane-spanning 4-domains, subfamily A, member 1
, IgE Fc receptor subunit beta
, Membrane-spanning 4-domains subfamily A member 1
, Membrane-spanning 4-domains, subfamily A, member 1
, beta polypeptide)
, membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for
, membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)