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Ectopic overexpression of Bombyx mori Asparagine synthetase (BmASNS) gene effectively inhibited cell growth in silkworm cells, whereas its overexpression could rescue cell growth upon amino acid deprivation treatment.
Asns is involved in the regulation of plasma glucose levels.
basal ASNS expression at protein levels was significantly correlated with sensitivity to combined treatment. These results provide mechanistic insights into the role of GCN2 in the amino acid response and a rationale for further investigation of GCN2 inhibitors for the treatment of cancer.
The expression of ASNS was significantly elevated when ATF6 (zeige ATF6 Proteine) was over expressed. The expressions of these 2 genes were both decreased in hepatocellular carcinoma (HCC (zeige FAM126A Proteine))patients, and it was more significantly with ASNS. The mRNA levels of ASNS and ATF6 (zeige ATF6 Proteine) were positively correlated with each other. rs34050735 was associated with HCC (zeige FAM126A Proteine) in the case-control study and also an independent predictor of overall survival of HCC (zeige FAM126A Proteine) patients.
our study demonstrated that ASNS had an important role in the growth of human lung cancer cells by inhibiting the proliferation and arresting cell cycle of lung cancer cells
review of ASNS function, structure, mutations and roles in genetic disease and asparaginase drug resistance
Transient knockdown of ASNS inhibited cell proliferation and colony formation in AGS (zeige JAG1 Proteine) and MKN-45 cells. Stable knockdown of ASNS conferred sensitivity to cisplatin in these cells. Depletion of ASNS and cisplatin treatment exerted synergistic effects on tumor growth in AGS (zeige JAG1 Proteine) xenografts. Moreover, ASNS was found to be up-regulated in human gastric cancer tissues compared with matched normal colon tissues.
role of ASNS in melanoma cells A375 and human epidermoid carcinoma cell line A431
Polymorphisms of ASNS are associated with an increased risk of asparaginase-related complications in children with acute lymphoblastic leukemia.
Data shows that high ASNS expression in NK/T cell lymphoma is correlated with worse clinicopathological features.
ASNS deficiency is correlated with poor therapeutic response and worse survivals in patients with rectal cancer receiving neoadjuvant CCRT
cell differentiation was enhanced when asparagine in the culture media was depleted by an addition of L-asparaginase (zeige ASRGL1 Proteine), indicating that downregulation of asparagine synthetase gene expression
The results suggest that NSR1 (zeige SCARF2 Proteine)/MYR2 (zeige MYO1C Proteine) plays a role in Nitrogen (N) reutilization as a negative regulator through controlling ASN1 expression.
ASN1-encoded asparagine synthetase in floral organs contributes to nitrogen filling in Arabidopsis seeds
bZIP11 target processes are identified using transiently increased nuclear bZIP11 levels and genome-wide expression analysis; the effect of bZIP11 on ASN1 and GBF6 are reported.
The protein encoded by this gene is involved in the synthesis of asparagine. This gene complements a mutation in the temperature-sensitive hamster mutant ts11, which blocks progression through the G1 phase of the cell cycle at nonpermissive temperature. Alternatively spliced transcript variants have been described for this gene.
, Asparagine synthetase
, asparagine synthetase [glutamine-hydrolyzing]
, glutamine-dependent asparagine synthetase
, TS11 cell cycle control protein
, Glutamine-dependent asparagine synthetase
, asparagine synthetase 1