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results support a critical role of ATF6alpha in the establishment and maintenance of cellular senescence in normal human fibroblasts via the up-regulation of a COX2/PGE2 intracrine pathway.
The results demonstrated that high expression of activated ATF6 aggravates ER stressinduced VEC (zeige CDH5 Proteine) apoptosis through the mitochondrial apoptotic pathway. Furthermore, in response to ER stress, ATF6 upregulates the expression of caspase3, caspase9, CHOP (zeige DDIT3 Proteine), cytochrome c (zeige CYCS Proteine) and Bax (zeige BAX Proteine)/Bcl2 (zeige BCL2 Proteine).
Reporters constructed to monitor each mechanism show that phenobarbital-induced endoplasmic reticulum membrane expansion depends on transmembrane domain-induced ATF6
ATF6 plays a distinct role in viral protein stability and the host uses different cleavage strategies, rather than conventional cleavage by generating p50ATF6, to combat viral infection.
Three branches of the Unfolded Protein Response (UPR) have been described, including the activation of the inositol-requiring enzyme 1 (IRE1 (zeige ERN1 Proteine)), the pancreatic ER kinase (PKR (zeige PKLR Proteine))-like ER kinase (PERK (zeige EIF2AK3 Proteine)), and the activating transcription factor 6 (ATF6).
The expression of ASNS (zeige ASNS Proteine) was significantly elevated when ATF6 was over expressed. The expressions of these 2 genes were both decreased in hepatocellular carcinoma (HCC (zeige FAM126A Proteine))patients, and it was more significantly with ASNS (zeige ASNS Proteine). The mRNA levels of ASNS (zeige ASNS Proteine) and ATF6 were positively correlated with each other. rs34050735 was associated with HCC (zeige FAM126A Proteine) in the case-control study and also an independent predictor of overall survival of HCC (zeige FAM126A Proteine) patients.
Human ATF6 mutations interrupt distinct sequential steps of the ATF6 activation mechanism.
Findings indicate a central role for activating transcription factor 6 (ATF6alpha) in the establishment of morphological features of senescence in normal primary fibroblasts.
A novel homozygous c.1691A>G (p.(Asp564Gly)) ATF6 mutation was identified in two siblings with autosomal recessive cone-rod dystrophy.
This review shown that the achromatopsia arising from genetic mutations in Activating Transcription Factor 6 (ATF6).
ATF6alpha deficiency renders myelinating oligodendrocytes sensitive to IFN-gamma-induced (zeige SAMHD1 Proteine) ER stress in the developing CNS; and renders oligodendrocytes vulnerable to inflammation during experimental autoimmune encephalomyelitis. The results presented in this study suggest that ATF6alpha deficiency increases the vulnerability of oligodendrocytes in immune-mediated demyelinating diseases.
DREAM inhibition markedly improves ATF6 processing in the hippocampus and that it might contribute to a delay in memory decline in Huntington (zeige HTT Proteine) mice.
The findings demonstrate reciprocal regulation of the unfolded protein response, including ATF6alpha activation and endoplasmic reticulum expansion, and reduced contractile differentiation in bladder outlet obstruction occurring independently of thrombospondin-4 (zeige THBS4 Proteine), which however is a sensitive indicator of obstruction.
ATF6 is essential for ER stress-mediated SESN2 (zeige SESN2 Proteine) induction.
Forced activation of the ATF6 UPR branch reduced infarct volume and improved functional outcome at 24 h after stroke
However, depletion of XBP1 (zeige XBP1 Proteine) and ATF6, alone or in combination, prevented autophagy induction and significantly enhanced Japanese encephalitis virus-induced cell death.
Deletion of Atf6alpha suppressed inflammation, and ameliorated demyelination after experimental autoimmune encephalomyelitis.
we show that overexpression of the dominant-negative form of ATF6 (dnATF6) increases susceptibility to develop hepatic steatosis in diet-induced insulin (zeige INS Proteine)-resistant mice and fasted mice. Furthermore, hepatic overexpression of the active form of ATF6 promotes hepatic fatty acid oxidation and protects against hepatic steatosis in diet-induced insulin (zeige INS Proteine)-resistant mice.
The present study extends our understanding and provides new insights into the physiological significance of ATF6, a key signal transducer of ER stress, in ovarian granulosa cells.
ATF6 serves as an important role between ER stress and oxidative stress, by decreasing myocardial ischemia/reperfusion damage.
Exposure of endothelial cells to VEGF (zeige VEGFA Proteine), high glucose, or hydrogen peroxide up-regulated the XBP1 (zeige XBP1 Proteine)/IRE1 alpha (zeige ERN1 Proteine) and ATF6 arms of the unfolded protein response compared with untreated cells.
This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis.
activating transcription factor 6
, cyclic AMP-dependent transcription factor ATF-6 alpha-like
, cAMP-dependent transcription factor ATF-6 alpha
, cyclic AMP-dependent transcription factor ATF-6 alpha