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anti-Human ARHGEF7 Antikörper:
anti-Rat (Rattus) ARHGEF7 Antikörper:
anti-Mouse (Murine) ARHGEF7 Antikörper:
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Chicken Monoclonal ARHGEF7 Primary Antibody für IF, WB - ABIN968623
Bagrodia, Taylor, Jordon, Van Aelst, Cerione: A novel regulator of p21-activated kinases. in The Journal of biological chemistry 1998
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Rat (Rattus) Monoclonal ARHGEF7 Primary Antibody für IF, WB - ABIN968624
Manser, Loo, Koh, Zhao, Chen, Tan, Tan, Leung, Lim: PAK kinases are directly coupled to the PIX family of nucleotide exchange factors. in Molecular cell 1998
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Human Polyclonal ARHGEF7 Primary Antibody für ICC, ELISA - ABIN1169227
Oh, Yoo, Jo, Song, Kim, Park: Cloning of a SH3 domain-containing proline-rich protein, p85SPR, and its localization in focal adhesion. in Biochemical and biophysical research communications 1997
S340E mutation enhances Nox1 (zeige NOX1 Antikörper) activation (Kaito et al., 2014), the present study suggests that betaPix can also play an inhibitory role in O2(-) production, depending on the sites of phosphorylation.
Data suggest that Scribble (zeige SCRIB Antikörper) PDZ-domain (zeige INADL Antikörper)-1 and PDZ-domain (zeige INADL Antikörper)-3 are major domains that interact with beta-PIX and exhibit distinct binding hierarchy in interactions between individual Scribble (zeige SCRIB Antikörper) PDZ (zeige INADL Antikörper) domains and beta-PIX. (Scribble (zeige SCRIB Antikörper) = scribbled (zeige SCRIB Antikörper) planar cell polarity protein; beta-PIX = Rho guanine nucleotide exchange factor 7)
each mutation in LRRK2 (zeige LRRK2 Antikörper) and ARHGEF7 demonstrated its unique functional property, which may contribute to the pathogenesis of Parkinson disease
we discuss recent findings in key physiological systems that exemplify current understanding of the function of this important regulatory complex. Further, we draw attention to gaps in crucial information that remain to be filled to allow a better understanding of the many roles of the GIT-PIX complex in health and disease
Data show association of G protein-coupled receptor (zeige ADRA1A Antikörper) kinase-interacting protein (zeige CIB1 Antikörper) 1 (GIT1), p21 (zeige CDKN1A Antikörper)-activated kinase interacting exchange factor (betaPIX), and p21 protein (Cdc42/Rac)-activated kinase 1 (PAK1 (zeige PAK1 Antikörper)) with centrosomes.
Data show the role of Rho guanine nucleotide exchange factor 7 (beta-PIX) to the regulation of high mobility of lung adenocarcinoma cell line H1299 via regulation of focal adhesions dynamics, changes in actin cytoskeleton organization and cell polarity.
Phosphorylation of LRRK2 (zeige LRRK2 Antikörper) by casein kinase 1alpha regulates trans-Golgi clustering via differential interaction with ARHGEF7.
GIT1/betaPIX/Rac1/PAK pathway plays a crucial role in regulating GABA(A)R synaptic stability and hence inhibitory synaptic transmission with important implications for inhibitory plasticity and information processing in the brain.
Conversely, increased expression of betaPIX in breast cancer cell lines re-couples the Hippo kinase cassette to Yap (zeige YAP1 Antikörper)/Taz (zeige TAZ Antikörper), promoting localization of Yap (zeige YAP1 Antikörper)/Taz (zeige TAZ Antikörper) to the cytoplasm and inhibiting cell migration and proliferation.
Data indicate that suppression of c-Cbl (zeige CBL Antikörper) protein by rho guanine nucleotide exchange factor 7 (Cool-1) may be critical for generation of at least a subset of glioblastoma (GBM).
It provides for the first time, to our knowledge, a possible mechanism for the concerted action of tyrosine kinases, GIT1/betaPIX proteins, and Ca(2 (zeige CA2 Antikörper)+) in the propagation of signals leading to the regulation of microtubule nucleation in activated mast cells.
beta-Pix controls the spatial localization of Rac1 activity to drive collective AVE migration at a critical stage in mouse development.
Therefore, we propose that PKCgamma (zeige PRKCG Antikörper) positively modulates dopamine release through beta2PIX phosphorylation.
Glucose stimulates Cav-1 (zeige CAV1 Antikörper) and induces its dissociation from Cdc42 (zeige CDC42 Antikörper), to promote Cdc42 (zeige CDC42 Antikörper)-betaPix binding and Cdc42 (zeige CDC42 Antikörper) activation, and to trigger downstream signaling and ultimately sustain insulin (zeige INS Antikörper) release.
a model by which SNX27 (zeige SNX27 Antikörper) regulates trafficking of beta-Pix to focal adhesions and thereby influences cell motility.
betaPix-b(L) induced pinocytosis through cooperative action of the CH and Dbl (zeige MCF2 Antikörper) homology (DH) domains, demonstrating the role of betaPix-b(L) in the regulation of membrane dynamics
Stat3 binds to betaPIX, a Rac1 activator,and regulates Rac1 activity to modulate the organization of actin cytoskeleton and directional migration
phosphorylation-dephosphorylation cycle of Cool-1 at Tyr (zeige TYR Antikörper)-442 can serve as a key regulatory signal for focal complex assembly-disassembly, and consequently, for the migration and invasive activity of Src (zeige SRC Antikörper)-transformed
P85 beta-PIX, located downstream of Rac1, is a key regulator for the activations of FAK (zeige PTK2 Antikörper) or p38 MAP kinase (zeige MAPK14 Antikörper) and plays a pivotal role in focal complex formation and cell motility.
Rho GTPases play a fundamental role in numerous cellular processes triggered by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It forms a complex with the small GTP binding protein Rac1 and recruits Rac1 to membrane ruffles and to focal adhesions. This protein can induce membrane ruffling. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Rho guanine nucleotide exchange factor (GEF) 7
, Rho guanine nucleotide exchange factor 7
, rho guanine nucleotide exchange factor 7-like
, PAK-interacting exchange factor beta
, SH3 domain-containing proline-rich protein
, guanine nucleotide exchange factor 7
, rho guanine nucleotide exchange factor 7
, Pak interacting exchange factor
, Pak3 binding protein