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opposing gradients of Wnt5a (zeige WNT5A Proteine) and Wnt5b and of their Sfrp inhibitors, together with intercellular signaling via planar cell polarity proteins, polarize node cells along the anterior-posterior axis for breaking of left-right symmetry.
Wnt5b activated known calcium-dependent signaling pathways and JNK (zeige MAPK8 Proteine), a component of the planar cell polarity pathway.
Secreted Wnt (zeige WNT2 Proteine) glycoproteins, expressed by thymic epithelial cells and thymocytes, regulate epithelial Foxn1 (zeige FOXN2 Proteine) expression in both autocrine and paracrine fashions. Wnt (zeige WNT2 Proteine) molecules therefore provide regulatory signals critical for thymic function.
Data indicate that Wnt5a (zeige WNT5A Proteine) and Wnt5b control the pace of transitions between different chondrocyte zones.
Wnt5b may promote adipogenesis in 3T3-L1 cells, at least in part, by antagonizing the canonical Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) pathway
hCG (zeige CGA Proteine) was found to up-regulate these wnt (zeige WNT2 Proteine) ligands in mouse mammary gland, independent of the changes in ovarian steroidogenesis
this study aimed at defining the expression profile and function of Wnt5a (zeige WNT5A Proteine) and Wnt5b during adipogenesis by determining their effect on aP2 (zeige TFAP2A Proteine) and PPARgamma (zeige PPARG Proteine) expression and assessing the level of beta-catenin (zeige CTNNB1 Proteine) translocation in mouse 3T3-L1 preadipocytes.
Together these findings provide important and novel insights into the role of canonical Wnt (zeige WNT2 Proteine) signals during the patterning of vertebrate ectoderm and indicate that Wnt (zeige WNT2 Proteine) inhibition plays a central role in the process of neural induction.
exaggerated WNT-5B expression upon cigarette smoke exposure in the bronchial epithelium of COPD (zeige ARCN1 Proteine) patients leads to TGF-beta (zeige TGFB1 Proteine)/Smad3 (zeige SMAD3 Proteine)-dependent expression of genes related to airway remodelling
were not able to replicate or further verify the genetic association of polymorphisms in WNT4 (zeige WNT4 Proteine) and WNT5B with bone mineral density
the data suggest that WNT5B induces tube formation by regulating the expression of Snail (zeige SNAI1 Proteine) and Slug proteins through activation of canonical and non-canonical WNT (zeige WNT2 Proteine) signalling pathways.
Noncanonical Wnt (zeige WNT2 Proteine) signaling via Wnt5a (zeige WNT5A Proteine)/5b/11 may have role in the pathogenesis of aortic valve calcification.
WNT-5B induces IL-6 (zeige IL6 Proteine) and CXCL8 (zeige IL8 Proteine) secretion in pulmonary fibroblasts.
overexpression of WNT5B significantly increased cell proliferation, migration and invasion capacities of the COLO 205 cells in vitro. WNT5B may play an important role in the tumorigenesis of colorectal cancer.
results suggest that Wnt5b-associated exosomes promote cancer cell migration and proliferation in a paracrine manner
these results suggest that TGF-beta1 (zeige TGFB1 Proteine) stimulates HSC-4 cell invasion through the Slug/Wnt-5b/MMP-10 (zeige MMP10 Proteine) signalling axis.
This study identified WNT5B and CTNNBL1 for peak bone mineral density and body composition in males from the Han Chinese ethnic group.
The interaction between Wnt (zeige WNT2 Proteine) isoforms and their LRP6 (zeige LRP6 Proteine) cognate receptor depends on the jutting loop present in Wnt3a (zeige WNT3A Proteine) but absent in Wnt5b.
the chaperon Wls (zeige WLS Proteine) and its ligands Wnt9a (zeige WNT9A Proteine) and Wnt5b are expressed in the ectoderm, whereas juxtaposed chondrocytes express Frzb (zeige FRZB Proteine) and Gpc4 (zeige GPC4 Proteine).
disruption of wls (zeige WLS Proteine) resulted in a significant loss of craniofacial bone, whereas lack of gpc4 (zeige GPC4 Proteine), wnt5b and wnt9a (zeige WNT9A Proteine) resulted in severely delayed endochondral ossification.
novel mechanism for Wnt5b and Gpc4 (zeige GPC4 Proteine) regulation of chondrocyte behavior that is independent of the core Wnt (zeige WNT2 Proteine)/PCP (zeige PRCP Proteine) molecules and differs from their collaborative action of controlling cell movements during gastrulation
In embryos overexpressing lbx1b (zeige Lbx1 Proteine), wnt5b, a ligand of the non-canonical Wnt (zeige WNT2 Proteine)/planar cell polarity (PCP (zeige PRCP Proteine)) pathway, was significantly downregulated.
Swap70b and Def6a (zeige DEF6 Proteine) delineate Wnt11 (zeige WNT11 Proteine) and Wnt5b signalling pathways and have roles in convergent and extension cell movement during zebrafish gastrulation
CNBP (zeige CNBP Proteine) up-regulates tbx2b and smarca5 (zeige SMARCA5 Proteine), and down-regulates wnt5b gene expression.
def6 (zeige DEF6 Proteine) morphants phenocopy Wnt5b mutants and ectopic overexpression of def6 (zeige DEF6 Proteine) essentially rescues Wnt5b morphants, indicating a novel role for def6 (zeige DEF6 Proteine) as a central GEF (zeige SLC2A4RG Proteine) downstream of Wnt5b signaling
identify rgs3 (zeige RGS3 Proteine) as having an overlapping expression pattern with wnt5b in zebrafish and reveal that individual knockdown of either rgs3 (zeige RGS3 Proteine) or wnt5b gene function produces similar somite patterning defects.
Data suggest that full-length Ryk (zeige RYK Proteine) conveys Wnt5b signals in a directional manner during gastrulation.
Data suggest that the Wnt-5 loss-of-function defect is consistent with calcium modulation having an antagonistic interaction with Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signaling.
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 94% and 80% amino acid identity to the mouse Wnt5b protein and the human WNT5A protein, respectively. Alternative splicing of this gene generates 2 transcript variants.
wingless-type MMTV integration site family, member 5B
, protein Wnt-5b
, protein Wnt-5c
, wingless-type MMTV integration site family, member 5
, WNT-5B protein
, wingless-related MMTV integration site 5B
, pipe tail