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Induction of cell stress alters the actin cytoskeleton in intestinal epithelial cells via changes in the actin-binding proteins villin-1 and gelsolin (zeige GSN Proteine).
Villin 1 is released in plasma during acute kidney injury and shows potential as an early marker for proximal tubular injury/necrosis.
Villin has a higher positive expression in Primary Pulmonary Enteric Adenocarcinoma cases. Villin proved to be a very sensitive and helpful enteric marker in the differential diagnosis between PEAC and other lung adenocarcinomas.
villin directly interacts with a transcriptional corepressor and ligand of the Slug promoter, ZBRK1.
Data indicate an association between highly fucosylated glycans and caudal type homeobox 1 (CDX1 (zeige CDX1 Proteine)) and/or villin mRNA expression that both correlate with cell differentiation.
study demonstrates that G. duodenalis-mediated disruption of villin is, at least, in part dependent on activation of myosin light chain kinase (zeige MYLK Proteine)
Thus, villin plays an important role in establishing the balance between actin polymerization and actin severing to facilitate the initial steps of Salmonella entry.
Collective expression pattern of tensin/profilin-1 (zeige PFN1 Proteine)/villin-1/talin could be a biomarker to estimate the prognosis of esophageal squamous cell carcinoma patients.
harmonin (zeige USH1C Proteine) and villin autoantibodies are sensitive and specific markers of IPEX (zeige FOXP3 Proteine), differentiate IPEX (zeige FOXP3 Proteine), including atypical cases, from other early childhood disorders associated with enteropathy
villin immunohistochemistry is a reliable and superior adjunct in the diagnosis of microvillus inclusion disease
Competition between tryptophan fluorescence and electron transfer during unfolding of the villin headpiece.
villin severs F-actin to ensure microvillus depolarization and enterocyte remodeling upon intestinal injury
Villin-Cre(+);Klf4 (zeige KLF4 Proteine)(fl/fl (zeige FLT3LG Proteine)) have greater susceptibility to chemical-induced gastric carcinogenesis and increased rates of gastric tumor progression than control mice.
The data establish that meprins interact with and cleave villin and actin, and these cytoskeletal proteins are substrates for meprins.
a lack of villin does not significantly alter basal and secretagogue-stimulated electrolyte movements across the epithelium of the mouse jejunum in vivo
These results indicate that an important patterning event involving villin expression occurs in the gut (zeige GUSB Proteine) epithelium at 16 days, which may define the epithelial boundary between stomach and intestine.
different regulatory sequences of the villin gene regulate expression in the intestinal epithelium
Data show that villin, characteristic markers of brush borders, become abnormally distributed along these atypical basolateral membranes in gal3 (zeige LGALS3 Proteine)(-/-) mice.
Villin is an actin regulatory protein that organizes, integrates and regulates multiple epithelial cell functions.
This gene encodes a member of a family of calcium-regulated actin-binding proteins. This protein represents a dominant part of the brush border cytoskeleton which functions in the capping, severing, and bundling of actin filaments. Two mRNAs of 2.7 kb and 3.5 kb have been observed\; they result from utilization of alternate poly-adenylation signals present in the terminal exon.
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