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findings identify RNF-121 as an ER-anchored ubiquitin ligase that plays a specific role in the ERAD pathway by linking it to the regulation of the cell adhesion integrin receptors through PAT-3, an RNF-121 substrate.
Over-expression of RNF121 promoted ubiquitination of VEGFR-2 (zeige KDR Proteine), inhibited its maturation . RNF121 knockdown in primary endothelial cells reduced VEGFR-2 (zeige KDR Proteine) ubiquitination and increased its cell surface level.
These results unveil an unexpected role of Golgi Apparatus and reveal RNF121 as a new player involved in the signaling leading to NF-kappaB (zeige NFKB1 Proteine) activation.
This is the first study to demonstrate that RNF121 is a novel regulator of apoptosis and provides a new potential target for cancer therapy
these results indicate that RNF121 participates in the quality control of NaV channels during their synthesis and subsequent transport to the membrane.
The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. Several alternatively spliced transcript variants have been noted for this gene, however, not all are likely to encode viable protein products.
RING finger protein 121