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Human RAB7A Protein expressed in HEK-293 Cells - ABIN2730367
Ye, Gao, Tian, Yearsley, Lange, Robertson, Barsky: Early to intermediate steps of tumor embolic formation involve specific proteolytic processing of E-cadherin regulated by Rab7. in Molecular cancer research : MCR 2012
Hepatitis C virus (HCV) modifies cellular trafficking by cleaving Rab interacting lysosomal protein (RILP (zeige RILP Proteine)), which serves to redirect ras-related protein Rab-7 (Rab7 (zeige RAB7B Proteine))-containing vesicles to a kinesin-dependent trafficking mode promoting virion secretion.
Rab7 (zeige RAB7B Proteine) GTPase (zeige RACGAP1 Proteine) plays a key role in regulating MDSCs development, differentiation, trans-endothelial migration, anti-tumor immunity and direct tumor stimulation through physical interaction with the mTOR (zeige FRAP1 Proteine) complexes.
The results were indicative that rabies virus N proficiently colocalized with Rab5 (zeige RAB5A Proteine)/EEA1 (zeige EEA1 Proteine) and Rab7 (zeige RAB7B Proteine)/LAMP1 (zeige LAMP1 Proteine) in both cell lines at 24 and 48 h post-infection, while N titers significantly decreased in early infection of rabies virus.
We provide evidence here that Rab7 (zeige RAB7B Proteine) is a substrate of Src kinase (zeige CSK Proteine), and is tyrosine-phosphorylated by Src (zeige SRC Proteine), withY183 residue of Rab7 (zeige RAB7B Proteine) being the optimal phosphorylation site for Src (zeige SRC Proteine). Further investigations demonstrated that the tyrosine phosphorylation of Rab7 (zeige RAB7B Proteine) depends on the guanine nucleotide binding activity of Rab7 (zeige RAB7B Proteine) and the activity of Src kinase (zeige CSK Proteine).
clear effect of subcutaneous zoledronic acid administration in vivo on the prenylation of Rab1A (zeige RAB1A Proteine), Rab5B (zeige RAB5B Proteine), Rab7A and Rab14 (zeige RAB14 Proteine) in mouse peritoneal macrophages, confirming that systemic treatment with bisphosphonate drug can inhibit prenylation in myeloid cells in vivo outside the skeleton.
increased endolysosomal iron causes cell death associated with increased cytosolic oxidative stress as well as autophagic impairments, and these effects are subject to modulation by endolysosomal ion channel activity in a RAB7A-dependent manner
WDR91 serves as a Rab7 (zeige RAB7B Proteine) effector that is essential for neuronal development by facilitating endosome conversion in the endosome-lysosome pathway.
The Vici syndrome protein EPG5 is a Rab7 (zeige RAB7B Proteine) effector that determines the fusion specificity of autophagosomes with late endosomes/lysosomes.
up-regulation of RAB7A reported in Alzheimer's disease, could contribute to the extracellular accumulation of pathological TAU
Rab7 (zeige RAB7B Proteine) accumulated in GCase (zeige GBA Proteine) deficient cells, supporting the notion that lysosomal recycling is impaired. Since recombinant GCase (zeige GBA Proteine) can reverse ALR (zeige GFER Proteine) impairment, we anticipate that strategies to restore GCase (zeige GBA Proteine) activity in the brains of both sporadic patients with PD and those with GBA1 (zeige GBA Proteine) mutations will improve autophagy lysosomal pathway, preventing the accumulation of a-synuclein and spread of pathology.
MON1/CALCIUM CAFFEINE ZINC SENSITIVITY1 (CCZ1)-mediated Rab7 activation was indispensable for vacuolar trafficking of tapetum degradation-related cysteine proteases.
High Rab7 expression is associated with tumor growth and metastasis.
WDR91 serves as a Rab7 effector that is essential for neuronal development by facilitating endosome conversion in the endosome-lysosome pathway.
Vps34 (zeige PIK3C3 Proteine) has a previously unknown role in regulating Rab7 activity and late endosomal trafficking.
Rab7 accumulated in GCase (zeige GBA Proteine) deficient cells, supporting the notion that lysosomal recycling is impaired. Since recombinant GCase (zeige GBA Proteine) can reverse ALR (zeige GFER Proteine) impairment, we anticipate that strategies to restore GCase (zeige GBA Proteine) activity in the brains of both sporadic patients with PD and those with GBA1 (zeige GBA Proteine) mutations will improve autophagy lysosomal pathway, preventing the accumulation of a-synuclein and spread of pathology.
The up-regulation of Rab11 (zeige RAB11A Proteine), Rab7, or RILP (zeige RILP Proteine), but not its truncated form RILP (zeige RILP Proteine)-C33 (zeige CD82 Proteine), rescued LAMP2A-defective trafficking in cystinosis, whereas dominant-negative Rab11 (zeige RAB11A Proteine) or Rab7 impaired LAMP2A trafficking.
The inhibition of autophagosome-lysosome fusion induced by SapM is dependent on the interaction between SapM and Rab7.
Prion (zeige PRNP Proteine) infection impairs lysosomal degradation capacity by interfering with rab7 membrane attachment in neuronal cells.
photoreceptor outer segments vesicles engulfed through Lyar-dependent pathway were targeted to phagosomes and colocalized with phagosome marker Rab7
B cell Rab7 mediates induction of activation-induced cytidine deaminase (zeige AICDA Proteine) expression and class-switching in T-dependent and T-independent antibody responses.
CREG1 (zeige CREG1 Proteine) deficiency influenced the maturation of lysosomes and reduced the espression of Rab7, which might be involved in CREG1 (zeige CREG1 Proteine)-induced cardiomyocyte autophagy.
Data provide new insight into how disease-associated alterations in Rab7 protein disrupt cellular function in vertebrate sensory neurons. Moreover, findings suggest that defects in axon development may be a previously unrecognized component of Charcot-Marie-Tooth2b disease.
The established transgenic lines ubiquitously express EGFP fusions of Rab5c (zeige Rab5c Proteine) (early endosomes), Rab11a (zeige RAB11A Proteine) (recycling endosomes), and Rab7 (late endosomes) to study localization and dynamics during development.
RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. This gene encodes a RAB family member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This encoded protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly conserved amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2 neuropathies.
RAB7, member RAS oncogene family
, Ras-associated protein RAB7
, ras-related protein Rab-7a
, ras-related protein BRL-RAS
, ras-related protein p23
, GTP-binding protein (rab7)
, ras-related protein Rab-7
, RAB7A, member RAS oncogene family
, rab7A protein
, ras-related protein rab-7a