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Human Polyclonal BCAR1 Primary Antibody für IHC - ABIN965641
Brinkman, van der Flier, Kok, Dorssers: BCAR1, a human homologue of the adapter protein p130Cas, and antiestrogen resistance in breast cancer cells. in Journal of the National Cancer Institute 2000
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Human Polyclonal BCAR1 Primary Antibody für - ABIN965642
Eisenmann, McCarthy, Simpson, Keely, Guan, Tachibana, Lim, Manser, Furcht, Iida: Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas. in Nature cell biology 2000
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Human Polyclonal BCAR1 Primary Antibody für IP, ELISA - ABIN548481
Pellicena, Miller: Processive phosphorylation of p130Cas by Src depends on SH3-polyproline interactions. in The Journal of biological chemistry 2001
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Human Polyclonal BCAR1 Primary Antibody für ELISA, WB - ABIN548480
Hoon Kim, Jeon Choi, Kook, Kim, Keun Song: Phosphorylation-dependent cleavage of p130cas in apoptotic rat-1 cells. in Biochemical and biophysical research communications 2002
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Chicken Monoclonal BCAR1 Primary Antibody für IF, IP - ABIN533161
Shin, Dise, Schneider-Mergener, Ritchie, Kilkenny, Hanks: Subsets of the major tyrosine phosphorylation sites in Crk-associated substrate (CAS) are sufficient to promote cell migration. in The Journal of biological chemistry 2004
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Human Monoclonal BCAR1 Primary Antibody für ICS - ABIN1177115
Goldberg, Alexander, Pellicena, Zhang, Tsuda, Miller: Src phosphorylates Cas on tyrosine 253 to promote migration of transformed cells. in The Journal of biological chemistry 2003
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Mouse (Murine) Polyclonal BCAR1 Primary Antibody für - ABIN965643
Prasad, Topping, Decker: SH2-containing inositol 5'-phosphatase SHIP2 associates with the p130(Cas) adapter protein and regulates cellular adhesion and spreading. in Molecular and cellular biology 2001
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Human Monoclonal BCAR1 Primary Antibody für ICS - ABIN1177114
Hinsby, Olsen, Bennett, Mann: Signaling initiated by overexpression of the fibroblast growth factor receptor-1 investigated by mass spectrometry. in Molecular & cellular proteomics : MCP 2003
study showed that RBMS1 gene rs7593730 and BCAR1 gene rs7202877 were significantly associated with type 2 diabetes in the Chinese population
These results suggest that miR-24-3p functions as a tumor suppressor and the miR-24-3p/p130Cas axis is a novel factor of cancer progression by regulating cell migration and invasion.
The authors herein prove, for the first time, that the transcriptional repressor Blimp1 is a novel mediator of p130Cas/ErbB2-mediated invasiveness. Indeed, high Blimp1 expression levels are detected in invasive p130Cas/ErbB2 cells and correlate with metastatic status in human breast cancer patients.
the results of our study identify BCAR1 as a prognostic biomarker with potential clinical value for risk stratification of ERG-negative prostate cancer.
Silencing of p130Cas and inhibition of FAK activity both strongly reduced imatinib and nilotinib stimulated invasion.
the p130Cas FAT domain uniquely confers a mechanosensing function.
Tyrosine phosphorylation of focal adhesion kinase (FAK) and p130 Crk-associated substrate (CAS) was found to be correlated with pancreatic cancer cell invasiveness.
Full-length and truncated p130Cas phosphorylated substrate domain molecules were expressed in breast cancer cells. Breast cancer cells expressing the full-length SD and the functional smaller SD fragment (spanning SD motifs 6-10) were injected into the mammary fat pads of mice. Both the complete and truncated SD significantly increased the occurrence of metastases to multiple organs.
Elevated levels of p130Cas is associated with trastuzumab resistance in breast cancer.
blockade of GD3-mediated growth signaling pathways by siRNAs might be a novel and promising therapeutic strategy against malignant melanomas, provided signaling molecules such as p130Cas and paxillin are significantly expressed in individual cases.
expression quantitative trait loci studies implicate BCAR1 as the causal gene of coronary artery disease Carotid intima-media thickness
p130(Cas) exon 1 variants display altered functional properties; shorter 1B isoform exhibited diminished FAK binding activity + reduced cell migration + invasion; longest variant 1B1 exhibited the most efficient FAK binding + greatly enhanced migration
these data identify a new p130Cas/Cyclooxygenase-2 axis as a crucial element in the control of breast tumor plasticity.
Data introduce hitherto unappreciated paradigms whereby reactive oxygen species can reciprocally regulate the cellular localization of pro- and anti-migratory signaling molecules, p130cas and PTEN, respectively.
