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Human Polyclonal FRS2 Primary Antibody für IHC, ELISA - ABIN1532103
Sun, Zou, Yang, Morita, Gong, Shiba, Akagawa, Yuan: Inorganic polyphosphates stimulate FGF23 expression through the FGFR pathway. in Biochemical and biophysical research communications 2012
MiR (zeige MLXIP Antikörper)-4653-3p and its target gene FRS2 are may have roles in response of hormone receptor (zeige NR4A1 Antikörper) positive breast cancer patients to tamoxifen
we report for the first time that PKD1 (zeige PKD1 Antikörper) was tightly regulated by androgen at the transcriptional level in prostate cancer cells and was a novel androgen-repressed gene. Further analysis identified FRS2 as a novel mediator of androgen-induced PKD1 (zeige PKD1 Antikörper) repression.
They also demonstrate the potential of overexpressed FRS2alpha as a biomarker for prostate cancer diagnosis, prognosis and response to therapies.
Results identify FRS2 as an oncogene (zeige RAB1A Antikörper) in a subset of high-grade serous ovarian cancers that harbor FRS2 amplifications.
Increased expression of FRS2alpha (and FGFR1 (zeige FGFR1 Antikörper)) was associated with decreased progression-free survival among patients with metastatic renal cell carcinoma (zeige MOK Antikörper) treated with sorafenib.
The signaling complex appears to integrate the input from FGFR (zeige FGFR2 Antikörper) and EphA4 (zeige EPHA4 Antikörper), and release the output signal through FRS2alpha.
These results establish the Frs2alpha-Shp2 complex as the key mediator of FGF signaling in lens development.
The docking protein FRS2alpha is a critical regulator of VEGF (zeige VEGFA Antikörper) receptors signaling.
Patient with pigmentation disorders and vitiligo (zeige MITF Antikörper) show decreased expression of mRNA.
Data indicate that the FGFR (zeige FGFR2 Antikörper)/FRS2 signaling axis was generally activated in about 75% of FRS2-positive high-grade liposarcomas.
Embryonic day 18.5 Six2Frs2alphaKO kidneys were hypoplastic and not cystic, postnatal day (P) 7 mutants had proximal tubular-derived cysts that nearly replaced the renal parenchyma by P21 (zeige D4S234E Antikörper). Mutants had high proximal tubular proliferation rates and interstitial fibrosis, similar to known polycystic kidney disease models.
Fgfr (zeige FGFR2 Antikörper) signaling in nephron progenitors appears to be mediated predominantly by Frs2alpha.
Analysis of a mutant Fgfr1 (zeige FGFR1 Antikörper) allele, unable to bind to the adaptor protein, Frs2/3, indicates that Sox2 (zeige SOX2 Antikörper) maintenance can be regulated by MAP kinase (zeige MAPK1 Antikörper).
data from two models showed that FRS2 played different roles in the regulation of two activity levels of the ERK (zeige EPHB2 Antikörper) pathway components in the epididymis.
Genetic evidence further supports that the formation of an Frs2alpha-Shp2 (zeige PTPN11 Antikörper) complex and its recruitment to FGF receptors are crucial for downstream ERK (zeige EPHB2 Antikörper) signaling in this process.
Frs2alpha enhances fibroblast growth factor-mediated survival and differentiation in lens development.
a novel signaling network containing FRS2, CAP and flotillin-1 (zeige FLOT1 Antikörper)
FRS2alpha-mediated FGF signals suppress premature differentiation of cardiac stem cells through regulating autophagy activity.
The FGF signaling axis activates mTOR (zeige FRAP1 Antikörper) via the FGF receptor (zeige FGFR2 Antikörper) substrate 2alpha (FRS2alpha)-mediated PI3K/Akt (zeige AKT1 Antikörper) pathway, and suppresses autophagy activity in MEFs.
although Fgfr2 (zeige FGFR2 Antikörper) and Frs2alpha have crucial roles in the ureteric lineage, they appear to act separately and additively.
Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3- kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.
fibroblast growth factor receptor substrate 2
, FGFR signalling adaptor
, FGFR substrate 2
, FGFR-signaling adaptor SNT
, suc1-associated neurotrophic factor target 1