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our study found that increased SULF1 expression is significantly predictive of more advanced tumor stage and poorer metastasis-free survival and disease-specific survival in patients with both UTUC and UBUC.
Data show that sulfatase 1 (hSulf-1) overexpression in melanoma cells can inhibit cell proliferation and induce cell cycle arrest and apoptosis by decreasing the protein kinase B (AKT (zeige AKT1 Proteine)) phosphorylation and limiting cyclin dependent kinase 4 (CDK4 (zeige CDK4 Proteine)) nuclear import.
Sulf-1 is responsive to TNF-alpha (zeige TNF Proteine) stimulation and may function as an autocrine regulator of fibroblast expansion in the course of an inflammatory response
The short variants of Sulf1 promoted FGF2 (zeige FGF2 Proteine)-induced MDA-MB231 and MCF7 in vitro growth while full-length Sulf1 inhibited growth supporting in vivo mammary tumour cell signalling patterns of growth.
The SULF1/SULF2 activation thus does not only promote regulated foetal growth and injury-induced liver regeneration but also dysregulated tumour growth.
Results show that SULF1 or SULF2 (zeige SULF2 Proteine) overexpression contributes to colorectal cancer cell proliferation, migration, and invasion.
Data suggest that Sulfatase 1 (hSulf-1) may be a suitable target for cancer therapy.
findings show an upregulation of SULF1 in degenerative discs for the first time, and suggest that there is a link between SULF1 and disc degeneration
rs6990375 polymorphism of SULF1 gene could be one of the factors related to recurrent miscarriage in Iranian women.
Loss of HSulf-1 expression promotes tumorigenicity in ovarian cancer through regulating Bim (zeige BCL2L11 Proteine) expression.
Sulf1 is required for terminating intestinal stem cell division at the end of regeneration.
vertebrate and Drosophila Sulfs have an intrinsically similar activity and the function of Sulfs in the fate of Wnt/Wg ligands is context-dependent
DSulfatase-1 fine-tunes Hedgehog (zeige SHH Proteine) patterning activity through a novel regulatory feedback loop.
The results demonstrate that sulf1 is a novel Wg target gene and by a feedback mechanism, it negatively regulated Wg signaling and distribution in vivo.
Drosophila heparan sulfate 6-O endosulfatase regulates Wingless morphogen (zeige SHH Proteine) gradient formation
Shh (zeige SHH Proteine) signaling requires the coordinated activity of Sulf1 and Sulf2 (zeige SULF2 Proteine) in order to reach that threshold in the mouse ventral spinal cord
our findings show that Sulf-1 is an important tumor suppressor gene in hepatocellular carcinoma (HCC (zeige FAM126A Proteine)), and its over expression downregulates Msln (zeige MSLN Proteine) and results in a decrease in HCC (zeige FAM126A Proteine) cell proliferation, migration, invasion, and lymphatic metastasis.
Sulf1 and Sulf2 (zeige SULF2 Proteine) play indispensable roles to maintain glomerular integrity and protective roles in diabetic nephropathy, probably by growth factor modulation.
Expression of the heparan sulfate 6-O-endosulfatases, Sulf1 and Sulf2 (zeige SULF2 Proteine), in the avian and mammalian inner ear suggests a role for sulfation during inner ear development.
Our study proposes a novel role of SULF1 in hepatocellular carcinoma tumor progression through augmentation of the TGF-beta (zeige TGFB1 Proteine) pathway, thus defining SULF1 as a potential biomarker for tumor progression and a novel target for drug development for HCC (zeige FAM126A Proteine).
It is proposed that Sulf1, Sulf2 (zeige SULF2 Proteine) and ErbB1 (zeige EGFR Proteine) are involved in the inhibition of neurite outgrowth and may regulate structural plasticity and regeneration in the nervous system.
Sulf1/, but not Sulf2 (zeige SULF2 Proteine)/, mice, exhibited a marked delay in healing of corneal epithelial wounds.
Distinct expression patterns of Sulf1 and Hs6st1 (zeige HS6ST1 Proteine) spatially regulate heparan sulfate sulfation during prostate development.
Our study provides additional insights into the temporal control of Olig2 (zeige OLIG2 Proteine) progenitor cell fate change by the identification of Sulf1 as an extracellular timing signal in the ventral spinal cord.
Sulf1 and Sulf2 (zeige SULF2 Proteine) differentially contribute to the generation of organ-specific sulfation patterns of heparan sulfate.
lack of SULF1 expression downregulates VEGFA (zeige VEGFA Proteine)-mediated arterial marker expression, confirming that Sulf1 mediates arterial specification by regulating VegfA165 activity.
Sulf1 triggers Shh (zeige SHH Proteine) signaling activity to establish and, later on, modify the spatial arrangement of gene expression in ventral neural progenitors
Data indicate that sulf1 plays a crucial role in modulating both BMP and FGF signaling.
Zebrafish sulf1 and sulf2a (zeige SULF2 Proteine) are broadly expressed in the central nervous system (CNS) and non-neuronal tissue including heart, somite boundaries, olfactory system, and otic vesicle.
Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF1, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005
extracellular sulfatase Sulf-1
, sulfatase FP
, sulfatase FP1c
, sulfatase 1
, extracellular 6-O-endosulfatase
, extracellular sulfatase Sulf-1-like