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Knockdown of Cripto-1 (zeige CFC1 Proteine) inhibits the proliferation, migration, invasion, and angiogenesis in prostate carcinoma cells.
Results identified elevated CR-1 expression in esophageal squamous cell carcinoma (ESCC) specimens which correlated to poor prognosis of the patients. CR-1 high cells isolated from ESCC cells possess cancer stem-like cells (ECSLC) properties.
These results highlight a functional role for CRIPTO and GRP78 (zeige HSPA5 Proteine) in prostate cancer metastasis and suggest that targeting CRIPTO/GRP78 (zeige HSPA5 Proteine) signaling may have significant therapeutic potential.
PGAP6 plays a critical role in Nodal signaling modulation through CRIPTO shedding.
Upregulation of cripto-1 (zeige CFC1 Proteine) is associated with prostate cancer.
the miR (zeige MLXIP Proteine)-15b expression is negatively associated with the cripto-1 (zeige CFC1 Proteine) expression in glioma cells. miR (zeige MLXIP Proteine)-15b may subsequently impair growth and invasion of glioma cells through targeted regulation of cripto-1 (zeige CFC1 Proteine).
These findings suggest that CRIPTO expression may be a useful serological marker for diagnostic and/or prognostic purposes during germ cell cancer management.
serum CR-1 is a useful diagnostic and prognostic marker for nonsmall cell lung cancer patients.
Cripto-1 (zeige CFC1 Proteine) overexpression contributes to aggressiveness and poor prognosis of hepatocellular carcinoma
The main signaling pathways mediating Cripto-1 (zeige CFC1 Proteine) effects include Nodal-dependent (Smad2 (zeige SMAD2 Proteine)/3) and Nodal-independent (Src (zeige SRC Proteine)/p44 (zeige GTF2H2 Proteine)/42/Akt (zeige AKT1 Proteine)) signaling transduction pathways
Cripto controls the metabolic reprogramming in mouse embryonic stem cell to mouse epiblast stem cell transition.
MEF2C (zeige MEF2C Proteine) has a role in regulating outflow tract alignment and transcriptional control of Tdgf1
Dissection of the mechanism by which this occurs indicates that mCripto-1 activates receptor activator NF-kappaB (zeige NFKB1 Proteine)/receptor activator NF-kappaB (zeige NFKB1 Proteine) ligand, and NF-kappaB (zeige NFKB1 Proteine) signaling pathways.
our findings strongly suggest that Cripto-1 (zeige CFC1 Proteine) is a potential driver of mammary tumorigenesis
CR1 protein fragments bind tightly to PfRh4 and also function as soluble inhibitors to block PfRh4 binding to red blood cells and to inhibit the PfRh4-CR1 invasion pathway
Data show that Cripto haploinsufficiency may be associated with increased tumorigenesis, suggesting that the effect of Cripto on tumor development is more complex and may strongly depend on the cellular context.
Cripto is transiently expressed in early differentiating myocardial cells of the left ventricle, right ventricle and outflow tract between late head fold stages and E8.5.
Cripto plays a critical role during mouse gastrulation, especially in mesoderm and endoderm formation
Cripto, a regulator of early embryogenesis, is a novel regulator of muscle regeneration and satellite cell progression toward the myogenic lineage.
Reduced expression of Oep causes the loss of responsiveness to Nodal signals in the prospective ectoderm. Indeed, extending the presence of Oep prolongs the window of competence to respond to Nodal signals.
Late zygotic oep mutants have strongly reduced or absent pitx2 (zeige PITX2 Proteine) expression in the lateral plate mesoderm (LPM), but this expression can be rescued to strong levels by restoring oep in midline structures only.
Nodal-BMP signaling cascade drives left-right heart morphogenesis by regulating the speed and direction of cardiomyocyte movement
Using mutants in the Nodal receptor cofactor one-eyed pinhead (oep) and the T-box transcription factors spadetail (spt (zeige AGXT Proteine)) and no tail (ntl), we were able to define distinctive regulation underlying these sequential phases of PGP midline migration
heterozygote mutations in fgf8 (zeige FGF8 Proteine), shh (zeige SHH Proteine) or oep lead to a reduced number of ascending dopaminergic neurons in zebrafish and may confer increased susceptibility to the Parkinson disease
Vg1 and GDF1 (zeige GDF1 Proteine) signaling require one-eyed pinhead.
Interplay between FGF, one-eyed pinhead (zoep), and T-box transcription factors spt (zeige AGXT Proteine) and ntl during zebrafish posterior
Spatial and temporal regulation of FRL1 protein expression during the gastrula stage are demonstrated.
findings show that vegetal cell-specific translational repression of xCR1 mRNA contributes to the spatially restricted accumulation of the xCR1 protein in Xenopus embryos
This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants.
cripto-1 growth factor
, epidermal growth factor-like cripto protein CR1
, TERATOCARCINOMA-DERIVED GROWTH FACTOR PRECURSOR (EPIDERMAL GROWTH FACTOR-LIKE CRIPTO PROTEIN) (CRIPTO GROWTH FACTOR)
, cripto growth factor
, epidermal growth factor-like Cripto protein
, teratocarcinoma-derived growth factor
, cryptic protein
, one eyed pinhead
, teratocarcinoma-derived growth factor 1
, fibroblast growth factor receptor ligand 1
, teratocarcinoma-derived growth factor 3