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Findings establish a general function of Grp170 during ERAD and suggest that positioning this client-release factor at the retrotranslocation site may afford a mechanism to couple client release from BiP (zeige GDF10 Proteine) and retrotranslocation.
Data reveal that Grp170 participates in preparing mutant proinsulin (zeige INS Proteine) for degradation while enabling wild-type proinsulin (zeige INS Proteine) escape from the endoplasmic reticulum.
High ORP150 expression is associated with thyroid cancer.
Two NEFs, Grp170 and Sil1 (zeige SIL1 Proteine), trigger toxin release from BiP (zeige GDF10 Proteine) to enable successful retrotranslocation and clarify the fate of the toxin after it disengages from BiP (zeige GDF10 Proteine).
Grp170 induces nucleotide exchange of BiP (zeige GDF10 Proteine) and releases SV40 virus from BiP (zeige GDF10 Proteine), promoting SV40 ER-to-cytosol transport and infection.
HYOU1 also modulates vIL (zeige VIL1 Proteine)-6's ability to induce CCL2 (zeige CCL2 Proteine).
Here we show that Grp170 can bind directly to a variety of incompletely folded protein substrates in the endoplasmic reticulum, and as expected for a bona fide chaperone, it does not interact with folded secretory proteins.
inducible overexpression of ORP150, in ER stress conditions, exerts inhibitory effect on apoptosis and senescence in human breast carcinoma cells but not in normal fibroblasts
Data indicate that Grp170 (Lhs1 ortholog) coprecipitate with alphaENaC (zeige SCNN1A Proteine).
AICAR (zeige ATIC Proteine) infusion enhanced ORP150 expression, resulting in the marked amelioration of hepatic ER stress and apoptosis
The relative increase in ORP150 mRNA observed in hypoxia, compared with normoxia, may support its cytoprotective role in oxygendeprived conditions
These results suggest that although ORP150 is protective against bleomycin-induced lung injury, this protein could stimulate bleomycin-induced pulmonary fibrosis by increasing pulmonary levels of TGF-beta1 (zeige TGFB1 Proteine) and myofibroblasts.
Results reveal a previously unrecognized attribute of Grp170 as a superior DNA-binding chaperone capable of amplifying TLR9 (zeige TLR9 Proteine) activation on pathogen recognition.
Secreted grp170 can bind to and co-transport out of tumour cells a full length tumour antigen that may play a role in the anti-tumour immune response.
Grp170 displays multiple peptide binding domains; the presence of two strong peptide binding regions in such a large protein may facilitate the interactions and assembly of two substate proteins.
demonstrated that expression of ORP150 in developing brain most likely serves a cytoprotective function in Purkinje cells
The 150-kDa oxygen-regulated protein may be cytoprotective against ischemia/reperfusion injury via reduction of endoplasmic reticulum stress and probably also inhibition of apoptosis.
ORP150 exerts cytoprotective effects in renal tubular epithelia subjected to I/R injury and suggest a key role for ER stress in the renal tubular response to acute renal failure
The protein encoded by this gene belongs to the heat shock protein 70 family. This gene uses alternative transcription start sites. A cis-acting segment found in the 5' UTR is involved in stress-dependent induction, resulting in the accumulation of this protein in the endoplasmic reticulum (ER) under hypoxic conditions. The protein encoded by this gene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness. This gene also has an alternative translation initiation site, resulting in a protein that lacks the N-terminal signal peptide. This signal peptide-lacking protein, which is only 3 amino acids shorter than the mature protein in the ER, is thought to have a housekeeping function in the cytosol. In rat, this protein localizes to both the ER by a carboxy-terminal peptide sequence and to mitochondria by an amino-terminal targeting signal.
150 kDa oxygen-regulated protein
, 170 kDa glucose-regulated protein
, glucose-regulated protein 170
, hypoxia up-regulated protein 1
, oxygen regulated protein (150kD)
, 140 kDa Ca(2+)-binding protein
, 150-kDa oxygen regulated protein
, 170 kDa glucose regulated protein GRP170
, calcium binding protein 140
, calcium binding protein, 140 kDa
, hypoxia up-regulated 1
, Hypoxia up-regulated protein 1
, hypoxia up-regulated protein 1-like
, glucose regulated protein, 170 kDa
, oxygen regulated protein, 150 kDa