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This study demonstrated a cell-autonomous requirement for ADCY8 in retinal neurons for normal midline crossing. These findings are the first to show that ADCY8 is required for axonal pathfinding before axons reach their targets.
Genetic deletion of AC8 (adenylyl cyclase 8) but not AC1 (zeige HRASLS Proteine) abolished long-lasting anxiety.
Dysregulation of a survival pathway in adenylyl cyclase 1 (zeige ADCY1 Proteine) and 8 knockout mice was identified following early-life ethanol exposure.
Study shows that AC8 is involved in epileptogenesis, and may serve as a potential target for the treatment of epilepsy
ADCY8 is required for the physiological activation of glucose-induced signalling pathways in beta cells, for glucose tolerance and for hypothalamic adaptation to a high-fat diet via regulation of islet insulin (zeige INS Proteine) secretion.
these results support a complex role of cAMP signaling pathways confirming the involvement of AC8 in the modulation of stress responses.
ACVIII gene is regulated by CREB (zeige CREB1 Proteine) in vitro and in vivo and this regulation may contribute to CREB (zeige CREB1 Proteine)-dependent neural plasticity
AC8 accumulates in puncta of dendrites and axons in hippocampal neurons and localizes with synaptic marker proteins indicating synaptic and nonsynaptic cAMP signals generated by different Ca2 (zeige CA2 Proteine)+-stimulated adenylyl cyclases are required for mossy fiber LTP (zeige SCP2 Proteine)
AC8 expression is initially restricted to the epithalamus, the hypothalamus, the superior colliculus, the cerebellar anlage the proliferative zone of the rhombic lip, and the spinal cord.
AC8 protein levels were abundant during development, with diffuse and increasing expression in the hippocampus that intensified in the CA1 (zeige CA1 Proteine)/CA2 (zeige CA2 Proteine) region by adulthood. in the presynaptic active zone and extrasynaptic fractions.
data suggest that AC1 (zeige HRASLS Proteine)/AC8 are crucial activators of cell survival signaling pathways acutely following ethanol exposure and represent molecular factors that may directly modulate the severity of symptoms associated with Fetal Alcohol Syndrome
Our results provide evidence for new loci influencing abdominal visceral (BBS9 (zeige BBS9 Proteine), ADCY8, KCNK9 (zeige KCNK9 Proteine)) and subcutaneous (MLLT10 (zeige MLLT10 Proteine)/DNAJC1 (zeige DNAJC1 Proteine)/EBLN1 (zeige EBLN2 Proteine)) fat, and confirmed a locus (THNSL2 (zeige THNSL2 Proteine)) previously reported to be associated with abdominal fat in women
Results show that promoter hypermethylation of ADCY8, CDH8 (zeige CDH8 Proteine), and ZNF582 (zeige ZNF582 Proteine) are correlated with high-grade squamous intraepithelial lesion.
ADCY8 is integral for long-term potentiation and synaptic plasticity and is implicated in fear-related learning and memory.
Polymorphisms ADCY8 are associated with an alcohol-dependent phenotype in females, which is distinguished by comorbid signs of depression.
The adenylate cyclase 8 plays a major role in cAMP production.
Orai1 and AC8 binding mediates dynamic interplay between Ca2 (zeige CA2 Proteine)+ and cAMP signaling
cAMP-mediated pathways are modelled by glucose, and downregulation of the calcium-sensitive ADCY8 plays a central role herein, including signalling via the GLP1R (zeige GLP1R Proteine).
Ca2 (zeige CA2 Proteine)+ entry increase was accompanied by red cell aggregation rise, while adenylyl cyclase-cAMP system stimulation led to red cell deformability increase and its aggregation lowered.
Data reveal that an association of the Ca(2 (zeige CA2 Proteine)+)-stimulable AC8 with AKAP79 (zeige AKAP5 Proteine)/150 that limits the sensitivity of AC8 to intracellular Ca(2 (zeige CA2 Proteine)+) events.
CaM is collapsed around the adenylyl cyclase 8 peptides that binds to CaM in an antiparallel orientation.
Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic activity is under the control of several hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase
adenylate cyclase 8 (brain)
, adenylate cyclase type VIII
, adenylate cyclase type 8
, adenylate cyclase type 8-like
, ATP pyrophosphate-lyase 8
, adenylyl cyclase 8
, ca(2+)/calmodulin-activated adenylyl cyclase
, adenylyl cyclase-8, brain
, type VIII adenylyl cyclase
, adenylate cyclase 3