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anti-Human ADCY5 Antikörper:
anti-Mouse (Murine) ADCY5 Antikörper:
anti-Rat (Rattus) ADCY5 Antikörper:
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Human Polyclonal ADCY5 Primary Antibody für WB - ABIN2801949
Wicker, Catalan, Cailleux, Starenki, Stengel, Sarasin, Suarez: Cloning and expression of human adenylyl cyclase type VI in normal thyroid tissues. in Biochimica et biophysica acta 2000
Show all 5 Pubmed References
Mouse (Murine) Polyclonal ADCY5 Primary Antibody für CM, ICC - ABIN2746164
Kolachala, Asamoah, Wang, Srinivasan, Merlin, Sitaraman: Interferon-gamma down-regulates adenosine 2b receptor-mediated signaling and short circuit current in the intestinal epithelia by inhibiting the expression of adenylate cyclase. in The Journal of biological chemistry 2005
Show all 3 Pubmed References
Human Monoclonal ADCY5 Primary Antibody für ELISA, WB - ABIN513118
Drescher, Cho, Folbe, Selvakumar, Kewson, Abu-Hamdan, Oh, Ramakrishnan, Hatfield, Khan, Anne, Harpool, Drescher: An adenylyl cyclase signaling pathway predicts direct dopaminergic input to vestibular hair cells. in Neuroscience 2010
Human Polyclonal ADCY5 Primary Antibody für ICC, IF - ABIN408294
Oh, Hwang, Lee, Choi, Kim, Kim, Sadovsky, Roh: Isolation of basal membrane proteins from BeWo cells and their expression in placentas from fetal growth-restricted pregnancies. in Placenta 2016
In this series of five ADCY5 mutation carriers, perioral twitches and truncal jerks do not represent myokymia
ADCY5-related dyskinesia may manifest variable expressivity within a single family, and affected individuals may be initially diagnosed with differing neurological phenotypes.
ADCY5 gene mutations can present with a wider variety of movement disorder syndromes.
ADCY5, which encodes adenylyl cyclase type 5, and RAP2C (zeige RAP2C Antikörper), which encodes a member of the RAS oncogene (zeige RAB1A Antikörper) family, had associations of nearly genomewide significance. ADCY5 locus have been reported to be associated with birth weight and type 2 diabetes however, none were in linkage disequilibrium with the SNPs showing significant association with gestational duration.
These data suggest that rs11708067-A risk allele contributes to type 2 diabetes by disrupting an islet enhancer, which results in reduced ADCY5 expression and impaired insulin (zeige INS Antikörper) secretion.
This study demonstrated that whole-exome sequencing show reveled ADCY5 mutation with early-onset generalized dystonia.
the clinical spectrum of ADCY5 mutations encompasses paroxysmal weakness in addition to paroxysmal dyskinesia and persistent hyperkinesia, nominating ADCY5 mutations as a genetic cause of unexplained alternating hemiplegia of childhood.
This study showed that ADCY5 mutation carriers display pleiotropic paroxysmal day and nighttime dyskinesias.(
Risk alleles for 6 loci increased glucose levels from birth to 5 years of age (ADCY5, ADRA2A (zeige ADRA2A Antikörper), CDKAL1 (zeige CDKAL1 Antikörper), CDKN2A/B, GRB10 (zeige GRB10 Antikörper), and TCF7L2 (zeige TCF7L2 Antikörper)
changes in adipose tissue ADCY5 expression are related to obesity and fat distribution.
Adenylyl cyclase 5 links changes in calcium homeostasis to cAMP-dependent cyst growth in a model of autosomal dominant polycystic liver disease.
Epac1 (zeige RAPGEF3 Antikörper) is involved in AC5-mediated catecholamine stress-induced cardiac fibrosis. Epac1 (zeige RAPGEF3 Antikörper) is involved in AC5-mediated elongation of atrial fibrillation.
In this study, we report that in the striatum AC5 exists in a stable pre-coupled complex with subunits of Golf heterotrimer.
these results suggest that AnxA4 (zeige ANXA4 Antikörper) is a novel direct negative regulator of AC5, adding a new facet to the functions of annexins.
These results identify the AC5 and mGluR system in the dorsal striatum as molecular on/off switches to direct decisions on behavioral preferences for cue-oriented options
deficiency of AC5 protects against obesity, glucose intolerance, and insulin (zeige INS Antikörper) resistance.
Myocardial adrenergic receptor beta 1 (zeige ADRB1 Antikörper) preferentially associates with AC5.
Disruption of AC5 prevents cardiomyopathy induced by chronically enhanced beta-AR signaling in mice with overexpressed beta-AR, potentially by enhancing resistance to oxidative stress and apoptosis, suggesting a novel, alternative approach to beta-AR blockade.
AC5 knockout mice delayed age-related tumor incidence significantly.
Describe developmental expression of adenylyl cyclase 5.
our data suggest that AC5 is the prevalent adenylyl cyclase isoform in rabbit renal cortex
This gene encodes a member of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein-coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded protein is stimulated by the Gs alpha subunit of G protein-coupled receptors and is inhibited by protein kinase A, calcium and Gi alpha subunits. Single nucleotide polymorphisms in this gene may be associated with low birth weight and type 2 diabetes. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene.
adenylate cyclase type 5
, adenylyl cyclase type V
, adenylate cyclase 5
, ATP pyrophosphate-lyase 5
, adenylate cyclase type V
, adenylyl cyclase 5
, ca(2+)-inhibitable adenylyl cyclase