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Human Polyclonal BCAR1 Primary Antibody für - ABIN965642
Brinkman, van der Flier, Kok, Dorssers: BCAR1, a human homologue of the adapter protein p130Cas, and antiestrogen resistance in breast cancer cells. in Journal of the National Cancer Institute 2000
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Human Polyclonal BCAR1 Primary Antibody für IHC - ABIN965641
Eisenmann, McCarthy, Simpson, Keely, Guan, Tachibana, Lim, Manser, Furcht, Iida: Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas. in Nature cell biology 2000
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Mouse (Murine) Polyclonal BCAR1 Primary Antibody für - ABIN965643
Prasad, Topping, Decker: SH2-containing inositol 5'-phosphatase SHIP2 associates with the p130(Cas) adapter protein and regulates cellular adhesion and spreading. in Molecular and cellular biology 2001
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Human Monoclonal BCAR1 Primary Antibody für ICS - ABIN1177115
Goldberg, Alexander, Pellicena, Zhang, Tsuda, Miller: Src phosphorylates Cas on tyrosine 253 to promote migration of transformed cells. in The Journal of biological chemistry 2003
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Human Monoclonal BCAR1 Primary Antibody für ICS - ABIN1177114
Hinsby, Olsen, Bennett, Mann: Signaling initiated by overexpression of the fibroblast growth factor receptor-1 investigated by mass spectrometry. in Molecular & cellular proteomics : MCP 2003
Silencing of p130Cas and inhibition of FAK (zeige PTK2 Antikörper) activity both strongly reduced imatinib and nilotinib stimulated invasion.
the p130Cas FAT domain uniquely confers a mechanosensing function.
Tyrosine phosphorylation of focal adhesion kinase (FAK) and p130 (zeige RBL2 Antikörper) Crk-associated substrate (CAS) was found to be correlated with pancreatic cancer cell invasiveness.
Full-length and truncated p130Cas phosphorylated substrate domain molecules were expressed in breast cancer cells. Breast cancer cells expressing the full-length SD and the functional smaller SD fragment (spanning SD motifs 6-10) were injected into the mammary fat pads of mice. Both the complete and truncated SD significantly increased the occurrence of metastases to multiple organs.
Elevated levels of p130Cas is associated with trastuzumab resistance in breast cancer.
blockade of GD3-mediated growth signaling pathways by siRNAs might be a novel and promising therapeutic strategy against malignant melanomas, provided signaling molecules such as p130Cas and paxillin (zeige PXN Antikörper) are significantly expressed in individual cases.
expression quantitative trait loci studies implicate BCAR1 as the causal gene of coronary artery disease Carotid intima-media thickness
p130(Cas) exon 1 variants display altered functional properties; shorter 1B isoform exhibited diminished FAK (zeige PTK2 Antikörper) binding activity + reduced cell migration + invasion; longest variant 1B1 exhibited the most efficient FAK (zeige PTK2 Antikörper) binding + greatly enhanced migration
these data identify a new p130Cas/Cyclooxygenase-2 (zeige PTGS2 Antikörper) axis as a crucial element in the control of breast tumor plasticity.
Data introduce hitherto unappreciated paradigms whereby reactive oxygen species can reciprocally regulate the cellular localization of pro- and anti-migratory signaling molecules, p130cas and PTEN, respectively.
Data suggest that the first LD motif (LD1; leucine-rich motif) of paxillin (zeige PXN Antikörper) binds to the CCHD (C-terminal region of Cas (zeige CTNND1 Antikörper) family homology domain) of p130Cas/Bcar1 (in a 1:1 stoichiometry with Kd approximately 4.2 uM); p130Cas/Bcar1 CCHD is stabilized by forming complex with paxillin (zeige PXN Antikörper) LD1; these studies utilized chicken paxillin (zeige PXN Antikörper) and mouse p130Cas/Bcar1. (p130Cas/Bcar1 = breast cancer anti-estrogen resistance protein 1)
reduction of p130Cas levels by siRNA affects process outgrowth, the thickness of cellular processes and migration behavior of Oli (zeige TOMM22 Antikörper)-neu cells. long term p130Cas reduction results in increased apoptosis in cultured primary oligodendrocytes.
CRP2 (zeige CEBPB Antikörper) sequesters p130Cas at focal adhesions, thereby reducing lamellipodia formation and blunting vascular smooth muscle cell migration.
p130Cas plays pivotal roles in osteoclastic bone resorption.
31-kDa caspase (zeige CASP3 Antikörper)-generated cleavage product of p130Cas inhibited MyoD (zeige MYOD1 Antikörper)-induced transcriptional activation of muscle-specific (zeige EIF3K Antikörper) genes.
beta1-Integrin signaling within migrating ganglion cell layer cells requires Cas (zeige CTNND1 Antikörper) signaling-adaptor proteins
Crk-associated substrate -vinculin (zeige VCL Antikörper) binding significantly affects the dynamics of Crk-associated substrate and vinculin (zeige VCL Antikörper) within focal adhesions as well as the size of focal adhesions.
we provide evidence that exercise-induced p38 MAPK (zeige MAPK14 Antikörper) signaling is not impaired by the muscle-specific (zeige EIF3K Antikörper) deletion of p130Cas. We conclude that p130Cas plays a limited role in mechanical-stress-induced skeletal muscle adaptation.
study described a molecular complex of PTPalpha (zeige PTPRA Antikörper)-BCAR3 (zeige BCAR3 Antikörper)-Cas (zeige CTNND1 Antikörper)-Src (zeige SRC Antikörper); this complex forms in response to PTPalpha (zeige PTPRA Antikörper) Tyr789 phosphorylation and mediates Cas (zeige CTNND1 Antikörper) localization to focal adhesions and Cas (zeige CTNND1 Antikörper) downstream signaling to promote cell migration
p130Cas phosphorylation, mediated by integrin beta3, facilitates cofilin inactivation and promotes myogenic differentiation through modulating actin cytoskeleton remodelling
bcar3 gene is expressed downstream of Gata2 (zeige GATA2 Antikörper) during gastrulation, and is co-expressed with gata2 (zeige GATA2 Antikörper) but is more broadly expressed during later development; its binding partner, bcar1 shows overlapping expression patterns
BCAR1, or CAS, is an Src (MIM 190090) family kinase substrate involved in various cellular events, including migration, survival, transformation, and invasion (Sawada et al., 2006
Cas scaffolding protein family member 1
, Crk-associated substrate p130Cas
, breast cancer anti-estrogen resistance protein 1
, CRK-associated substrate
, p130 Cas
, v-crk-associated tyrosine kinase substrate
, breast cancer anti-estrogen resistance 1
, breast cancer anti-estrogen resistance protein 1-like