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anti-Human Adenosine a1 Receptor Antikörper:
anti-Mouse (Murine) Adenosine a1 Receptor Antikörper:
anti-Rat (Rattus) Adenosine a1 Receptor Antikörper:
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Human Polyclonal Adenosine a1 Receptor Primary Antibody für WB - ABIN611319
Bowery, Brown: The cloning of GABA(B) receptors. in Nature 1997
Show all 3 Pubmed References
Human Polyclonal Adenosine a1 Receptor Primary Antibody für IF (p), IHC (p) - ABIN719396
Cao, Dai, Wei, Han, Guan, Li, Liu, Xiao, Li: Effects of cordycepin on spontaneous alternation behavior and adenosine receptors expression in hippocampus. in Physiology & behavior 2017
Cow (Bovine) Polyclonal Adenosine a1 Receptor Primary Antibody für ELISA - ABIN314251
Funakoshi, Chan, Good, Libonati, Piuhola, Chen, MacDonnell, Lee, Herrmann, Zhang, Martini, Palmer, Sanbe, Robbins, Houser, Koch, Feldman: Regulated overexpression of the A1-adenosine receptor in mice results in adverse but reversible changes in cardiac morphology and function. in Circulation 2006
Data suggest that activation of adenosine A1 receptors elicit receptor-operated Ca(2+) entry in porcine afferent arterioles, the level of which is dependent on postnatal maturation of TRPC3 channels.
mRNA for adenosine A(1), A(2A), A(2B (zeige ADRA2B Antikörper)), and A(3) receptors was expressed in arterioles and venules. Protein for A(1), A(2A), and A(2B (zeige ADRA2B Antikörper)), but not A(3), was detected in both microvessel types and was further demonstrated on vascular endothelial cells
studies revealed individual trait characteristics for being either vulnerable or resilient to both alcohol and to sleep deprivation. Both interventions induce gradual increases in cerebral A1AR availability, pointing to a potential common molecular response mechanism.
Data suggested that adenosine A1 receptor might potentiate glycinergic transmission through Galphai/PKA/alpha3 and Gbetagamma/alpha1ins pathways in inflamed rat.
Elevated A1 adenosine receptor is associated with sleep deprivation.
Mutation in ADORA1 may be associated with early-onset parkinsonism and cognitive dysfunction.
This study showed that increased neuronal A1R expression in Rasmussen Encephalitis may be involved in prevention of seizures spread and seizures-induced damage, limitation of both seizures and inflammation atrophy in 1 cerebral hemisphere.
A1R signaling enhances A2AR (zeige ADORA2A Antikörper)-mediated neurodegeneration [review]
Mutational and computational analysis of A1-AR revealed a distinct conformation of the second extracellular loop and a wider extracellular cavity with a secondary binding pocket that can accommodate orthosteric and allosteric ligands.
this study highlights a key role for extracellular loop 2 in A1AR orthosteric ligand binding and receptor activation.
Dysregulation in ADORA1/ADORA2A (zeige ADORA2A Antikörper) expression was associated with glioma development.
A1R mRNA levels and A1R density in PBMCs from idiopathic normal-pressure hydrocephalus patients were significantly lower than control subjects
Loss of A1AR expression results in an increased susceptibility to noise-induced cochlear neural injury and hearing loss.
Expression of the SENP2 (zeige SENP2 Antikörper) gene was suppressed by theobromine. In vivo knockdown studies showed that AR1 (zeige TCF20 Antikörper) knockdown in mice attenuated the anti-adipogenic effects of theobromine in younger mice. Theobromine suppresses adipocyte differentiation and induced C/EBPbeta (zeige CEBPB Antikörper) degradation by increasing its sumoylation.
The three receptor sets considered (mAChR (zeige CHRM3 Antikörper), AR and TrkB (zeige NTRK2 Antikörper) receptors) intervene in modulating the conditions of the competition between nerve endings.
Systemic inflammatory response syndrome-associated lymphopenia is initiated by A1R desensitization and adenosine-mediated inhibition of IL-15 (zeige IL15 Antikörper) production is part of the mechanism that accounts for the delay in leukopenia recovery in patients with severe sepsis.
Results demonstrated a significant downregulation of adenosine A1 receptors in the cortex and striatum, concomitant to striatal D2R (zeige DRD2 Antikörper) downregulation in iron deficient mice and rats.
Adenosine A1A receptor and adenosine A3A receptor agonists and adenosine 5'-monophosphate cause regulated hypothermia that was characterized by a drop in total energy expenditure, physical inactivity, and preference for cooler environmental temperatures, indicating a reduced body temperature set point.
over-expression of sEH (zeige EPHX2 Antikörper) enhances A1AR-dependent contraction and reduces KATP channel-dependent relaxation in MAs (zeige MAS1 Antikörper). These results suggest a possible interaction between sEH (zeige EPHX2 Antikörper), A1AR, and KATP channels in regulating vascular tone.
Results indicate that the adenosine A1 receptor is an important molecular component mediating hypoxic depression in adult mice and it appears to stabilize respiration of neonatal mice
The findings of this study implicated a glial-neuronal circuit, mediated by Ado (zeige ADO Antikörper), neuronal AdoRA1, and glial AdK (zeige ADK Antikörper) that can modulate sleep homeostasis in a manner influenced by glial metabolic state.
Adenosine A1 receptor knockout mice displayed increased depressive-like behavior.
Data suggest that that ADORA1 forms homomers/homodimers in brain cortex.
Adenosine A1 receptors promote vasa vasorum endothelial cell barrier integrity via Gi and Akt-dependent actin cytoskeleton remodeling.
The protein encoded by this gene is an adenosine receptor that belongs to the G-protein coupled receptor 1 family. There are 3 types of adenosine receptors, each with a specific pattern of ligand binding and tissue distribution, and together they regulate a diverse set of physiologic functions. The type A1 receptors inhibit adenylyl cyclase, and play a role in the fertilization process. Animal studies also suggest a role for A1 receptors in kidney function and ethanol intoxication. Transcript variants with alternative splicing in the 5' UTR have been found for this gene.
adenosine A1 receptor
, A1 adenosine receptor
, adenosine receptor A1