BCAR1 has a pivotal role in the regulation of tissue homeostasis in pathological conditions such as cancer. (Review)
Cas promotes cell migration by linking actomyosin contractions to the adhesion complexes through interaction with Src and the actin cytoskeleton.
Collectively, these studies demonstrate that p130Cas acts as a bridging molecule between the Kaposi's sarcoma-associated herpesvirus-induced entry signal complex and the downstream trafficking signalosome in endothelial cells.
Our results show that endogenous Cul5 suppresses epithelial cell transformation by several pathways, including inhibition of Src-Cas-induced ruffling through SOCS6
Increased BCAR1 expression is associated with non-small cell lung cancer.
BCAR1 and BCAR3 scaffolding proteins have roles in cell signaling and antiestrogen resistance
CAS localizes to the force transduction layer of focal adhesions and mechanical stress stabilizes CAS in focal adhesions.
Data suggest that the first LD motif (LD1; leucine-rich motif) of paxillin binds to the CCHD (C-terminal region of Cas family homology domain) of p130Cas/Bcar1 (in a 1:1 stoichiometry with Kd approximately 4.2 uM); p130Cas/Bcar1 CCHD is stabilized by forming complex with paxillin LD1; these studies utilized chicken paxillin and mouse p130Cas/Bcar1. (p130Cas/Bcar1 = breast cancer anti-estrogen resistance protein 1)
reduction of p130Cas levels by siRNA affects process outgrowth, the thickness of cellular processes and migration behavior of Oli-neu cells. long term p130Cas reduction results in increased apoptosis in cultured primary oligodendrocytes.
CRP2 sequesters p130Cas at focal adhesions, thereby reducing lamellipodia formation and blunting vascular smooth muscle cell migration.
p130Cas plays pivotal roles in osteoclastic bone resorption.
31-kDa caspase-generated cleavage product of p130Cas inhibited MyoD-induced transcriptional activation of muscle-specific genes.
beta1-Integrin signaling within migrating ganglion cell layer cells requires Cas signaling-adaptor proteins
Crk-associated substrate -vinculin binding significantly affects the dynamics of Crk-associated substrate and vinculin within focal adhesions as well as the size of focal adhesions.
we provide evidence that exercise-induced p38 MAPK signaling is not impaired by the muscle-specific deletion of p130Cas. We conclude that p130Cas plays a limited role in mechanical-stress-induced skeletal muscle adaptation.
study described a molecular complex of PTPalpha-BCAR3-Cas-Src; this complex forms in response to PTPalpha Tyr789 phosphorylation and mediates Cas localization to focal adhesions and Cas downstream signaling to promote cell migration
p130Cas phosphorylation, mediated by integrin beta3, facilitates cofilin inactivation and promotes myogenic differentiation through modulating actin cytoskeleton remodelling
Cas is required for apoptosis that is induced by proteasome inhibition, and potentially by other death stimuli.
results demonstrate that p130Cas is an essential transducer in ErbB2 transformation and highlight its potential use as a novel therapeutic target in ErbB2 positive human breast cancers
Cas plays pivotal roles in liver development through the reorganization of the actin cytoskeleton and formation of fenestrae in sinusoidal endothelial cells.
The Cas utilizes Nck2 to activate Cdc42 and induce cell polarization in response to wounding.
Results describe the role of nitric oxide in regulating the focal adhesion proteins, Src, FAK, p130 Cas, and PTP-alpha.
regulation of tyrosine phosphorylation by focal adhesion kinase
Fluoroaluminate stimulates phosphorylation of p130 Cas and Fak and increases attachment and spreading of preosteoblastic MC3T3-E1 cells.
hyperphosphorylation in STAT3 deficiency in keratinocytes leads to compromised cell migration
Mouse embryonic fibroblasts (MEFs) derived from FAK(-/-) and p130(cas-/-) mice had severe defects in ephrinA1-induced cell spreading.
bcar3 gene is expressed downstream of Gata2 during gastrulation, and is co-expressed with gata2 but is more broadly expressed during later development; its binding partner, bcar1 shows overlapping expression patterns
BCAR1, or CAS, is an Src (MIM 190090) family kinase substrate involved in various cellular events, including migration, survival, transformation, and invasion (Sawada et al., 2006
Cas scaffolding protein family member 1
, Crk-associated substrate p130Cas
, breast cancer anti-estrogen resistance protein 1
, CRK-associated substrate
, p130 Cas
, v-crk-associated tyrosine kinase substrate
, breast cancer anti-estrogen resistance 1
, breast cancer anti-estrogen resistance protein 1-like