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these data indicated under cigarette smoke condensate treatment; losing of membrane p120ctn could upregulate surface NEP (zeige MME Proteine) protein level and thus facilitate BEAS-2B cell migration.
Data show that p120-catenin interacts with kinesin family member 23 (MKLP1) to regulate focused rhoA GTP-binding protein (RhoA) activity during cytokinesis.
Results provide evidence that 90K interacts with the E-cadherin (zeige CDH1 Proteine)-p120-catenin complex and induced its dissociation, altering the phosphorylation status of p120-catenin.
Results show that head and neck squamous cell carcinoma tumors with low P120CTN and PI3K (zeige PIK3CA Proteine) pathway mutations have higher levels of MMP1 (zeige MMP1 Proteine) compared to tumors with high P120CTN and no PI3K (zeige PIK3CA Proteine) pathway mutations demonstrating that P120CTN downregulation and PIK3CA (zeige PIK3CA Proteine) mutations promote MMP1 (zeige MMP1 Proteine)-driven invasion.
In 11 BCD (zeige CYP4V2 Proteine) patients from eight families, we identified five CDH1 (zeige CDH1 Proteine) deleterious missense mutations and three CTNND1 truncating mutations.
Our combined data indicate that as HPMECs achieve confluence and CD31 (zeige HBA1 Proteine) ectodomains become homophilically engaged, multiple SFKs are activated to increase tyrosine phosphorylation of p120ctn, which in turn, functions as a cross-bridging adaptor molecule that physically couples NEU1 (zeige NEU1 Proteine) to CD31 (zeige HBA1 Proteine), permitting NEU1 (zeige NEU1 Proteine)-mediated desialylation of CD31 (zeige HBA1 Proteine).
Studied interactions between protein kinase C alpha (PKCalpha (zeige PKCa Proteine)), FOXC2 (zeige FOXC2 Proteine), and p120-catenin (CTNND1) in breast cancer, cell migration/ invasion; found PKCalpha (zeige PKCa Proteine) acts as an upstream regulator of FOXC2 (zeige FOXC2 Proteine), which in turn represses the expression of p120-catenin, in both in endocrine resistant ER+breast cancer and basal A triple negative breast cancer
Studied the association between genetic polymorphisms in the CTNND1 gene and risk of pancreatic carcinoma in Chinese population.
Results found that CTNND1 expression was significantly up-regulated in hepatocellular carcinoma (HCC (zeige FAM126A Proteine)) cancer lesions compared with paired normal liver tissues and, could promote cell proliferation, migration, and invasion in vitro and in vivo. The study provides evidence that CTNND1 functions as a novel tumor oncogene (zeige RAB1A Proteine) in HCC (zeige FAM126A Proteine).
These results suggest that stabilization of delta-catenin (zeige CTNND2 Proteine) by Hakai (zeige CBLL1 Proteine) is dependent on Src (zeige SRC Proteine).
over-expression of P120-catenin suppressed NF-kappaB (zeige NFKB1 Proteine) signaling and reversed the inflammatory effects. P120-catenin prevents endplate chondrocytes from undergoing ICMT (zeige ICMT Proteine)-mediated inflammation by suppressing the expression of NF-kappaB (zeige NFKB1 Proteine).
Stretch induced p120 degradation and the endocytosis of E-cadherin (zeige CDH1 Proteine), which induced beta-catenin (zeige CTNNB1 Proteine) translocation into the nucleus, a key event in lung injury progress and repair.
p120 Catenin underexpression is associated with Invasive Pancreatic Neoplasia.
We conclude that p120ctn is not only an adaptor and regulator of E-cadherin (zeige CDH1 Proteine), but is also indispensable for proper lineage commitment
p120 is required for dietary calcium suppression of oral carcinogenesis.
p120ctn has a critical role in biliary differentiation and is a potent suppressor of liver tumor growth.
a mechanistic link between E-cadherin (zeige CDH1 Proteine) loss and subsequent control of Rho-driven anoikis resistance through p120- and Kaiso (zeige ZBTB33 Proteine)-dependent expression of Wnt11 (zeige WNT11 Proteine), is reported.
Delta-catenin (zeige CTNND2 Proteine) activates Rac1 and Cdc42 (zeige CDC42 Proteine) but inhibits RhoA (zeige RHOA Proteine) in lymphatic endothelial cells.
p120-catenin regulates REST and CoREST (zeige Rcor2 Proteine) and modulates mouse embryonic stem cell differentiation.
Data indicate that p120 catenin is required for proper pancreatic tubulogenesis and branching morphogenesis.
Upregulation of Rac1 activity by Wnt3a temporally correlated with enhanced p120-catenin binding to Rac1 and Vav2.
p120ctn signaling in motor neurons promotes nerve-muscle interaction and neuromuscular junction assembly
Dyrk1A (zeige DYRK1A Proteine) positively and selectively modulates p120-catenin protein levels, thus having an impact on p120-catenin and Kaiso (zeige ZBTB33 Proteine) (and canonical Wnt (zeige WNT2 Proteine)) gene targets such as siamois and wnt11.
The degradation machinery of the canonical Wnt (zeige WNT2 Proteine) pathway modulates p120-catenin protein stability through mechanisms shared with those regulating beta-catenin (zeige CTNNB1 Proteine).
delta-catenin (zeige CTNND2 Proteine) has an essential role in amphibian development, and has functional links to cadherins and Rho-family GTPases
This gene encodes a member of the Armadillo protein family, which function in adhesion between cells and signal transduction. Multiple translation initiation codons and alternative splicing result in many different isoforms being translated. Not all of the full-length natures of the described transcript variants have been determined. Read-through transcription also exists between this gene and the neighboring upstream thioredoxin-related transmembrane protein 2 (TMX2) gene.
cadherin-associated Src substrate
, catenin delta-1
, p120 catenin
, catenin src
, catenin (cadherin-associated protein), delta 1
, catenin delta-1 isoform 1AC
, catenin, delta 1
, catenin delta-1-like