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DNA sequencing was performed for six single-nucleotide polymorphisms in the GSTP1 (zeige GSTP1 Proteine), RAD51 (zeige RAD51 Proteine), XRCC1 (zeige XRCC1 Proteine) and XRCC3 genes in BC patients and the control group. Two variants in the 5'-UTR of the XRCC3 and RAD51 (zeige RAD51 Proteine) genes showed a significant association with susceptibility to breast cancer. Additionally, authors reported 2 mutations in intron 7 of the XRCC3 gene.
results indicate XRCC3 Thr241Met and TYMS 5'-UTR VNTR polymorphisms are associated with time-to-metastasis, and may have potential biological roles in expediting the metastatic process
hypermethylation of homologous recombination DNA repair genes including RAD51B (zeige Rad51B Proteine) and XRCC3 is associated with an inflamed phenotype in squamous cell cancers of the head and neck, lung and cervix.
Study suggested that RAD51 (zeige RAD51 Proteine), XRCC1 (zeige XRCC1 Proteine), and XRCC3 polymorphisms may be predictive factors for radiation-induced acute toxicity in rectal cancer patients treated with preoperative combined therapy.
XRCC1 Arg399Gln Gln/Gln genotype, Gln allele, and homozygote variants of XRCC3 Thr241Met polymorphism may be a risk factor for predisposition of Oral Squamous Cell Carcinoma in Turkish. In addition, XRCC3 Thr241Met genotype could be associated with tumor size and level of daily smoking.
The combined AA/AA (zeige TEAD1 Proteine) genotype and GG/GA genotype frequencies for rs1799794 and rs709399 polymorphisms were significantly higher in thyroid cancer patients compared to control group when compared with combined AA/GG genotype as reference.
the association of six non-synonymous coding variants from XRCC1 (zeige XRCC1 Proteine), XRCC3 and XPD (zeige ERCC2 Proteine) genes with hepatocellular carcinoma risk, was assessed.
The analysis results showed that the following polymorphisms were correlated with susceptibility to lung cancer: rs4646903 in CYP1A1 (zeige CYP1A1 Proteine) (P < 0.001), rs1048943 in CYP1A1 (zeige CYP1A1 Proteine) (P < 0.001), rs1695 in GSTP1 (zeige GSTP1 Proteine) (P < 0.05), rs13181 in ERCC2 (zeige ERCC2 Proteine) (P < 0.001), and rs25487 in XRCC1 (zeige XRCC1 Proteine) (P < 0.05); no such correlation existed in rs861539 in XRCC3 (P > 0.05).
based on the evidence from the large-scale case-control study and meta-analysis, the rs861539 within XRCC3 gene was associated with the risk of NPC (zeige NPC1 Proteine) under recessive model.
our study suggested that the polymorphism of rs861539 in XRCC3 was associated with increased risk of PTC (zeige F9 Proteine).
the RAD51C-XRCC3-associated Holliday junction resolvase complex associates with crossovers and may play an essential role in the resolution of recombination intermediates prior to chromosome segregation
This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified.
DNA repair protein XRCC3
, X-ray repair cross-complementing protein 3
, X-ray repair complementing defective repair in Chinese hamster cells 3
, DNA-repair protein XRCC3