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findings suggested E. faecalis LTA (zeige LTA Proteine) may increased macrophages autophagy via inhibiting PI3K/Akt (zeige AKT1 Proteine)/mTOR (zeige FRAP1 Proteine) pathway and this process was Beclin1 (zeige BECN1 Proteine) dependent.
LncARSR promotes hepatic lipogenesis via Akt (zeige AKT1 Proteine)/SREBP-1c (zeige SREBF1 Proteine) pathway and contributes to the pathogenesis of nonalcoholic steatohepatitis.
TLR2 confers a pivotal role in allergic airway inflammation via regulating the PI3K/Akt (zeige AKT1 Proteine) signaling pathway-related autophagy in mice.
Finally, EGCG remarkably inhibited compound 48/80-induced phosphorylation of extracellular signal-regulated kinase (ERK (zeige EPHB2 Proteine)) and imiquimod-induced p-AKT (zeige AKT1 Proteine) in the spinal cord of mice, respectively. Collectively, these results indicated EGCG could be a promising strategy for anti-itch therapy.
both AKT phosphorylation and RAC-dependent membrane ruffling were markedly reduced by depletion of either APPL1 or MYO6. These results place MYO6 and its binding partners at a central nexus in cellular signaling linking actin dynamics at the cell surface and endosomal signaling in the cell cortex.
TXNIP (zeige TXNIP Proteine) is a direct substrate of protein kinase B (AKT (zeige AKT1 Proteine)) and is responsible for mediating AKT (zeige AKT1 Proteine)-dependent acute glucose influx after growth factor stimulation.
Influence of 1mM MbetaCD on the fenoterol-driven changes in both contractility and NO level was strongly attenuated by inhibition of Gi-protein (pertussis toxin), Akt (Akt 1 (zeige AKT1 Proteine)/2 kinase inhibitor) or NO-synthase (L-NAME)..Obtained results suggest that slight cholesterol depletion upregulates Gi-protein/Akt (zeige AKT1 Proteine)/NO-synthase signaling that attenuates the positive inotropic response to b2-adrenergic stimulation
Akt1 (zeige AKT1 Proteine) conditions the normal circadian rhythm in the vasculature more so than in other peripheral tissues where other AKT (zeige AKT1 Proteine) isoforms or kinases might be important for daily rhythms.
UVB-irradiated or aged mice skin revealed that mTORC2 (zeige CRTC2 Proteine) activity was significantly upregulated which in turn increased Akt (zeige AKT1 Proteine) activation and Akt (zeige AKT1 Proteine)-dependent IkappaB kinase alpha (zeige CHUK Proteine) (IKKalpha (zeige CHUK Proteine)) phosphorylation, and The increased mTORC2 (zeige CRTC2 Proteine) signaling pathway during skin aging were associated to NF-kappaB (zeige NFKB1 Proteine) activation.
this study reveals the function of IL-15 (zeige IL15 Proteine) in astrocyte survival via Akt (zeige AKT1 Proteine) phosphorylation in response to OGD (zeige FGFR1 Proteine)-induced damage.
Interestingly, rs2279590 locus has a widespread enhancer effect on two nearby genes, protein tyrosine kinase 2 beta (PTK2B) and epoxide hydrolase-2 (EPHX2 (zeige EPHX2 Proteine)); both of which have been previously associated with AD as risk factors.
thrombin (zeige F2 Proteine) binding to PAR-1 (zeige MARK2 Proteine) receptor activated Gi-protein/c (zeige PROC Proteine)-Src (zeige SRC Proteine)/Pyk2/EGFR (zeige EGFR Proteine)/PI3K (zeige PIK3CA Proteine)/Akt (zeige AKT1 Proteine)/p42/p44 (zeige PSMC6 Proteine) MAPK (zeige MAPK3 Proteine) cascade, which in turn elicited AP-1 (zeige FOSB Proteine) activation and ultimately evoked MMP-9 (zeige MMP9 Proteine) expression and cell migration in SK-N-SH cells.
Multiple myeloma that is driven by deregulated iron homeostasis and/or Pyk2/beta-cateninn signaling is susceptible to deferasirox-induced apoptosis.
In summary, our data suggested that PYK2 via S6K1 (zeige RPS6KB1 Proteine) activation modulated AR function and growth properties in prostate cancer cells. Thus, PYK2 and S6K1 (zeige RPS6KB1 Proteine) may potentially serve as therapeutic targets for PCa (zeige FLVCR1 Proteine) treatment.
Our findings suggest that Pyk2 plays an important role in the coordination of stabilization of beta-catenin (zeige CTNNB1 Proteine) in the crosstalk between Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) and Wnt (zeige WNT2 Proteine)/Ca(2 (zeige CA2 Proteine)+) signaling pathways upon Wnt3a (zeige WNT3A Proteine) stimulation in differentiating hNPCs.
STIM1 (zeige STIM1 Proteine)-induced Ca(2 (zeige CA2 Proteine)+) signaling activates Pyk2 to inhibit the interaction of VE-PTP (zeige PTPRB Proteine) and VE-cadherin (zeige CDH5 Proteine) and hence increase endothelial permeability.
Ascites and CCL18 (zeige CCL18 Proteine) stimulate the phosphorylation and expression of Pyk2, which positively regulates ascites-induced ovarian cancer cell migration.
We demonstrated trophoblast cytoprotection by intervention with supraphysiological concentrations of relaxin, a process in part mediated through the PI3-kinase (zeige PIK3CA Proteine)-Akt/PKB (zeige AKT1 Proteine) cell survival pathway. These results provide further rationale for clinical investigation of relaxin as a potential therapeutic in preeclampsia.
PTK2B polymorphism (rs28834970) could modify the risk of late-onset Alzheimer's disease (LOAD), and PTK2B polymorphism (rs28834970) and APOE may interact to increase LOAD risk in a Han Chinese population.
Studies suggest that PYK2 is a common downstream effector of ErbB (zeige EGFR Proteine) and IL8 (zeige IL8 Proteine) receptors, and that PYK2 integrates their signaling pathways through a positive feedback loop to potentiate breast cancer invasion.
Ptk2b activation may play a key role in the signaling responses in ECs under hemodynamic influence [proline-rich tyrosine kinase 2]
This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene.
, PKB alpha
, RAC-alpha serine/threonine-protein kinase
, protein kinase B alpha
, protein kinase B-alpha
, proto-oncogene c-AKT
, related to A and C kinases
, FADK 2
, PTK2B protein tyrosine kinase 2 beta
, calcium-dependent tyrosine kinase
, calcium-regulated non-receptor proline-rich tyrosine kinase
, cell adhesion kinase beta
, focal adhesion kinase 2
, proline-rich tyrosine kinase 2
, protein kinase B
, protein-tyrosine kinase 2-beta
, related adhesion focal tyrosine kinase
, cellular adhesion kinase beta
, protein tyrosine kinase 2 beta
, CAK beta
, PTK2 protein tyrosine kinase 2 beta
, protein tyrosine kinase 2.2
, protein tyrosine kinase 2aa
, protein tyrosine kinase 2b