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PKR (zeige PKLR Proteine) is co-opted by EV-A71 via viral protease 3C-mediated proteolytic activation to facilitate viral replication.
Findings suggest a novel role for PKR (zeige PKLR Proteine) in lung cancer cells as a mediator of radiation resistance possibly through translocation of the protein product to the nucleus.
a novel, positive role for PKR activation and eIF2alpha phosphorylation in human globin mRNA splicing, is reported.
Clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9-mediated ablation of double-stranded RNA (dsRNA)-activated protein kinase (zeige CDK7 Proteine) R (PKR (zeige PKLR Proteine)) restored p53 (zeige TP53 Proteine) responses while boosting hepatitis C virus replication, showing that p53 (zeige TP53 Proteine) inhibition results directly from viral activation of PKR (zeige PKLR Proteine).
Gene silencing studies showed that the suppression of immunoproteasome induction is essentially dependent on protein kinase (zeige CDK7 Proteine) R (PKR (zeige PKLR Proteine)). Indeed, the generation of a strictly immunoproteasome-dependent cytotoxic T lymphocyte epitope was impaired in in vitro processing experiments using isolated 20S proteasomes from HCV-infected cells and was restored by the silencing of PKR (zeige PKLR Proteine) expression.
data provide the first evidence that KSHV ORF57 plays a role in modulating PKR (zeige PKLR Proteine)/eIF2alpha (zeige EIF2A Proteine)/SG axis and enhances virus production during virus lytic infection.
The PKR (zeige PKLR Proteine) is a key constituent of the metaflammasome and interacts directly with several inflammatory kinases, such as inhibitor kappaB (IkappaB) kinase (zeige CHUK Proteine) (IKK (zeige CHUK Proteine)) and c-Jun N-terminal kinase (JNK), insulin receptor substrate 1 (IRS1 (zeige IRS1 Proteine)), and component of the translational machinery such as eIF2alpha (zeige EIF2A Proteine).
infection with New World arenaviruses JUNV and MACV, but not OW LASV, activated PKR (zeige PKLR Proteine), concomitant with elevated phosphorylation of the translation initiation factor (zeige TIF1 Proteine) alpha subunit (zeige POLG Proteine) of eukaryotic initiation factor (zeige EIF4G1 Proteine) 2
The stem-loop of noncoding RNA 886 is structural feature not only critical for inhibiting PKR (zeige PKLR Proteine) autophosphorylation, but also the phosphorylation of its cellular substrate, EIF-2alpha (zeige EIF2S1 Proteine).
Protein kinase (zeige CDK7 Proteine) R (PKR (zeige PKLR Proteine)) was required for induction of stress granules (SGs (zeige FBN1 Proteine)) by mumps virus (MuV) infection and regulated type III IFN (IFN-lambda1) mRNA stability.
PKR activation is an essential part of the molecular switch from adaptation to inflammation in response to hyperosmotic stress.
We therefore concluded that in osteoblasts, P. gingivalis activated PKR, which in turn increased NLRP3 (zeige NLRP3 Proteine) expression by activating NF-kappaB (zeige NFKB1 Proteine). Our results suggest that PKR modulates inflammation by regulating the expression of the NLRP3 (zeige NLRP3 Proteine) inflammasome through the NF-kappaB (zeige NFKB1 Proteine) pathway in periodontal diseases.
identify iNOS (zeige NOS2 Proteine)/NO as an integral component of IFN-beta (zeige IFNB1 Proteine) production in response to dsRNA in hepatocytes in a pathway that involves the coordinated activities of TLR3 (zeige TLR3 Proteine)/Trif (zeige RNF138 Proteine) and PKR
The data predicts that PKR diminishes inflammasome activity by controlling protein translation to repress the induction of factors that are critical for the activity of the cryopyrin (zeige NLRP3 Proteine) inflammasome.
This study provides insight into the molecular pathology of Cornelia de Lange syndrome by establishing a relationship between NIPBL (zeige NIPBL Proteine) and HDAC8 (zeige HDAC8 Proteine) mutations and PKR activation.
Deletion of PKR does not affect HFD-induced obesity, hepatic steatosis or glucose metabolism, and only modestly affects adipose tissue inflammation.
results show that ceramide acts at two distinct levels of the insulin (zeige INS Proteine) signaling pathway (IRS1 (zeige IRS1 Proteine) and Akt (zeige AKT1 Proteine)). PKR, which is induced by both inflammation signals and ceramide, could play a major role in the development of insulin (zeige INS Proteine) resistance in muscle cells.
Data (including data from studies in transgenic/knockout mice) suggest that PACT/RAX (protein activator of protein kinase (zeige CDK7 Proteine) R) functions as negative regulator of PKR/Eif2ak2 (protein kinase (zeige CDK7 Proteine) R) in development of postnatal anterior pituitary tissue.
Data indicate increasing expression of PKR during TNF-a (zeige TNF Proteine)-induced osteoclast formation. Its inhibition prevents TNF-a (zeige TNF Proteine)-induced bone destruction in vivo and can be then considered as new therapeutic target for bone disease.
The authors show that Murine cytomegalovirus m142 and m143 knockout mutants attain organ titers equivalent to those attained by wild-type virus in Pkr knockout mice.
The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene.
double-stranded RNA-activated protein kinase
, interferon-induced, double-stranded RNA-activated protein kinase
, p68 kinase
, P1/eIF-2A protein kinase
, interferon-inducible RNA-dependent protein kinase
, IFN-stimulated dsRNA-activated eIF2-alpha kinase 2
, double-stranded RNA activated protein kinase
, eukaryotic translation initiation factor 2-alpha kinase 2
, double stranded RNA activated protein kinase
, eIF-2A protein kinase 2
, interferon-inducible elF2alpha kinase
, protein kinase, interferon-inducible double stranded RNA dependent
, tyrosine-protein kinase EIF2AK2
, IFN- type I-induced and dsRNA-activated kinase
, IFN-induced and double-stranded RNA-activated kinase
, T-cell viral integration site
, dsRNA-activated kinase
, eIF-2 alpha
, eukaryotic translation initiation factor 2 alpha kinase 2
, protein kinase RNA-activated
, protein kinase, interferon inducible double stranded RNA dependent
, serine/threonine-protein kinase TIK
, Protein kinase, interferon-inducible double stranded RNA dependent